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An analogue of adenine that forms an 'A : T' base pair of comparable stability to G : C

An analogue of adenine that forms an 'A : T' base pair of comparable stability to G : C
An analogue of adenine that forms an 'A : T' base pair of comparable stability to G : C
The heterocyclic base 7-aminopropargyl-7-deaza-2,6-diaminopurine (D) has been incorporated into oligodeoxynucleotides. D: T has similar thermodynamic stability to G:C and is a stable analogue of A:T.
dna, oligonucleotides, duplex, pyrimidines
1359-7345
2208-2209
Booth, J.
1a0f7357-ea6e-43f7-87c8-40cb97c4d070
Cummins, W. J.
01cf1d16-a2ca-4077-9081-ad7f5a94c57b
Brown, T.
a64aae36-bb30-42df-88a2-11be394e8c89
Booth, J.
1a0f7357-ea6e-43f7-87c8-40cb97c4d070
Cummins, W. J.
01cf1d16-a2ca-4077-9081-ad7f5a94c57b
Brown, T.
a64aae36-bb30-42df-88a2-11be394e8c89

Booth, J., Cummins, W. J. and Brown, T. (2004) An analogue of adenine that forms an 'A : T' base pair of comparable stability to G : C. Chemical Communications, (19), 2208-2209. (doi:10.1039/b409155h).

Record type: Article

Abstract

The heterocyclic base 7-aminopropargyl-7-deaza-2,6-diaminopurine (D) has been incorporated into oligodeoxynucleotides. D: T has similar thermodynamic stability to G:C and is a stable analogue of A:T.

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More information

Published date: 2004
Keywords: dna, oligonucleotides, duplex, pyrimidines

Identifiers

Local EPrints ID: 20142
URI: http://eprints.soton.ac.uk/id/eprint/20142
ISSN: 1359-7345
PURE UUID: aa2c983e-c4eb-4bb6-a3ac-2bac6f81ba4f

Catalogue record

Date deposited: 22 Feb 2006
Last modified: 15 Mar 2024 06:22

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Contributors

Author: J. Booth
Author: W. J. Cummins
Author: T. Brown

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