The University of Southampton
University of Southampton Institutional Repository

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10?8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.
1061-4036
1082-1090
Artigas, María Soler
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Loth, Daan W
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Wain, Louise V
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Gharib, Sina A
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Obeidat, Ma'en
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Tang, Wenbo
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Zhai, Guangju
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Zhao, Jing Hua
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Smith, Albert Vernon
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Huffman, Jennifer E
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Albrecht, Eva
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Jackson, Catherine M
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Evans, David M
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Cadby, Gemma
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Lopez, Lorna M
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Johnson, Toby
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Aldrich, Melinda C
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Aspelund, Thor
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Barroso, Inês
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Campbell, Harry
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Gieger, Christian
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Grkovic, Ivica
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Hammond, Christopher J
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Ramasamy, Adaikalavan
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Heckbert, Susan R
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Karrasch, Stefan
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Kritchevsky, Stephen B
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Liu, Yongmei
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Lumley, Thomas
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Gu, Xiangjun
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Imboden, Medea
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Kerr, Shona M
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Lumley, Thomas
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Marciante, Kristin D
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McArdle, Wendy L
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Meibohm, Bernd
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Morrison, Alanna C
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North, Kari E
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Pouta, Anneli
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Psaty, Bruce M
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Hartikainen, Anna-Liisa
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Rotter, Jerome I
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Rudan, Igor
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Rudnicka, Alicja R
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Artigas, María Soler, Loth, Daan W, Wain, Louise V, Gharib, Sina A, Obeidat, Ma'en, Tang, Wenbo, Zhai, Guangju, Zhao, Jing Hua, Smith, Albert Vernon, Huffman, Jennifer E, Albrecht, Eva, Jackson, Catherine M, Evans, David M, Cadby, Gemma, Fornage, Myriam, Manichaikul, Ani, Lopez, Lorna M, Johnson, Toby, Aldrich, Melinda C, Aspelund, Thor, Barroso, Inês, Campbell, Harry, Cassano, Patricia A, Couper, David J, Eiriksdottir, Gudny, Franceschini, Nora, Garcia, Melissa, Gieger, Christian, Gislason, Gauti Kjartan, Grkovic, Ivica, Hammond, Christopher J, Hancock, Dana B, Harris, Tamara B, Ramasamy, Adaikalavan, Heckbert, Susan R, Heliövaara, Markku, Homuth, Georg, Hysi, Pirro G, James, Alan L, Jankovic, Stipan, Joubert, Bonnie R, Karrasch, Stefan, Klopp, Norman, Koch, Beate, Kritchevsky, Stephen B, Launer, Lenore J, Liu, Yongmei, Loehr, Laura R, Lohman, Kurt, Loos, Ruth J F, Lumley, Thomas, Al Balushi, Khalid A, Ang, Wei Q, Barr, R Graham, Beilby, John, Blakey, John D, Boban, Mladen, Boraska, Vesna, Brisman, Jonas, Britton, John R, Brusselle, Guy G, Cooper, Cyrus, Curjuric, Ivan, Dahgam, Santosh, Deary, Ian J, Ebrahim, Shah, Eijgelsheim, Mark, Francks, Clyde, Gaysina, Darya, Granell, Raquel, Gu, Xiangjun, Hankinson, John L, Hardy, Rebecca, Harris, Sarah E, Henderson, John, Henry, Amanda, Hingorani, Aroon D, Hofman, Albert, Holt, Patrick G, Hui, Jennie, Hunter, Michael L, Imboden, Medea, Jameson, Karen A, Kerr, Shona M, Kolcic, Ivana, Kronenberg, Florian, Liu, Jason Z, Marchini, Jonathan, McKeever, Tricia, Morris, Andrew D, Olin, Anna-Carin, Porteous, David J, Postma, Dirkje S, Rich, Stephen S, Ring, Susan M, Rivadeneira, Fernando, Rochat, Thierry, Sayer, Avan Aihie, Sayers, Ian, Sly, Peter D, Smith, George Davey, Sood, Akshay, Starr, John M, Uitterlinden, André G, Vonk, Judith M, Wannamethee, S Goya, Whincup, Peter H, Wijmenga, Cisca, Williams, O Dale, Wong, Andrew, Mangino, Massimo, Marciante, Kristin D, McArdle, Wendy L, Meibohm, Bernd, Morrison, Alanna C, North, Kari E, Omenaas, Ernst, Palmer, Lyle J, Pietiläinen, Kirsi H, Pin, Isabelle, Pola Sbreve Ek, Ozren, Pouta, Anneli, Psaty, Bruce M, Hartikainen, Anna-Liisa, Rantanen, Taina, Ripatti, Samuli, Rotter, Jerome I, Rudan, Igor, Rudnicka, Alicja R, Schulz, Holger, Shin, So-Youn, Spector, Tim D, Surakka, Ida, Vitart, Veronique, Völzke, Henry, Wareham, Nicholas J, Warrington, Nicole M, Wichmann, H-Erich, Wild, Sarah H, Wilk, Jemma B, Wjst, Matthias, Wright, Alan F, Zgaga, Lina, Zemunik, Tatijana, Pennell, Craig E, Nyberg, Fredrik, Kuh, Diana, Holloway, John W, Boezen, H Marike, Lawlor, Debbie A, Morris, Richard W, Probst-Hensch, Nicole, Kaprio, Jaakko, Wilson, James F, Hayward, Caroline, Kähönen, Mika, Heinrich, Joachim, Musk, Arthur W, Jarvis, Deborah L, Gläser, Sven, Järvelin, Marjo-Riitta, Ch Stricker, Bruno H, Elliott, Paul, O'Connor, George T, Strachan, David P, London, Stephanie J, Hall, Ian P, Gudnason, Vilmundur and Tobin, Martin D (2011) Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nature Genetics, 43 (11), 1082-1090. (doi:10.1038/ng.941). (PMID:21946350)

Record type: Article

Abstract

Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. We tested genome-wide association with forced expiratory volume in 1 second and the ratio of forced expiratory volume in 1 second to forced vital capacity in 48,201 individuals of European ancestry with follow up of the top associations in up to an additional 46,411 individuals. We identified new regions showing association (combined P < 5 × 10?8) with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2. Identification of these 16 new loci may provide insight into the molecular mechanisms regulating pulmonary function and into molecular targets for future therapy to alleviate reduced lung function.

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e-pub ahead of print date: 25 September 2011
Published date: 25 September 2011
Organisations: Human Development & Health, Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 202485
URI: https://eprints.soton.ac.uk/id/eprint/202485
ISSN: 1061-4036
PURE UUID: 6246b447-5b9b-4a8c-84b2-85e774b13729
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for John W Holloway: ORCID iD orcid.org/0000-0001-9998-0464

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Date deposited: 07 Dec 2011 14:40
Last modified: 05 Nov 2019 01:59

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Contributors

Author: María Soler Artigas
Author: Daan W Loth
Author: Louise V Wain
Author: Sina A Gharib
Author: Ma'en Obeidat
Author: Wenbo Tang
Author: Guangju Zhai
Author: Jing Hua Zhao
Author: Albert Vernon Smith
Author: Jennifer E Huffman
Author: Eva Albrecht
Author: Catherine M Jackson
Author: David M Evans
Author: Gemma Cadby
Author: Myriam Fornage
Author: Ani Manichaikul
Author: Lorna M Lopez
Author: Toby Johnson
Author: Melinda C Aldrich
Author: Thor Aspelund
Author: Inês Barroso
Author: Harry Campbell
Author: Patricia A Cassano
Author: David J Couper
Author: Gudny Eiriksdottir
Author: Nora Franceschini
Author: Melissa Garcia
Author: Christian Gieger
Author: Gauti Kjartan Gislason
Author: Ivica Grkovic
Author: Christopher J Hammond
Author: Dana B Hancock
Author: Tamara B Harris
Author: Adaikalavan Ramasamy
Author: Susan R Heckbert
Author: Markku Heliövaara
Author: Georg Homuth
Author: Pirro G Hysi
Author: Alan L James
Author: Stipan Jankovic
Author: Bonnie R Joubert
Author: Stefan Karrasch
Author: Norman Klopp
Author: Beate Koch
Author: Stephen B Kritchevsky
Author: Lenore J Launer
Author: Yongmei Liu
Author: Laura R Loehr
Author: Kurt Lohman
Author: Ruth J F Loos
Author: Thomas Lumley
Author: Khalid A Al Balushi
Author: Wei Q Ang
Author: R Graham Barr
Author: John Beilby
Author: John D Blakey
Author: Mladen Boban
Author: Vesna Boraska
Author: Jonas Brisman
Author: John R Britton
Author: Guy G Brusselle
Author: Cyrus Cooper ORCID iD
Author: Ivan Curjuric
Author: Santosh Dahgam
Author: Ian J Deary
Author: Shah Ebrahim
Author: Mark Eijgelsheim
Author: Clyde Francks
Author: Darya Gaysina
Author: Raquel Granell
Author: Xiangjun Gu
Author: John L Hankinson
Author: Rebecca Hardy
Author: Sarah E Harris
Author: John Henderson
Author: Amanda Henry
Author: Aroon D Hingorani
Author: Albert Hofman
Author: Patrick G Holt
Author: Jennie Hui
Author: Michael L Hunter
Author: Medea Imboden
Author: Karen A Jameson
Author: Shona M Kerr
Author: Ivana Kolcic
Author: Florian Kronenberg
Author: Jason Z Liu
Author: Jonathan Marchini
Author: Tricia McKeever
Author: Andrew D Morris
Author: Anna-Carin Olin
Author: David J Porteous
Author: Dirkje S Postma
Author: Stephen S Rich
Author: Susan M Ring
Author: Fernando Rivadeneira
Author: Thierry Rochat
Author: Ian Sayers
Author: Peter D Sly
Author: George Davey Smith
Author: Akshay Sood
Author: John M Starr
Author: André G Uitterlinden
Author: Judith M Vonk
Author: S Goya Wannamethee
Author: Peter H Whincup
Author: Cisca Wijmenga
Author: O Dale Williams
Author: Andrew Wong
Author: Massimo Mangino
Author: Kristin D Marciante
Author: Wendy L McArdle
Author: Bernd Meibohm
Author: Alanna C Morrison
Author: Kari E North
Author: Ernst Omenaas
Author: Lyle J Palmer
Author: Kirsi H Pietiläinen
Author: Isabelle Pin
Author: Ozren Pola Sbreve Ek
Author: Anneli Pouta
Author: Bruce M Psaty
Author: Anna-Liisa Hartikainen
Author: Taina Rantanen
Author: Samuli Ripatti
Author: Jerome I Rotter
Author: Igor Rudan
Author: Alicja R Rudnicka
Author: Holger Schulz
Author: So-Youn Shin
Author: Tim D Spector
Author: Ida Surakka
Author: Veronique Vitart
Author: Henry Völzke
Author: Nicholas J Wareham
Author: Nicole M Warrington
Author: H-Erich Wichmann
Author: Sarah H Wild
Author: Jemma B Wilk
Author: Matthias Wjst
Author: Alan F Wright
Author: Lina Zgaga
Author: Tatijana Zemunik
Author: Craig E Pennell
Author: Fredrik Nyberg
Author: Diana Kuh
Author: John W Holloway ORCID iD
Author: H Marike Boezen
Author: Debbie A Lawlor
Author: Richard W Morris
Author: Nicole Probst-Hensch
Author: Jaakko Kaprio
Author: James F Wilson
Author: Caroline Hayward
Author: Mika Kähönen
Author: Joachim Heinrich
Author: Arthur W Musk
Author: Deborah L Jarvis
Author: Sven Gläser
Author: Marjo-Riitta Järvelin
Author: Bruno H Ch Stricker
Author: Paul Elliott
Author: George T O'Connor
Author: David P Strachan
Author: Stephanie J London
Author: Ian P Hall
Author: Vilmundur Gudnason
Author: Martin D Tobin

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