Invariant natural killer T cells recognise lipid self antigen induced by microbial danger signals
Invariant natural killer T cells recognise lipid self antigen induced by microbial danger signals
Invariant natural killer T cells (iNKT cells) have a prominent role during infection and other inflammatory processes, and these cells can be activated through their T cell antigen receptors by microbial lipid antigens. However, increasing evidence shows that they are also activated in situations in which foreign lipid antigens would not be present, which suggests a role for lipid self antigen. We found that an abundant endogenous lipid, ?-D-glucopyranosylceramide (?-GlcCer), was a potent iNKT cell self antigen in mouse and human and that its activity depended on the composition of the N-acyl chain. Furthermore, ?-GlcCer accumulated during infection and in response to Toll-like receptor agonists, contributing to iNKT cell activation. Thus, we propose that recognition of ?-GlcCer by the invariant T cell antigen receptor translates innate danger signals into iNKT cell activation
Brennan, Patrick J.
a8f4fcc0-39ce-4827-b4e6-be5b3e372e26
Tatituri, Raju V.V.
c821e237-49b7-40a0-a576-19d33c60cb83
Brigl, Manfred
e708e1fc-35dd-41c8-a2c6-e13583ea4493
Kim, Edy Y.
f57eabf2-a422-4be5-936e-bf224cebf11e
Tuli, Aamit
9ff546f5-41cf-47af-8038-1d16fb16bb87
Sanderson, Joseph P.
55f9cdfc-ab1e-4b84-8c02-83c4d51cfcfe
Gadola, Stephan D.
ef2fa6cf-2ccc-4fea-a7a5-cc03a9d13ab1
Hsu, Fong-Fu
d6827f7d-06c3-45b3-810b-5c859d0fa0e6
Besra, Gurdyal S.
b3523122-c452-4efc-b625-d80744586a47
Brenner, Michael B.
ec8181bd-a1b3-4f00-b2fb-8a7799a80797
Brennan, Patrick J.
a8f4fcc0-39ce-4827-b4e6-be5b3e372e26
Tatituri, Raju V.V.
c821e237-49b7-40a0-a576-19d33c60cb83
Brigl, Manfred
e708e1fc-35dd-41c8-a2c6-e13583ea4493
Kim, Edy Y.
f57eabf2-a422-4be5-936e-bf224cebf11e
Tuli, Aamit
9ff546f5-41cf-47af-8038-1d16fb16bb87
Sanderson, Joseph P.
55f9cdfc-ab1e-4b84-8c02-83c4d51cfcfe
Gadola, Stephan D.
ef2fa6cf-2ccc-4fea-a7a5-cc03a9d13ab1
Hsu, Fong-Fu
d6827f7d-06c3-45b3-810b-5c859d0fa0e6
Besra, Gurdyal S.
b3523122-c452-4efc-b625-d80744586a47
Brenner, Michael B.
ec8181bd-a1b3-4f00-b2fb-8a7799a80797
Brennan, Patrick J., Tatituri, Raju V.V., Brigl, Manfred, Kim, Edy Y., Tuli, Aamit, Sanderson, Joseph P., Gadola, Stephan D., Hsu, Fong-Fu, Besra, Gurdyal S. and Brenner, Michael B.
(2011)
Invariant natural killer T cells recognise lipid self antigen induced by microbial danger signals.
Nature Immunology.
(doi:10.1038/ni.2143).
(PMID:22037601)
Abstract
Invariant natural killer T cells (iNKT cells) have a prominent role during infection and other inflammatory processes, and these cells can be activated through their T cell antigen receptors by microbial lipid antigens. However, increasing evidence shows that they are also activated in situations in which foreign lipid antigens would not be present, which suggests a role for lipid self antigen. We found that an abundant endogenous lipid, ?-D-glucopyranosylceramide (?-GlcCer), was a potent iNKT cell self antigen in mouse and human and that its activity depended on the composition of the N-acyl chain. Furthermore, ?-GlcCer accumulated during infection and in response to Toll-like receptor agonists, contributing to iNKT cell activation. Thus, we propose that recognition of ?-GlcCer by the invariant T cell antigen receptor translates innate danger signals into iNKT cell activation
This record has no associated files available for download.
More information
e-pub ahead of print date: 30 October 2011
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 202079
URI: http://eprints.soton.ac.uk/id/eprint/202079
ISSN: 1529-2908
PURE UUID: cc6db02d-3509-49d9-99e0-5701e3a99c74
Catalogue record
Date deposited: 03 Nov 2011 12:12
Last modified: 14 Mar 2024 04:23
Export record
Altmetrics
Contributors
Author:
Patrick J. Brennan
Author:
Raju V.V. Tatituri
Author:
Manfred Brigl
Author:
Edy Y. Kim
Author:
Aamit Tuli
Author:
Joseph P. Sanderson
Author:
Stephan D. Gadola
Author:
Fong-Fu Hsu
Author:
Gurdyal S. Besra
Author:
Michael B. Brenner
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics