Clarke, P., Jeffery, M. J., Boydell, A. J., Whiting, S. and Linclau, B.
Full and partial differentiation of tris-1,1,1-(hydroxymethyl)ethane via direct and indirect methodology
Tetrahedron, 60, (16), . (doi:10.1016/j.tet.2004.02.056).
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Tris-1,1,1-(hydroxymethyl)ethane 1 was converted to a series of mono- and disubstituted derivatives. An indirect protocol for the differentiation of the alcohol groups was employed for the synthesis of partially and fully differentiated 1 containing a protected aldehyde unit. Complete differentiation of the alcohol groups was also achieved using a direct strategy (two steps from 1). The first synthesis of 1,3-dialclehydes derived from 1 is reported in two steps.
|Digital Object Identifier (DOI):
||scaffold, building block, alcohol differentiation, chemoselective
acetal cleavageo-iodoxybenzoic acid, ring-closing metathesis, surfacefunctionalization, pentaerythritol, oxidation, alcohols, diols, derivatives, 1, 4-diols, reduction
|12 April 2004||Published|
||17 Feb 2006
||16 Apr 2017 22:59
|Further Information:||Google Scholar|
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