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Association between DHEAS and bone loss in postmenopausal women: a 15-year longitudinal population-based study

Ghebre, Michael A., Hart, Deborah J., Hakim, Alan J., Kato, Bernet S., Thompson, Vicky, Arden, Nigel K., Spector, Tim D. and Zhai, Guangju (2011) Association between DHEAS and bone loss in postmenopausal women: a 15-year longitudinal population-based study Calcified Tissue International, 89, (4), pp. 295-302. (doi:10.1007/s00223-011-9518-9). (PMID:21789637).

Record type: Article

Abstract

Our aim was to examine the association between serum dehydroepiandrosterone sulfate (DHEAS) at baseline and BMD change at the femoral neck (FN) and lumbar spine (LS) in postmenopausal women during a 15-year follow-up. All participants were from the Chingford Study. BMD at the FN and LS were measured eight times during the 15-year follow-up by dual-energy X-ray absorptiometry. DHEAS at baseline was measured using radioimmunoassay. Data on height, weight, and hormonereplacement therapy (HRT) status were obtained at each visit. Multilevel linear regression modeling was used to examine the association between longitudinal BMD change at the FN and LS and DHEAS at baseline. Postmenopausal women (n = 1,003) aged 45–68 years (mean 54.7) at baseline were included in the study. After adjustment for baseline age, estradiol, HRT, and BMI, BMD at the FN decreased on average 0.49% (95% CI 0.31–0.71%) per year; and the decline was slowed down by 0.028% per squared year. Increase of DHEAS (each micromole per liter) was associated with 0.49% less bone loss at the FN (95% CI 0.21–0.71%, P = 0.001). However, this strong association became slightly weaker over time. Similar but weaker results were obtained for LS BMD. Our data suggest that high serum DHEAS at baseline is associated with less bone loss at both FN and LS and this association diminishes over time. The nature of the association is unclear, but such an association implies that, in managing BMD loss, women might benefit from maintaining a high level of DHEAS.

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More information

e-pub ahead of print date: 26 July 2011
Published date: October 2011
Keywords: bmd, dheas, osteoporosis, longitudinal study, postmenopausal
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 202707
URI: http://eprints.soton.ac.uk/id/eprint/202707
ISSN: 0171-967X
PURE UUID: 11faeb88-5efe-4a75-aaa6-469018d9fdeb

Catalogue record

Date deposited: 09 Nov 2011 10:06
Last modified: 18 Jul 2017 11:10

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Contributors

Author: Michael A. Ghebre
Author: Deborah J. Hart
Author: Alan J. Hakim
Author: Bernet S. Kato
Author: Vicky Thompson
Author: Nigel K. Arden
Author: Tim D. Spector
Author: Guangju Zhai

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