The University of Southampton
University of Southampton Institutional Repository

Shift work and pregnancy outcomes: a systematic review with meta-analysis of currently available epidemiological studies

Bonzini, M., Palmer, K., Coggon, D., Cromi, A. and Ferrario, M. (2011) Shift work and pregnancy outcomes: a systematic review with meta-analysis of currently available epidemiological studies BJOG: An International Journal of Obstetrics & Gynaecology, 118, (12), pp. 1429-1437. (doi:10.1111/j.1471-0528.2011.03066.x). (PMID:21790955).

Record type: Article


Background: varying work schedules are suspected of increasing risks to pregnant women and to fetal wellbeing. In particular, maternal hormonal disturbance arising from sleep deprivation or circadian rhythm disruption might impair fetal growth or lead to complications of pregnancy. Two independent meta-analyses (from 2000 to 2007) reported a small adverse effect of shift work on the risk of preterm delivery (PTD). However, these reviews were based on few high-quality studies.

Objectives: to provide an updated review of the associations of shift work with PTD, low birthweight (LBW), small-for-gestational-age (SGA) infants and pre-eclampsia.

Search strategy and selection criteria: we conducted a systematic search of MEDLINE using combinations of keywords and MeSH terms.

Data collection and analysis: for each relevant paper we abstracted standard details, used to summarise design features and rate methodological quality. We calculated pooled estimates of relative risk (RR) in random-effect meta-analyses.

Main results: we retrieved 23 relevant studies. The pooled estimate of RR for PTD was 1.16 (95% CI 1.00–1.33, 16 studies), but when five reports of poorer methodological quality were excluded, the estimated RR decreased to 1.03 (95% CI 0.93–1.14). We also observed increased RRs for LBW (RR 1.27, 95% CI 0.93–1.74) and for SGA (RR 1.12, 95% CI 1.03–1.22), which varied little by study quality. Little evidence was found on pre-eclampsia.

Conclusions: these findings suggest that overall, any risk of PTD, LBW, or SGA arising from shift work in pregnancy is small

Full text not available from this repository.

More information

e-pub ahead of print date: 27 July 2011
Published date: November 2011
Organisations: Faculty of Medicine


Local EPrints ID: 201977
ISSN: 1470-0328
PURE UUID: b59c7557-30d9-4247-b6bc-eafe2403d21c
ORCID for D. Coggon: ORCID iD

Catalogue record

Date deposited: 03 Nov 2011 11:09
Last modified: 12 Oct 2017 16:32

Export record



Author: M. Bonzini
Author: K. Palmer
Author: D. Coggon ORCID iD
Author: A. Cromi
Author: M. Ferrario

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.