Isolation and structure determination of an antimicrobial ester from a marine sediment-derived bacterium
Isolation and structure determination of an antimicrobial ester from a marine sediment-derived bacterium
A new compound, assigned the trivial name bonactin (1), has been isolated from the liquid culture of a Streptomyces sp. BD21-2 obtained from a shallow-water sediment sample collected at Kailua Beach, Oahu, Hawaii. Structure elucidation employed one- and two-dimensional NMR, HRFABMS, IR, and chemical analysis. Bonactin displayed antimicrobial activity against both Gram-positive and Gram-negative bacteria as well as antifungal activity.
nonactin, metabolites, acid
1291-1293
Schumacher, Robert W.
e6b8d82a-00a9-477c-a085-5798e84fe209
Talmage, Stephanie C.
c1eb786b-c6c8-4b69-ad13-c3155730a107
Miller, Sara A.
9e7a1640-bbf0-4be5-b5bd-2f240444efb8
Sarris, Katie E.
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Davidson, Bradley S.
708f2855-d8b9-467f-8401-401e2426746c
Goldberg, Arthur
351eca51-6b10-4ddc-9f97-f534be3e8774
1 September 2003
Schumacher, Robert W.
e6b8d82a-00a9-477c-a085-5798e84fe209
Talmage, Stephanie C.
c1eb786b-c6c8-4b69-ad13-c3155730a107
Miller, Sara A.
9e7a1640-bbf0-4be5-b5bd-2f240444efb8
Sarris, Katie E.
a53d4a4f-56ad-4542-9423-306d2a159028
Davidson, Bradley S.
708f2855-d8b9-467f-8401-401e2426746c
Goldberg, Arthur
351eca51-6b10-4ddc-9f97-f534be3e8774
Schumacher, Robert W., Talmage, Stephanie C., Miller, Sara A., Sarris, Katie E., Davidson, Bradley S. and Goldberg, Arthur
(2003)
Isolation and structure determination of an antimicrobial ester from a marine sediment-derived bacterium.
Journal of Natural Products, 66 (9), .
(doi:10.1021/np020594e).
Abstract
A new compound, assigned the trivial name bonactin (1), has been isolated from the liquid culture of a Streptomyces sp. BD21-2 obtained from a shallow-water sediment sample collected at Kailua Beach, Oahu, Hawaii. Structure elucidation employed one- and two-dimensional NMR, HRFABMS, IR, and chemical analysis. Bonactin displayed antimicrobial activity against both Gram-positive and Gram-negative bacteria as well as antifungal activity.
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Published date: 1 September 2003
Keywords:
nonactin, metabolites, acid
Identifiers
Local EPrints ID: 20077
URI: http://eprints.soton.ac.uk/id/eprint/20077
ISSN: 0163-3864
PURE UUID: c092e53c-580a-4bc6-851b-c57c9b67747b
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Date deposited: 24 Feb 2006
Last modified: 15 Mar 2024 06:21
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Contributors
Author:
Robert W. Schumacher
Author:
Stephanie C. Talmage
Author:
Sara A. Miller
Author:
Katie E. Sarris
Author:
Bradley S. Davidson
Author:
Arthur Goldberg
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