Neonatal magnetic resonance imaging and outcome at age 30 months in extremely preterm infants
Neonatal magnetic resonance imaging and outcome at age 30 months in extremely preterm infants
OBJECTIVE: To examine associations between brain white matter abnormalities, including diffuse excessive high signal intensities, detected on neonatal magnetic resonance imaging (MRI) with neurodevelopmental outcome at age 30 months. STUDY DESIGN: This was a prospective, population-based study of infants born at <27 weeks gestation (n=117) undergoing conventional MRI at term equivalent age (n=107). At age 30 months corrected, 91 of the preterm infants (78%) and 85 term-born controls were assessed with the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). RESULTS: Cerebral palsy (CP) was present in 7% of the preterm group. On the BSID-III, mean composite scores were 96±9.5 for the cognitive scale, 97±14 for language scales, and 103±15 for motor scales, all within the normal range for age. Compared with the term-born controls, however, the preterm infants did not perform as well on all 3 scales, also when MRI was normal. Significant associations were seen between moderate to severe white matter abnormalities and CP (P<.001). The presence of diffuse excessive high signal intensities was not associated with performance on the BSID-III or with CP. CONCLUSION: This 3-year cohort of extremely preterm infants had low rates of major brain injury and impaired outcome. Neonatal MRI provides useful information, but this information needs to be treated with caution when predicting outcome.
599-566
Skiöld, Béatrice
e0462ec7-9993-47b5-92bb-3db4edf06d2d
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Böhm, Birgitta
18786995-861a-454e-9957-e8a23cc26719
Hallberg, Boubou
afac0039-8dc9-45c5-a695-4778134abfb1
Horsch, Sandra
7d161f85-dc40-4ab9-bd18-bb8903600e5b
Mosskin, Mikael
934dcb87-ada3-4959-8dc8-290e97a72608
Lagercrantz, Hugo
52c0701c-d6c3-4807-aa61-436fdf9f0d03
Adén, Ulrika
32b79481-167d-47f1-9e38-c332da320a33
Blennow, Mats
14d9f9ca-4587-4372-b964-463355551e31
April 2012
Skiöld, Béatrice
e0462ec7-9993-47b5-92bb-3db4edf06d2d
Vollmer, Brigitte
044f8b55-ba36-4fb2-8e7e-756ab77653ba
Böhm, Birgitta
18786995-861a-454e-9957-e8a23cc26719
Hallberg, Boubou
afac0039-8dc9-45c5-a695-4778134abfb1
Horsch, Sandra
7d161f85-dc40-4ab9-bd18-bb8903600e5b
Mosskin, Mikael
934dcb87-ada3-4959-8dc8-290e97a72608
Lagercrantz, Hugo
52c0701c-d6c3-4807-aa61-436fdf9f0d03
Adén, Ulrika
32b79481-167d-47f1-9e38-c332da320a33
Blennow, Mats
14d9f9ca-4587-4372-b964-463355551e31
Skiöld, Béatrice, Vollmer, Brigitte, Böhm, Birgitta, Hallberg, Boubou, Horsch, Sandra, Mosskin, Mikael, Lagercrantz, Hugo, Adén, Ulrika and Blennow, Mats
(2012)
Neonatal magnetic resonance imaging and outcome at age 30 months in extremely preterm infants.
Journal of Pediatrics, 160 (4), .
(doi:10.1016/j.jpeds.2011.09.053).
(PMID:22056283)
Abstract
OBJECTIVE: To examine associations between brain white matter abnormalities, including diffuse excessive high signal intensities, detected on neonatal magnetic resonance imaging (MRI) with neurodevelopmental outcome at age 30 months. STUDY DESIGN: This was a prospective, population-based study of infants born at <27 weeks gestation (n=117) undergoing conventional MRI at term equivalent age (n=107). At age 30 months corrected, 91 of the preterm infants (78%) and 85 term-born controls were assessed with the Bayley Scales of Infant and Toddler Development, Third Edition (BSID-III). RESULTS: Cerebral palsy (CP) was present in 7% of the preterm group. On the BSID-III, mean composite scores were 96±9.5 for the cognitive scale, 97±14 for language scales, and 103±15 for motor scales, all within the normal range for age. Compared with the term-born controls, however, the preterm infants did not perform as well on all 3 scales, also when MRI was normal. Significant associations were seen between moderate to severe white matter abnormalities and CP (P<.001). The presence of diffuse excessive high signal intensities was not associated with performance on the BSID-III or with CP. CONCLUSION: This 3-year cohort of extremely preterm infants had low rates of major brain injury and impaired outcome. Neonatal MRI provides useful information, but this information needs to be treated with caution when predicting outcome.
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Published date: April 2012
Organisations:
Clinical & Experimental Sciences
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Local EPrints ID: 202677
URI: http://eprints.soton.ac.uk/id/eprint/202677
ISSN: 0022-3476
PURE UUID: b18d77a8-79e9-4da5-bdc1-9acd6408521f
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Date deposited: 08 Nov 2011 14:40
Last modified: 15 Mar 2024 03:36
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Author:
Béatrice Skiöld
Author:
Birgitta Böhm
Author:
Boubou Hallberg
Author:
Sandra Horsch
Author:
Mikael Mosskin
Author:
Hugo Lagercrantz
Author:
Ulrika Adén
Author:
Mats Blennow
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