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Thiol-mediated free radical cyclisations of isocyanides on solid support

Lamberto, M., Corbett, D. F. and Kilburn, J. D. (2004) Thiol-mediated free radical cyclisations of isocyanides on solid support Tetrahedron Letters, 45, (46), pp. 8541-8543. (doi:10.1016/j.tetlet.2004.09.078).

Record type: Article


Three novel polymer-supported isocyanides have been synthesised, from commercial Wang and HMBA-AM resins, and reacted under radical conditions with 2-mercaptoethanol and ethanethiol to give the corresponding pyrrolidine or pyroglutamic acid derivatives in good yields.

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Published date: 8 November 2004
Keywords: alkynyl isocyanides, peptide-synthesis, isonitriles, phase, alkenyl, acid, (+/-)-camptothecin, annulations, derivatives, route


Local EPrints ID: 20261
ISSN: 0040-4039
PURE UUID: 1bf41dfe-c42d-4f27-9cf7-c6bdfc094b38

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Date deposited: 20 Feb 2006
Last modified: 17 Jul 2017 16:29

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Author: M. Lamberto
Author: D. F. Corbett
Author: J. D. Kilburn

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