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Policing Tic 'n' Toc, the doorway to chloroplasts

Policing Tic 'n' Toc, the doorway to chloroplasts
Policing Tic 'n' Toc, the doorway to chloroplasts
The organization of eukaryotic cells into different membrane-enclosed compartments requires an ordered and regulated system for targeting and translocating proteins synthesized in the cytosol across organellar membranes. Protein translocation through integral membrane proteinaceous complexes shares common principles in different organelles, whereas molecular mechanisms and energy requirements are diverse. Translocation into mitochondria and plastids requires most proteins to cross two membranes, and translocation must be regulated to accommodate environmental or metabolic changes. In the last decade, the first ideas were formulated about the regulation of protein translocation into chloroplasts, thereby laying the foundation for this field. Here, we describe recent models for the regulation of translocation by precursor protein phosphorylation, receptor dimerization, redox sensing and calcium signaling. We suggest how these mechanisms might fit within the regulatory framework for the entry of proteins into chloroplasts.
0962-8924
19-27
Oreb, Mislav
85bcf606-2b7c-4362-a88f-b99bf6cbe748
Tews, Ivo
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Schleiff, Enrico
119114bb-9cbb-45e9-a161-db45b1e9f4ba
Oreb, Mislav
85bcf606-2b7c-4362-a88f-b99bf6cbe748
Tews, Ivo
9117fc5e-d01c-4f8d-a734-5b14d3eee8dd
Schleiff, Enrico
119114bb-9cbb-45e9-a161-db45b1e9f4ba

Oreb, Mislav, Tews, Ivo and Schleiff, Enrico (2008) Policing Tic 'n' Toc, the doorway to chloroplasts. Trends in Cell Biology, 18 (1), 19-27. (doi:10.1016/j.tcb.2007.10.002). (PMID:18068366)

Record type: Article

Abstract

The organization of eukaryotic cells into different membrane-enclosed compartments requires an ordered and regulated system for targeting and translocating proteins synthesized in the cytosol across organellar membranes. Protein translocation through integral membrane proteinaceous complexes shares common principles in different organelles, whereas molecular mechanisms and energy requirements are diverse. Translocation into mitochondria and plastids requires most proteins to cross two membranes, and translocation must be regulated to accommodate environmental or metabolic changes. In the last decade, the first ideas were formulated about the regulation of protein translocation into chloroplasts, thereby laying the foundation for this field. Here, we describe recent models for the regulation of translocation by precursor protein phosphorylation, receptor dimerization, redox sensing and calcium signaling. We suggest how these mechanisms might fit within the regulatory framework for the entry of proteins into chloroplasts.

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e-pub ahead of print date: 11 January 2008
Published date: January 2008
Organisations: Centre for Biological Sciences

Identifiers

Local EPrints ID: 200555
URI: http://eprints.soton.ac.uk/id/eprint/200555
ISSN: 0962-8924
PURE UUID: a8e8ff44-92f8-4c19-aa62-80d77866b341
ORCID for Ivo Tews: ORCID iD orcid.org/0000-0002-4704-1139

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Date deposited: 26 Oct 2011 11:09
Last modified: 15 Mar 2024 03:36

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Contributors

Author: Mislav Oreb
Author: Ivo Tews ORCID iD
Author: Enrico Schleiff

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