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The first synthesis of glucosylgalactosyl hydroxylysine (Glu-Gal-Hyl) an important biological indicator of collagen turnover

The first synthesis of glucosylgalactosyl hydroxylysine (Glu-Gal-Hyl) an important biological indicator of collagen turnover
The first synthesis of glucosylgalactosyl hydroxylysine (Glu-Gal-Hyl) an important biological indicator of collagen turnover
This paper reports the first chemical synthesis of ?-D-glucopyranosyl-(1 --> 2)-?-D-galactopyranosyl-O-hydroxylysine, a glycoside of hydroxylysine important as indicator of skin and bone collagen turnover, starting with commercial compounds.
glucosylgalactosyl hydroxylysine, collagen turnover markers, glycosylated (l)-delta-hydroxylysine.glomerular basement-membrane, solid-phase synthesis, biochemicalinterest, urinary-excretion, modular synthesis, building-block, glycosides, pyridinoline, glycopeptide, deoxypyridinoline
3319-3321
Allevi, Pietro
6d6b8007-15dc-43e8-82c0-320803057324
Anastasia, Mario
b4e4bca5-4e6d-4463-8e40-728d9d9ec2ff
Paroni, Rita
7aed7c5d-aa3d-4a5a-aa90-aad1b667b03a
Ragusa, Andrea
40dd8ad1-0a88-4d20-aa51-6949d302d363
Allevi, Pietro
6d6b8007-15dc-43e8-82c0-320803057324
Anastasia, Mario
b4e4bca5-4e6d-4463-8e40-728d9d9ec2ff
Paroni, Rita
7aed7c5d-aa3d-4a5a-aa90-aad1b667b03a
Ragusa, Andrea
40dd8ad1-0a88-4d20-aa51-6949d302d363

Allevi, Pietro, Anastasia, Mario, Paroni, Rita and Ragusa, Andrea (2004) The first synthesis of glucosylgalactosyl hydroxylysine (Glu-Gal-Hyl) an important biological indicator of collagen turnover. Bioorganic & Medicinal Chemistry Letters, 14 (12), 3319-3321. (doi:10.1016/j.bmcl.2004.03.068).

Record type: Article

Abstract

This paper reports the first chemical synthesis of ?-D-glucopyranosyl-(1 --> 2)-?-D-galactopyranosyl-O-hydroxylysine, a glycoside of hydroxylysine important as indicator of skin and bone collagen turnover, starting with commercial compounds.

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More information

Published date: 21 June 2004
Keywords: glucosylgalactosyl hydroxylysine, collagen turnover markers, glycosylated (l)-delta-hydroxylysine.glomerular basement-membrane, solid-phase synthesis, biochemicalinterest, urinary-excretion, modular synthesis, building-block, glycosides, pyridinoline, glycopeptide, deoxypyridinoline

Identifiers

Local EPrints ID: 20117
URI: https://eprints.soton.ac.uk/id/eprint/20117
PURE UUID: db28a62a-dc12-449f-8b63-7b9c17023f5e

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Date deposited: 23 Feb 2006
Last modified: 23 Oct 2018 16:30

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Contributors

Author: Pietro Allevi
Author: Mario Anastasia
Author: Rita Paroni
Author: Andrea Ragusa

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