Synthesis of heterocyclic and carbocyclic fluoro-olefins by ring-closing metathesis
Synthesis of heterocyclic and carbocyclic fluoro-olefins by ring-closing metathesis
Ring-closing metathesis (RCM) of vinyl fluoride-containing dienes in the presence of ruthenium alkylidene carbene complex 11 proceeded efficiently to give six- and seven-membered cyclic vinyl fluorides. The RCM reaction was used to prepare amine- and sulfamide-linked cyclo-olefins, as well as carbocyclic systems, from a simple commercial fluoro-olefin.
hiv protease inhibitors, dipeptide isosteres, cyclic sulfonamides, olefin metathesis, peptide isosteres, organic-synthesis, cross-metathesis, peptidomimetics, alkaloids, efficient
3403-3406
Salim, Sofia S.
d5de5263-b418-469b-b3f5-bdd05ee48387
Bellingham, Richard K.
ffa421f3-f2fb-4de9-b3f1-bba3f18b8976
Satcharoen, Vachiraporn
bd72ee7e-2c8c-4508-ba2b-0135a46859bf
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
18 September 2003
Salim, Sofia S.
d5de5263-b418-469b-b3f5-bdd05ee48387
Bellingham, Richard K.
ffa421f3-f2fb-4de9-b3f1-bba3f18b8976
Satcharoen, Vachiraporn
bd72ee7e-2c8c-4508-ba2b-0135a46859bf
Brown, Richard C.D.
21ce697a-7c3a-480e-919f-429a3d8550f5
Salim, Sofia S., Bellingham, Richard K., Satcharoen, Vachiraporn and Brown, Richard C.D.
(2003)
Synthesis of heterocyclic and carbocyclic fluoro-olefins by ring-closing metathesis.
Organic Letters, 5 (19), .
(doi:10.1021/ol035065w).
Abstract
Ring-closing metathesis (RCM) of vinyl fluoride-containing dienes in the presence of ruthenium alkylidene carbene complex 11 proceeded efficiently to give six- and seven-membered cyclic vinyl fluorides. The RCM reaction was used to prepare amine- and sulfamide-linked cyclo-olefins, as well as carbocyclic systems, from a simple commercial fluoro-olefin.
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Published date: 18 September 2003
Keywords:
hiv protease inhibitors, dipeptide isosteres, cyclic sulfonamides, olefin metathesis, peptide isosteres, organic-synthesis, cross-metathesis, peptidomimetics, alkaloids, efficient
Identifiers
Local EPrints ID: 20075
URI: http://eprints.soton.ac.uk/id/eprint/20075
ISSN: 1523-7060
PURE UUID: f788c203-7d2c-40c5-a800-80610397d80b
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Date deposited: 23 Feb 2006
Last modified: 16 Mar 2024 02:54
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Contributors
Author:
Sofia S. Salim
Author:
Richard K. Bellingham
Author:
Vachiraporn Satcharoen
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