The University of Southampton
University of Southampton Institutional Repository

Lung cancer mortality in a cohort of UK cotton workers: an extended follow-up

Lung cancer mortality in a cohort of UK cotton workers: an extended follow-up
Lung cancer mortality in a cohort of UK cotton workers: an extended follow-up
Background: a recent systematic review and meta-analysis suggested that occupational exposure to endotoxins protects against lung cancer. To explore this hypothesis further, the follow-up of mortality of a cohort of 3551 workers, who were employed in the British cotton industry during 1966–1971, was extended by 23 years.

Methods: subjects had originally been recruited to a survey of respiratory disease, which collected information about occupation and smoking habits. Cumulative exposures to endotoxins were estimated from data on endotoxin levels by work areas in cotton mills. Risks of lung cancer were estimated using survival modelling.

Results: during follow-up, 2018 deaths were recorded before the age of 90 years, including 128 deaths from lung cancer. After adjustment for smoking, hazard ratios (95% confidence intervals) for cumulative endotoxin exposures of less than or equal to30?000, >30?000 and less than or equal to200?000, >200?000 and less than or equal to400?000, >400?000 and less than or equal to600?000 and >600?000 endotoxin units (EU)?m?3 years were 1, 0.8 (0.5–1.6), 0.7 (0.4–1.3), 0.6 (0.3–1.0) and 0.5 (0.3–0.9), respectively (P for trend=0.005).

Conclusion: our findings strengthen the evidence that occupational exposure to endotoxins protects against lung cancer, and suggest that the effect depends on cumulative dose and persists after exposure ceases
0007-0920
1054-1060
McElvenny, D.M.
7420613d-2ed0-44a7-bf2d-1f3bc037ce14
Hurley, M.A.
411e34d5-ac64-4670-b1fb-fceae7dece09
Lenters, V.
ec742ef5-8ffb-4e58-9c60-75657946e53f
Heederik, D.
60d5b77f-5612-40a3-992e-e5d116afab36
Wilkinson, S.
515fffa9-1b52-4208-9898-563773dda70a
Coggon, D.
2b43ce0a-cc61-4d86-b15d-794208ffa5d3
McElvenny, D.M.
7420613d-2ed0-44a7-bf2d-1f3bc037ce14
Hurley, M.A.
411e34d5-ac64-4670-b1fb-fceae7dece09
Lenters, V.
ec742ef5-8ffb-4e58-9c60-75657946e53f
Heederik, D.
60d5b77f-5612-40a3-992e-e5d116afab36
Wilkinson, S.
515fffa9-1b52-4208-9898-563773dda70a
Coggon, D.
2b43ce0a-cc61-4d86-b15d-794208ffa5d3

McElvenny, D.M., Hurley, M.A., Lenters, V., Heederik, D., Wilkinson, S. and Coggon, D. (2011) Lung cancer mortality in a cohort of UK cotton workers: an extended follow-up. British Journal of Cancer, 105, 1054-1060. (doi:10.1038/bjc.2011.312). (PMID:21847124)

Record type: Article

Abstract

Background: a recent systematic review and meta-analysis suggested that occupational exposure to endotoxins protects against lung cancer. To explore this hypothesis further, the follow-up of mortality of a cohort of 3551 workers, who were employed in the British cotton industry during 1966–1971, was extended by 23 years.

Methods: subjects had originally been recruited to a survey of respiratory disease, which collected information about occupation and smoking habits. Cumulative exposures to endotoxins were estimated from data on endotoxin levels by work areas in cotton mills. Risks of lung cancer were estimated using survival modelling.

Results: during follow-up, 2018 deaths were recorded before the age of 90 years, including 128 deaths from lung cancer. After adjustment for smoking, hazard ratios (95% confidence intervals) for cumulative endotoxin exposures of less than or equal to30?000, >30?000 and less than or equal to200?000, >200?000 and less than or equal to400?000, >400?000 and less than or equal to600?000 and >600?000 endotoxin units (EU)?m?3 years were 1, 0.8 (0.5–1.6), 0.7 (0.4–1.3), 0.6 (0.3–1.0) and 0.5 (0.3–0.9), respectively (P for trend=0.005).

Conclusion: our findings strengthen the evidence that occupational exposure to endotoxins protects against lung cancer, and suggest that the effect depends on cumulative dose and persists after exposure ceases

Full text not available from this repository.

More information

Published date: 16 August 2011
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 201959
URI: http://eprints.soton.ac.uk/id/eprint/201959
ISSN: 0007-0920
PURE UUID: fb235acd-c4eb-4dd5-a3ee-4712e8bcb52a
ORCID for D. Coggon: ORCID iD orcid.org/0000-0003-1930-3987

Catalogue record

Date deposited: 03 Nov 2011 11:54
Last modified: 20 Jul 2019 01:16

Export record

Altmetrics

Contributors

Author: D.M. McElvenny
Author: M.A. Hurley
Author: V. Lenters
Author: D. Heederik
Author: S. Wilkinson
Author: D. Coggon ORCID iD

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×