The University of Southampton
×
Filter your search:
University of Southampton Institutional Repository

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10?8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
1061-4036
1082-1090
Artigas, María Soler
94c8730d-36f4-4266-885f-9335845fe558
Loth, Daan W
9de42ce0-e808-47b9-901a-e170781d466e
Wain, Louise V
3fa0e39c-3251-4095-b99d-5bc224dbb7ae
Gharib, Sina A
7ac54181-0115-40b0-960f-531ecf3d3b6d
Obeidat, Ma'en
788c5b1d-c7ee-459e-a473-85f71886459b
Tang, Wenbo
6ca86272-275d-4d01-b22d-71fbe3e1f73e
Zhai, Guangju
9108920e-4990-4b43-908f-cf0bbe1be909
Zhao, Jing Hua
b79522c0-ea16-4dd1-8405-cec85df7b9f5
Smith, Albert Vernon
9de4732a-0fea-4316-a26c-a982c0dac4d5
Huffman, Jennifer E
bc75aa9c-bcb0-4df2-abb4-38087dd0739f
Albrecht, Eva
13328998-37ee-45cc-9f50-f56eed14dd9e
Jackson, Catherine M
94d63ce4-f7b5-460f-844b-5593bb5d861f
Evans, David M
5fb407f1-4079-4017-9bbd-aea529a3cecf
Cadby, Gemma
0dc7dc13-65aa-45e6-b7c4-66ebb76ee714
Fornage, Myriam
025db3a3-a618-4b8b-9dee-0c4121fe6d66
Manichaikul, Ani
f255e5df-8e30-41d9-945b-5a407cc06dc8
Lopez, Lorna M
81c26c37-b907-497b-a6db-1993079dc679
Johnson, Toby
bfc52812-3179-4a21-ba30-6353dcc122c2
Aldrich, Melinda C
b176ec59-b3ef-4e69-a0dd-80522c82b189
Aspelund, Thor
86666aea-6141-4c5f-acad-6b0feda548f6
Barroso, Inês
ac2334b6-1e7d-40a7-a4af-7697e210db6e
Campbell, Harry
7ef78bec-0f39-477c-baa5-a773d59aa7c7
Cassano, Patricia A
6cc7c001-edb5-4228-bbfd-d44147ae56f2
Couper, David J
9ec7e018-a9b7-4d67-ace4-4d36983e703e
Eiriksdottir, Gudny
96b3f034-ed58-4731-95a1-aed7e62a054d
Franceschini, Nora
ac6ef51a-a750-46f0-a6f0-bedc2d118798
Garcia, Melissa
2a05f345-3500-4170-b36b-d4b6bd7a0afd
Gieger, Christian
45f48b74-8ab8-4be6-ad54-91e61163ed5e
Gislason, Gauti Kjartan
2569291d-04d5-4fb1-95fe-24859c91116f
Grkovic, Ivica
70a93ea5-eddc-406f-8b24-2e69e54e6b88
Hammond, Christopher J
a0ca3e05-61b7-41c4-bfed-b589aab06308
Hancock, Dana B
834198c2-a52a-483c-8880-6bf298b65822
Harris, Tamara B
6dd26b7b-e47b-4bea-84fc-2ece7d998687
Ramasamy, Adaikalavan
3b377e78-09c4-451f-8010-e1b9b7414739
Heckbert, Susan R
52e4b0b5-30b0-4db6-b14e-040202e032da
Heliövaara, Markku
d50d2747-66a8-4c75-82a7-2c019c692b91
Homuth, Georg
932c3501-8ff1-4c53-b329-41e658a68e8b
Hysi, Pirro G
aa3844c8-e5ac-4ebd-ad1c-56bc9c227a3d
James, Alan L
711255c3-1f94-406d-9cb8-57f0e11de8da
Jankovic, Stipan
921e28ea-c48c-42d1-b592-9a413da31eaf
Joubert, Bonnie R
b1a69811-1490-4fed-9eeb-42f25db605f2
Karrasch, Stefan
115d9043-e6e7-476e-a241-a6253f8a2041
Klopp, Norman
cf541817-fd4c-4d14-a495-47ead7514da2
Koch, Beate
4ae28683-a179-43bb-badf-d0e74d286290
Kritchevsky, Stephen B
ee1dd7ea-6a1e-42de-a0ce-9c1263d6c1e5
Launer, Lenore J
ec96a484-c5d4-4c5e-8375-429d243a61cd
Liu, Yongmei
26d47909-5812-45a8-8014-8b94ce8ccb85
Loehr, Laura R
fad05ccf-8801-47da-8aac-e2dee9fc50c8
Lohman, Kurt
fc134d91-4b9c-4865-8198-c1926842b571
Loos, Ruth J F
abd280f6-306c-4138-85b7-7b80a0ae0a4a
Lumley, Thomas
fe8fb9b6-88e1-4895-a764-a29f86242c3b
Al Balushi, Khalid A
d54f9530-84e1-4584-8dde-69df65d01e84
Ang, Wei Q
e5f1ac0b-5b15-4677-8c8f-8dff6125c58a
Barr, R Graham
c29dec2b-c3b4-4bf9-9613-f57c71def206
Beilby, John
4d0d71b7-a8bc-461c-8432-7715a6251615
Blakey, John D
56ba3673-4fb8-43ca-989f-5d13ed0c09b5
Boban, Mladen
a547f1a3-220a-4275-9598-f9a209102b42
Boraska, Vesna
d02553e4-3d6b-44c0-b8cb-acd80e923a20
Brisman, Jonas
11c9fa67-e48c-49f1-be88-4a885142c6a7
Britton, John R
80dc7dda-6a2c-40d5-9b8c-f9e9c43a71e2
Brusselle, Guy G
2672a271-6c30-4841-ac84-10340bcf0bc8
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Curjuric, Ivan
ef711016-ce10-44eb-8403-70392cb67f74
Dahgam, Santosh
5bc7f91f-d76a-4037-92af-bc19981083ce
Deary, Ian J
67e427d0-1022-41f8-807f-4a8dac6e01f8
Ebrahim, Shah
0f2ade5c-4ef6-4ca7-9f9b-9b60ba192b13
Eijgelsheim, Mark
65c93cd6-3b6e-4172-8750-9ee12a1586b9
Francks, Clyde
69a25afb-eb75-416d-9d97-f1c268a76500
Gaysina, Darya
d6891bea-29d3-4ffb-812f-19b1c6a139d7
Granell, Raquel
06e9e006-3754-4cc9-b3fc-42024bd05123
Gu, Xiangjun
abdcb7a6-a063-4316-a283-80ff114d2540
Hankinson, John L
9fb0630e-e3bd-4bd3-863a-cd1b97fbb53d
Hardy, Rebecca
99fecbaf-fc92-4354-aa02-cb904dd2bd32
Harris, Sarah E
35032c83-4f4f-43ca-b0f0-783562f2c272
Henderson, John
dcb5516b-cca2-49b5-8a17-f4cf707daa36
Henry, Amanda
b1247292-74a7-45f9-b4d3-7023ee9e55a2
Hingorani, Aroon D
9a25a6b9-43f0-457d-91c6-cca5372573ec
Hofman, Albert
19e6a48f-bef9-43bd-8c54-1b6057ead0bc
Holt, Patrick G
e1b8fc2d-2c79-4674-a6bf-f4b047e6164f
Hui, Jennie
2061cfdb-e779-4b63-ad8d-6c91d5f6c119
Hunter, Michael L
debb17fa-e00a-47fe-b752-d2d126ad4256
Imboden, Medea
7ac4495d-e803-4e18-b6ba-318da568f776
Jameson, Karen A
d5fb142d-06af-456e-9016-17497f94e9f2
Kerr, Shona M
627b1858-a1d1-4cbd-921b-8501ab39d4f3
Kolcic, Ivana
9689f967-2fbf-4c09-8e36-595c51a77275
Kronenberg, Florian
056e8fa9-c2f1-4d61-a849-19ad35ed5c34
Liu, Jason Z
4bda783a-84d2-4b32-9af6-9ce30c93fce7
Marchini, Jonathan
e98649d0-f4b6-4295-80e2-2eee6a97fc4e
McKeever, Tricia
b06bca95-4829-409f-8331-44d424f9c4b3
Morris, Andrew D
d6c7253e-8ab1-4394-a115-280d60e39845
Olin, Anna-Carin
2613f8f9-ce9e-4fec-b66d-8b84fb82e417
Porteous, David J
7c036c8c-866c-42e6-87b6-5412dd120de7
Postma, Dirkje S
cb6cd9ac-50b8-451d-b46f-7d7736946eed
Rich, Stephen S
9ab027e0-bda0-4947-9659-d5269337a469
Ring, Susan M
44a6327f-35c5-40d6-b0aa-11e4413b7f10
Rivadeneira, Fernando
8441b9d3-6d8e-4b33-8827-dd70d80db200
Rochat, Thierry
acba6b3d-a224-41e6-be94-f204e2d16f94
Sayer, Avan Aihie
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Sayers, Ian
8595fc2e-102b-406c-ba26-269b8bdba786
Sly, Peter D
2e6acc16-8e7c-46fe-bba4-025ea0463f14
Smith, George Davey
f5bc8327-f2cb-49a0-8eae-4a6ba63207a2
Sood, Akshay
e6882905-7d01-4dc2-8571-2b7eaa649cbe
Starr, John M
7f9cb247-6a31-452e-9cfb-910a1b731a23
Uitterlinden, André G
3602fdd2-b484-4be5-91e6-403a281a43f7
Vonk, Judith M
8a2cadb9-0c50-4976-a718-6ccaa83a6b82
Wannamethee, S Goya
acedbe38-4ff8-4ebc-9ce7-e9737c4056d0
Whincup, Peter H
5aedc15b-5cfe-4e3a-8880-828da1b3abaf
Wijmenga, Cisca
3acbef11-8ba0-4cc8-bf0d-4046aece2e7d
Williams, O Dale
fb7db5cc-3eca-459c-b4d5-096ac8ac22aa
Wong, Andrew
64a5fd30-a16e-4fba-a4d9-8d3fffeaa8f9
Mangino, Massimo
19ad1660-3639-45a8-93d6-e6a9b5c1c64b
Marciante, Kristin D
e733ac6b-4c19-46b9-98c7-41127f0d5538
McArdle, Wendy L
60abb308-b0cb-45aa-8492-72ed9b3539b7
Meibohm, Bernd
aab34cee-df67-48a3-b1aa-e586116d7fa1
Morrison, Alanna C
6667cb2b-610f-4eb1-9e33-9cd21a731a34
North, Kari E
aa9af560-25a2-49ac-97d8-d1a6bada8412
Omenaas, Ernst
7ad62321-7087-4201-9f63-0d17d3f7d14a
Palmer, Lyle J
4004a1f8-01fa-4cb0-a846-7fb7b422a5a3
Pietiläinen, Kirsi H
c7091d90-95a7-4f95-98c5-c6532b558b39
Pin, Isabelle
73224fd9-fb5a-4792-8f21-ed0de15adaa1
Pola Sbreve Ek, Ozren
9aad1f60-384e-4ebe-ab30-da0e0045ad3b
Pouta, Anneli
108c5aa1-3b41-4095-91fa-ecd523934370
Psaty, Bruce M
f7ebcc9e-8b54-4704-8711-c658540b5cd2
Hartikainen, Anna-Liisa
f3af50ad-2846-4220-9cf8-9c535b9dd908
Rantanen, Taina
db75d4bf-e534-4909-8895-6777a9e2061f
Ripatti, Samuli
705fa391-c779-4941-814c-8ce1f8fbefb7
Rotter, Jerome I
2efb96a5-f0ce-4428-9ac8-fb762561c755
Rudan, Igor
89b94981-36be-463c-9068-fd2140b05903
Rudnicka, Alicja R
891dca88-1fd4-41ff-80bb-0d26f0fa9b36
Schulz, Holger
05d1d455-f27e-4e52-919f-08963742aabf
Shin, So-Youn
17f85485-0b29-42c3-b690-4817375be839
Spector, Tim D
965dbeb9-fc69-4283-b1a3-3aa1fcd38e96
Surakka, Ida
99141cb0-65ed-44eb-9ac0-ee5e30cc57bc
Vitart, Veronique
30073df8-6255-430e-a143-d600fa48bacd
Völzke, Henry
7a82b5da-95dd-4f33-9e7f-693e50ff19cb
Wareham, Nicholas J
e62762ff-10eb-4f15-b96a-c6b4f222f4e2
Warrington, Nicole M
b8baf55f-1bd8-45ae-ab97-cb2d582923ee
Wichmann, H-Erich
4628c10c-ff92-4eae-9ee8-7122efa70425
Wild, Sarah H
3b9da54e-590d-42b2-89a1-5ee51c2a13d8
Wilk, Jemma B
ed750c55-f012-45f2-8cc9-a3d44df66b9b
Wjst, Matthias
bb5da074-3243-4e82-a36b-197a4df5a2b8
Wright, Alan F
60e517d0-7e85-4e69-bdeb-926339a300dc
Zgaga, Lina
7b45db7b-b6d5-48b2-972a-f86325b209df
Zemunik, Tatijana
3d6027a5-5b90-41e5-9420-76593e4b1a4c
Pennell, Craig E
a17aa59a-ee38-4b50-943f-245755e5460c
Nyberg, Fredrik
6e5ecce8-308c-4854-b291-64ce8ebfd644
Kuh, Diana
4f3b51aa-21a0-4d68-be14-e1ed75448aaf
Holloway, John W
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Boezen, H Marike
934ce213-78b3-4472-8c66-b233a6374ccf
Lawlor, Debbie A
220a802a-1560-4433-b4fa-fadbc336b1f4
Morris, Richard W
cba363b1-3668-4159-89d1-25eac95a0ab0
Probst-Hensch, Nicole
33ee3cca-a1d4-4157-87c3-20ebfd84406f
Kaprio, Jaakko
de018b67-5b73-4c34-94af-8fbc4a4ff34d
Wilson, James F
a4770d88-8ec4-499f-8600-0539e35ea43c
Hayward, Caroline
8b58ae74-401a-4306-8b8f-c8414485131c
Kähönen, Mika
1155e797-98f0-4204-96be-b8f410155340
Heinrich, Joachim
bd0a5948-41cb-4541-87ad-1b86e51f6d2a
Musk, Arthur W
2367174a-fedc-46c4-bd4c-8c24eb48fb9c
Jarvis, Deborah L
9e8ece92-3265-42e4-9240-2beccacb00cd
Gläser, Sven
b5f08459-91cf-448b-ab80-46622a4c3988
Järvelin, Marjo-Riitta
eb1fa1c9-add7-4f22-b314-1548d28a286b
Ch Stricker, Bruno H
f0420356-d9d5-44bd-ad54-6362ce3c6161
Elliott, Paul
5e19ee8c-f18a-417e-ad53-bc807fdfd191
O'Connor, George T
330168be-4b3d-4948-be8a-3bd4273ed22f
Strachan, David P
8bd6230e-1a7b-4a85-bd5e-e13e08f760b2
London, Stephanie J
320afdd8-d870-49a0-9f68-b409fb522e85
Hall, Ian P
a58b8b48-5b81-41e1-9172-d490b1fe58a4
Gudnason, Vilmundur
75cefe2e-c5f6-4d85-9a92-cd8c29dd6a94
Tobin, Martin D
b732834c-d937-4f6a-a2eb-2669c118b167
Artigas, María Soler
94c8730d-36f4-4266-885f-9335845fe558
Loth, Daan W
9de42ce0-e808-47b9-901a-e170781d466e
Wain, Louise V
3fa0e39c-3251-4095-b99d-5bc224dbb7ae
Gharib, Sina A
7ac54181-0115-40b0-960f-531ecf3d3b6d
Obeidat, Ma'en
788c5b1d-c7ee-459e-a473-85f71886459b
Tang, Wenbo
6ca86272-275d-4d01-b22d-71fbe3e1f73e
Zhai, Guangju
9108920e-4990-4b43-908f-cf0bbe1be909
Zhao, Jing Hua
b79522c0-ea16-4dd1-8405-cec85df7b9f5
Smith, Albert Vernon
9de4732a-0fea-4316-a26c-a982c0dac4d5
Huffman, Jennifer E
bc75aa9c-bcb0-4df2-abb4-38087dd0739f
Albrecht, Eva
13328998-37ee-45cc-9f50-f56eed14dd9e
Jackson, Catherine M
94d63ce4-f7b5-460f-844b-5593bb5d861f
Evans, David M
5fb407f1-4079-4017-9bbd-aea529a3cecf
Cadby, Gemma
0dc7dc13-65aa-45e6-b7c4-66ebb76ee714
Fornage, Myriam
025db3a3-a618-4b8b-9dee-0c4121fe6d66
Manichaikul, Ani
f255e5df-8e30-41d9-945b-5a407cc06dc8
Lopez, Lorna M
81c26c37-b907-497b-a6db-1993079dc679
Johnson, Toby
bfc52812-3179-4a21-ba30-6353dcc122c2
Aldrich, Melinda C
b176ec59-b3ef-4e69-a0dd-80522c82b189
Aspelund, Thor
86666aea-6141-4c5f-acad-6b0feda548f6
Barroso, Inês
ac2334b6-1e7d-40a7-a4af-7697e210db6e
Campbell, Harry
7ef78bec-0f39-477c-baa5-a773d59aa7c7
Cassano, Patricia A
6cc7c001-edb5-4228-bbfd-d44147ae56f2
Couper, David J
9ec7e018-a9b7-4d67-ace4-4d36983e703e
Eiriksdottir, Gudny
96b3f034-ed58-4731-95a1-aed7e62a054d
Franceschini, Nora
ac6ef51a-a750-46f0-a6f0-bedc2d118798
Garcia, Melissa
2a05f345-3500-4170-b36b-d4b6bd7a0afd
Gieger, Christian
45f48b74-8ab8-4be6-ad54-91e61163ed5e
Gislason, Gauti Kjartan
2569291d-04d5-4fb1-95fe-24859c91116f
Grkovic, Ivica
70a93ea5-eddc-406f-8b24-2e69e54e6b88
Hammond, Christopher J
a0ca3e05-61b7-41c4-bfed-b589aab06308
Hancock, Dana B
834198c2-a52a-483c-8880-6bf298b65822
Harris, Tamara B
6dd26b7b-e47b-4bea-84fc-2ece7d998687
Ramasamy, Adaikalavan
3b377e78-09c4-451f-8010-e1b9b7414739
Heckbert, Susan R
52e4b0b5-30b0-4db6-b14e-040202e032da
Heliövaara, Markku
d50d2747-66a8-4c75-82a7-2c019c692b91
Homuth, Georg
932c3501-8ff1-4c53-b329-41e658a68e8b
Hysi, Pirro G
aa3844c8-e5ac-4ebd-ad1c-56bc9c227a3d
James, Alan L
711255c3-1f94-406d-9cb8-57f0e11de8da
Jankovic, Stipan
921e28ea-c48c-42d1-b592-9a413da31eaf
Joubert, Bonnie R
b1a69811-1490-4fed-9eeb-42f25db605f2
Karrasch, Stefan
115d9043-e6e7-476e-a241-a6253f8a2041
Klopp, Norman
cf541817-fd4c-4d14-a495-47ead7514da2
Koch, Beate
4ae28683-a179-43bb-badf-d0e74d286290
Kritchevsky, Stephen B
ee1dd7ea-6a1e-42de-a0ce-9c1263d6c1e5
Launer, Lenore J
ec96a484-c5d4-4c5e-8375-429d243a61cd
Liu, Yongmei
26d47909-5812-45a8-8014-8b94ce8ccb85
Loehr, Laura R
fad05ccf-8801-47da-8aac-e2dee9fc50c8
Lohman, Kurt
fc134d91-4b9c-4865-8198-c1926842b571
Loos, Ruth J F
abd280f6-306c-4138-85b7-7b80a0ae0a4a
Lumley, Thomas
fe8fb9b6-88e1-4895-a764-a29f86242c3b
Al Balushi, Khalid A
d54f9530-84e1-4584-8dde-69df65d01e84
Ang, Wei Q
e5f1ac0b-5b15-4677-8c8f-8dff6125c58a
Barr, R Graham
c29dec2b-c3b4-4bf9-9613-f57c71def206
Beilby, John
4d0d71b7-a8bc-461c-8432-7715a6251615
Blakey, John D
56ba3673-4fb8-43ca-989f-5d13ed0c09b5
Boban, Mladen
a547f1a3-220a-4275-9598-f9a209102b42
Boraska, Vesna
d02553e4-3d6b-44c0-b8cb-acd80e923a20
Brisman, Jonas
11c9fa67-e48c-49f1-be88-4a885142c6a7
Britton, John R
80dc7dda-6a2c-40d5-9b8c-f9e9c43a71e2
Brusselle, Guy G
2672a271-6c30-4841-ac84-10340bcf0bc8
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Curjuric, Ivan
ef711016-ce10-44eb-8403-70392cb67f74
Dahgam, Santosh
5bc7f91f-d76a-4037-92af-bc19981083ce
Deary, Ian J
67e427d0-1022-41f8-807f-4a8dac6e01f8
Ebrahim, Shah
0f2ade5c-4ef6-4ca7-9f9b-9b60ba192b13
Eijgelsheim, Mark
65c93cd6-3b6e-4172-8750-9ee12a1586b9
Francks, Clyde
69a25afb-eb75-416d-9d97-f1c268a76500
Gaysina, Darya
d6891bea-29d3-4ffb-812f-19b1c6a139d7
Granell, Raquel
06e9e006-3754-4cc9-b3fc-42024bd05123
Gu, Xiangjun
abdcb7a6-a063-4316-a283-80ff114d2540
Hankinson, John L
9fb0630e-e3bd-4bd3-863a-cd1b97fbb53d
Hardy, Rebecca
99fecbaf-fc92-4354-aa02-cb904dd2bd32
Harris, Sarah E
35032c83-4f4f-43ca-b0f0-783562f2c272
Henderson, John
dcb5516b-cca2-49b5-8a17-f4cf707daa36
Henry, Amanda
b1247292-74a7-45f9-b4d3-7023ee9e55a2
Hingorani, Aroon D
9a25a6b9-43f0-457d-91c6-cca5372573ec
Hofman, Albert
19e6a48f-bef9-43bd-8c54-1b6057ead0bc
Holt, Patrick G
e1b8fc2d-2c79-4674-a6bf-f4b047e6164f
Hui, Jennie
2061cfdb-e779-4b63-ad8d-6c91d5f6c119
Hunter, Michael L
debb17fa-e00a-47fe-b752-d2d126ad4256
Imboden, Medea
7ac4495d-e803-4e18-b6ba-318da568f776
Jameson, Karen A
d5fb142d-06af-456e-9016-17497f94e9f2
Kerr, Shona M
627b1858-a1d1-4cbd-921b-8501ab39d4f3
Kolcic, Ivana
9689f967-2fbf-4c09-8e36-595c51a77275
Kronenberg, Florian
056e8fa9-c2f1-4d61-a849-19ad35ed5c34
Liu, Jason Z
4bda783a-84d2-4b32-9af6-9ce30c93fce7
Marchini, Jonathan
e98649d0-f4b6-4295-80e2-2eee6a97fc4e
McKeever, Tricia
b06bca95-4829-409f-8331-44d424f9c4b3
Morris, Andrew D
d6c7253e-8ab1-4394-a115-280d60e39845
Olin, Anna-Carin
2613f8f9-ce9e-4fec-b66d-8b84fb82e417
Porteous, David J
7c036c8c-866c-42e6-87b6-5412dd120de7
Postma, Dirkje S
cb6cd9ac-50b8-451d-b46f-7d7736946eed
Rich, Stephen S
9ab027e0-bda0-4947-9659-d5269337a469
Ring, Susan M
44a6327f-35c5-40d6-b0aa-11e4413b7f10
Rivadeneira, Fernando
8441b9d3-6d8e-4b33-8827-dd70d80db200
Rochat, Thierry
acba6b3d-a224-41e6-be94-f204e2d16f94
Sayer, Avan Aihie
fb4c2053-6d51-4fc1-9489-c3cb431b0ffb
Sayers, Ian
8595fc2e-102b-406c-ba26-269b8bdba786
Sly, Peter D
2e6acc16-8e7c-46fe-bba4-025ea0463f14
Smith, George Davey
f5bc8327-f2cb-49a0-8eae-4a6ba63207a2
Sood, Akshay
e6882905-7d01-4dc2-8571-2b7eaa649cbe
Starr, John M
7f9cb247-6a31-452e-9cfb-910a1b731a23
Uitterlinden, André G
3602fdd2-b484-4be5-91e6-403a281a43f7
Vonk, Judith M
8a2cadb9-0c50-4976-a718-6ccaa83a6b82
Wannamethee, S Goya
acedbe38-4ff8-4ebc-9ce7-e9737c4056d0
Whincup, Peter H
5aedc15b-5cfe-4e3a-8880-828da1b3abaf
Wijmenga, Cisca
3acbef11-8ba0-4cc8-bf0d-4046aece2e7d
Williams, O Dale
fb7db5cc-3eca-459c-b4d5-096ac8ac22aa
Wong, Andrew
64a5fd30-a16e-4fba-a4d9-8d3fffeaa8f9
Mangino, Massimo
19ad1660-3639-45a8-93d6-e6a9b5c1c64b
Marciante, Kristin D
e733ac6b-4c19-46b9-98c7-41127f0d5538
McArdle, Wendy L
60abb308-b0cb-45aa-8492-72ed9b3539b7
Meibohm, Bernd
aab34cee-df67-48a3-b1aa-e586116d7fa1
Morrison, Alanna C
6667cb2b-610f-4eb1-9e33-9cd21a731a34
North, Kari E
aa9af560-25a2-49ac-97d8-d1a6bada8412
Omenaas, Ernst
7ad62321-7087-4201-9f63-0d17d3f7d14a
Palmer, Lyle J
4004a1f8-01fa-4cb0-a846-7fb7b422a5a3
Pietiläinen, Kirsi H
c7091d90-95a7-4f95-98c5-c6532b558b39
Pin, Isabelle
73224fd9-fb5a-4792-8f21-ed0de15adaa1
Pola Sbreve Ek, Ozren
9aad1f60-384e-4ebe-ab30-da0e0045ad3b
Pouta, Anneli
108c5aa1-3b41-4095-91fa-ecd523934370
Psaty, Bruce M
f7ebcc9e-8b54-4704-8711-c658540b5cd2
Hartikainen, Anna-Liisa
f3af50ad-2846-4220-9cf8-9c535b9dd908
Rantanen, Taina
db75d4bf-e534-4909-8895-6777a9e2061f
Ripatti, Samuli
705fa391-c779-4941-814c-8ce1f8fbefb7
Rotter, Jerome I
2efb96a5-f0ce-4428-9ac8-fb762561c755
Rudan, Igor
89b94981-36be-463c-9068-fd2140b05903
Rudnicka, Alicja R
891dca88-1fd4-41ff-80bb-0d26f0fa9b36
Schulz, Holger
05d1d455-f27e-4e52-919f-08963742aabf
Shin, So-Youn
17f85485-0b29-42c3-b690-4817375be839
Spector, Tim D
965dbeb9-fc69-4283-b1a3-3aa1fcd38e96
Surakka, Ida
99141cb0-65ed-44eb-9ac0-ee5e30cc57bc
Vitart, Veronique
30073df8-6255-430e-a143-d600fa48bacd
Völzke, Henry
7a82b5da-95dd-4f33-9e7f-693e50ff19cb
Wareham, Nicholas J
e62762ff-10eb-4f15-b96a-c6b4f222f4e2
Warrington, Nicole M
b8baf55f-1bd8-45ae-ab97-cb2d582923ee
Wichmann, H-Erich
4628c10c-ff92-4eae-9ee8-7122efa70425
Wild, Sarah H
3b9da54e-590d-42b2-89a1-5ee51c2a13d8
Wilk, Jemma B
ed750c55-f012-45f2-8cc9-a3d44df66b9b
Wjst, Matthias
bb5da074-3243-4e82-a36b-197a4df5a2b8
Wright, Alan F
60e517d0-7e85-4e69-bdeb-926339a300dc
Zgaga, Lina
7b45db7b-b6d5-48b2-972a-f86325b209df
Zemunik, Tatijana
3d6027a5-5b90-41e5-9420-76593e4b1a4c
Pennell, Craig E
a17aa59a-ee38-4b50-943f-245755e5460c
Nyberg, Fredrik
6e5ecce8-308c-4854-b291-64ce8ebfd644
Kuh, Diana
4f3b51aa-21a0-4d68-be14-e1ed75448aaf
Holloway, John W
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Boezen, H Marike
934ce213-78b3-4472-8c66-b233a6374ccf
Lawlor, Debbie A
220a802a-1560-4433-b4fa-fadbc336b1f4
Morris, Richard W
cba363b1-3668-4159-89d1-25eac95a0ab0
Probst-Hensch, Nicole
33ee3cca-a1d4-4157-87c3-20ebfd84406f
Kaprio, Jaakko
de018b67-5b73-4c34-94af-8fbc4a4ff34d
Wilson, James F
a4770d88-8ec4-499f-8600-0539e35ea43c
Hayward, Caroline
8b58ae74-401a-4306-8b8f-c8414485131c
Kähönen, Mika
1155e797-98f0-4204-96be-b8f410155340
Heinrich, Joachim
bd0a5948-41cb-4541-87ad-1b86e51f6d2a
Musk, Arthur W
2367174a-fedc-46c4-bd4c-8c24eb48fb9c
Jarvis, Deborah L
9e8ece92-3265-42e4-9240-2beccacb00cd
Gläser, Sven
b5f08459-91cf-448b-ab80-46622a4c3988
Järvelin, Marjo-Riitta
eb1fa1c9-add7-4f22-b314-1548d28a286b
Ch Stricker, Bruno H
f0420356-d9d5-44bd-ad54-6362ce3c6161
Elliott, Paul
5e19ee8c-f18a-417e-ad53-bc807fdfd191
O'Connor, George T
330168be-4b3d-4948-be8a-3bd4273ed22f
Strachan, David P
8bd6230e-1a7b-4a85-bd5e-e13e08f760b2
London, Stephanie J
320afdd8-d870-49a0-9f68-b409fb522e85
Hall, Ian P
a58b8b48-5b81-41e1-9172-d490b1fe58a4
Gudnason, Vilmundur
75cefe2e-c5f6-4d85-9a92-cd8c29dd6a94
Tobin, Martin D
b732834c-d937-4f6a-a2eb-2669c118b167

Artigas, María Soler, Loth, Daan W, Wain, Louise V, Gharib, Sina A, Obeidat, Ma'en, Tang, Wenbo, Zhai, Guangju, Zhao, Jing Hua, Smith, Albert Vernon, Huffman, Jennifer E, Albrecht, Eva, Jackson, Catherine M, Evans, David M, Cadby, Gemma, Fornage, Myriam, Manichaikul, Ani, Lopez, Lorna M, Johnson, Toby, Aldrich, Melinda C, Aspelund, Thor, Barroso, Inês, Campbell, Harry, Cassano, Patricia A, Couper, David J, Eiriksdottir, Gudny, Franceschini, Nora, Garcia, Melissa, Gieger, Christian, Gislason, Gauti Kjartan, Grkovic, Ivica, Hammond, Christopher J, Hancock, Dana B, Harris, Tamara B, Ramasamy, Adaikalavan, Heckbert, Susan R, Heliövaara, Markku, Homuth, Georg, Hysi, Pirro G, James, Alan L, Jankovic, Stipan, Joubert, Bonnie R, Karrasch, Stefan, Klopp, Norman, Koch, Beate, Kritchevsky, Stephen B, Launer, Lenore J, Liu, Yongmei, Loehr, Laura R, Lohman, Kurt, Loos, Ruth J F, Lumley, Thomas, Al Balushi, Khalid A, Ang, Wei Q, Barr, R Graham, Beilby, John, Blakey, John D, Boban, Mladen, Boraska, Vesna, Brisman, Jonas, Britton, John R, Brusselle, Guy G, Cooper, Cyrus, Curjuric, Ivan, Dahgam, Santosh, Deary, Ian J, Ebrahim, Shah, Eijgelsheim, Mark, Francks, Clyde, Gaysina, Darya, Granell, Raquel, Gu, Xiangjun, Hankinson, John L, Hardy, Rebecca, Harris, Sarah E, Henderson, John, Henry, Amanda, Hingorani, Aroon D, Hofman, Albert, Holt, Patrick G, Hui, Jennie, Hunter, Michael L, Imboden, Medea, Jameson, Karen A, Kerr, Shona M, Kolcic, Ivana, Kronenberg, Florian, Liu, Jason Z, Marchini, Jonathan, McKeever, Tricia, Morris, Andrew D, Olin, Anna-Carin, Porteous, David J, Postma, Dirkje S, Rich, Stephen S, Ring, Susan M, Rivadeneira, Fernando, Rochat, Thierry, Sayer, Avan Aihie, Sayers, Ian, Sly, Peter D, Smith, George Davey, Sood, Akshay, Starr, John M, Uitterlinden, André G, Vonk, Judith M, Wannamethee, S Goya, Whincup, Peter H, Wijmenga, Cisca, Williams, O Dale, Wong, Andrew, Mangino, Massimo, Marciante, Kristin D, McArdle, Wendy L, Meibohm, Bernd, Morrison, Alanna C, North, Kari E, Omenaas, Ernst, Palmer, Lyle J, Pietiläinen, Kirsi H, Pin, Isabelle, Pola Sbreve Ek, Ozren, Pouta, Anneli, Psaty, Bruce M, Hartikainen, Anna-Liisa, Rantanen, Taina, Ripatti, Samuli, Rotter, Jerome I, Rudan, Igor, Rudnicka, Alicja R, Schulz, Holger, Shin, So-Youn, Spector, Tim D, Surakka, Ida, Vitart, Veronique, Völzke, Henry, Wareham, Nicholas J, Warrington, Nicole M, Wichmann, H-Erich, Wild, Sarah H, Wilk, Jemma B, Wjst, Matthias, Wright, Alan F, Zgaga, Lina, Zemunik, Tatijana, Pennell, Craig E, Nyberg, Fredrik, Kuh, Diana, Holloway, John W, Boezen, H Marike, Lawlor, Debbie A, Morris, Richard W, Probst-Hensch, Nicole, Kaprio, Jaakko, Wilson, James F, Hayward, Caroline, Kähönen, Mika, Heinrich, Joachim, Musk, Arthur W, Jarvis, Deborah L, Gläser, Sven, Järvelin, Marjo-Riitta, Ch Stricker, Bruno H, Elliott, Paul, O'Connor, George T, Strachan, David P, London, Stephanie J, Hall, Ian P, Gudnason, Vilmundur and Tobin, Martin D (2011) Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics, 43 (11), 1082-1090. (doi:10.1038/ng.941). (PMID:21946350)

Record type: Article

Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10?8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

This record has no associated files available for download.

More information

e-pub ahead of print date: 25 September 2011
Published date: 25 September 2011
Organisations: Human Development & Health, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 202485
URI: http://eprints.soton.ac.uk/id/eprint/202485
DOI: doi:10.1038/ng.941
ISSN: 1061-4036
PURE UUID: 6246b447-5b9b-4a8c-84b2-85e774b13729
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for John W Holloway: ORCID iD orcid.org/0000-0001-9998-0464

Catalogue record

Date deposited: 07 Dec 2011 14:40
Last modified: 18 Mar 2024 02:47

Export record

Altmetrics

Contributors

Author: María Soler Artigas
Author: Daan W Loth
Author: Louise V Wain
Author: Sina A Gharib
Author: Ma'en Obeidat
Author: Wenbo Tang
Author: Guangju Zhai
Author: Jing Hua Zhao
Author: Albert Vernon Smith
Author: Jennifer E Huffman
Author: Eva Albrecht
Author: Catherine M Jackson
Author: David M Evans
Author: Gemma Cadby
Author: Myriam Fornage
Author: Ani Manichaikul
Author: Lorna M Lopez
Author: Toby Johnson
Author: Melinda C Aldrich
Author: Thor Aspelund
Author: Inês Barroso
Author: Harry Campbell
Author: Patricia A Cassano
Author: David J Couper
Author: Gudny Eiriksdottir
Author: Nora Franceschini
Author: Melissa Garcia
Author: Christian Gieger
Author: Gauti Kjartan Gislason
Author: Ivica Grkovic
Author: Christopher J Hammond
Author: Dana B Hancock
Author: Tamara B Harris
Author: Adaikalavan Ramasamy
Author: Susan R Heckbert
Author: Markku Heliövaara
Author: Georg Homuth
Author: Pirro G Hysi
Author: Alan L James
Author: Stipan Jankovic
Author: Bonnie R Joubert
Author: Stefan Karrasch
Author: Norman Klopp
Author: Beate Koch
Author: Stephen B Kritchevsky
Author: Lenore J Launer
Author: Yongmei Liu
Author: Laura R Loehr
Author: Kurt Lohman
Author: Ruth J F Loos
Author: Thomas Lumley
Author: Khalid A Al Balushi
Author: Wei Q Ang
Author: R Graham Barr
Author: John Beilby
Author: John D Blakey
Author: Mladen Boban
Author: Vesna Boraska
Author: Jonas Brisman
Author: John R Britton
Author: Guy G Brusselle
Author: Cyrus Cooper ORCID iD
Author: Ivan Curjuric
Author: Santosh Dahgam
Author: Ian J Deary
Author: Shah Ebrahim
Author: Mark Eijgelsheim
Author: Clyde Francks
Author: Darya Gaysina
Author: Raquel Granell
Author: Xiangjun Gu
Author: John L Hankinson
Author: Rebecca Hardy
Author: Sarah E Harris
Author: John Henderson
Author: Amanda Henry
Author: Aroon D Hingorani
Author: Albert Hofman
Author: Patrick G Holt
Author: Jennie Hui
Author: Michael L Hunter
Author: Medea Imboden
Author: Karen A Jameson
Author: Shona M Kerr
Author: Ivana Kolcic
Author: Florian Kronenberg
Author: Jason Z Liu
Author: Jonathan Marchini
Author: Tricia McKeever
Author: Andrew D Morris
Author: Anna-Carin Olin
Author: David J Porteous
Author: Dirkje S Postma
Author: Stephen S Rich
Author: Susan M Ring
Author: Fernando Rivadeneira
Author: Thierry Rochat
Author: Avan Aihie Sayer
Author: Ian Sayers
Author: Peter D Sly
Author: George Davey Smith
Author: Akshay Sood
Author: John M Starr
Author: André G Uitterlinden
Author: Judith M Vonk
Author: S Goya Wannamethee
Author: Peter H Whincup
Author: Cisca Wijmenga
Author: O Dale Williams
Author: Andrew Wong
Author: Massimo Mangino
Author: Kristin D Marciante
Author: Wendy L McArdle
Author: Bernd Meibohm
Author: Alanna C Morrison
Author: Kari E North
Author: Ernst Omenaas
Author: Lyle J Palmer
Author: Kirsi H Pietiläinen
Author: Isabelle Pin
Author: Ozren Pola Sbreve Ek
Author: Anneli Pouta
Author: Bruce M Psaty
Author: Anna-Liisa Hartikainen
Author: Taina Rantanen
Author: Samuli Ripatti
Author: Jerome I Rotter
Author: Igor Rudan
Author: Alicja R Rudnicka
Author: Holger Schulz
Author: So-Youn Shin
Author: Tim D Spector
Author: Ida Surakka
Author: Veronique Vitart
Author: Henry Völzke
Author: Nicholas J Wareham
Author: Nicole M Warrington
Author: H-Erich Wichmann
Author: Sarah H Wild
Author: Jemma B Wilk
Author: Matthias Wjst
Author: Alan F Wright
Author: Lina Zgaga
Author: Tatijana Zemunik
Author: Craig E Pennell
Author: Fredrik Nyberg
Author: Diana Kuh
Author: John W Holloway ORCID iD
Author: H Marike Boezen
Author: Debbie A Lawlor
Author: Richard W Morris
Author: Nicole Probst-Hensch
Author: Jaakko Kaprio
Author: James F Wilson
Author: Caroline Hayward
Author: Mika Kähönen
Author: Joachim Heinrich
Author: Arthur W Musk
Author: Deborah L Jarvis
Author: Sven Gläser
Author: Marjo-Riitta Järvelin
Author: Bruno H Ch Stricker
Author: Paul Elliott
Author: George T O'Connor
Author: David P Strachan
Author: Stephanie J London
Author: Ian P Hall
Author: Vilmundur Gudnason
Author: Martin D Tobin

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Library staff additional information
Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×