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Thiol-mediated free radical cyclisations of isocyanides on solid support

Thiol-mediated free radical cyclisations of isocyanides on solid support
Thiol-mediated free radical cyclisations of isocyanides on solid support
Three novel polymer-supported isocyanides have been synthesised, from commercial Wang and HMBA-AM resins, and reacted under radical conditions with 2-mercaptoethanol and ethanethiol to give the corresponding pyrrolidine or pyroglutamic acid derivatives in good yields.
alkynyl isocyanides, peptide-synthesis, isonitriles, phase, alkenyl, acid, (+/-)-camptothecin, annulations, derivatives, route
0040-4039
8541-8543
Lamberto, M.
16196442-c0c6-45e8-81e9-6fbe2682831b
Corbett, D. F.
190a157e-fbea-4f98-9885-7f81ffa1b3eb
Kilburn, J. D.
c02957da-baca-4138-961a-a85170d11dd8
Lamberto, M.
16196442-c0c6-45e8-81e9-6fbe2682831b
Corbett, D. F.
190a157e-fbea-4f98-9885-7f81ffa1b3eb
Kilburn, J. D.
c02957da-baca-4138-961a-a85170d11dd8

Lamberto, M., Corbett, D. F. and Kilburn, J. D. (2004) Thiol-mediated free radical cyclisations of isocyanides on solid support. Tetrahedron Letters, 45 (46), 8541-8543. (doi:10.1016/j.tetlet.2004.09.078).

Record type: Article

Abstract

Three novel polymer-supported isocyanides have been synthesised, from commercial Wang and HMBA-AM resins, and reacted under radical conditions with 2-mercaptoethanol and ethanethiol to give the corresponding pyrrolidine or pyroglutamic acid derivatives in good yields.

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More information

Published date: 8 November 2004
Keywords: alkynyl isocyanides, peptide-synthesis, isonitriles, phase, alkenyl, acid, (+/-)-camptothecin, annulations, derivatives, route
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Identifiers

Local EPrints ID: 20261
URI: http://eprints.soton.ac.uk/id/eprint/20261
DOI: doi:10.1016/j.tetlet.2004.09.078
ISSN: 0040-4039
PURE UUID: 1bf41dfe-c42d-4f27-9cf7-c6bdfc094b38

Catalogue record

Date deposited: 20 Feb 2006
Last modified: 15 Mar 2024 06:23

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Contributors

Author: M. Lamberto
Author: D. F. Corbett
Author: J. D. Kilburn

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