Distance dependence of interactions between charged centres in proteins with common structural features
Distance dependence of interactions between charged centres in proteins with common structural features
Data collected for interactions among redox centres, and interactions between redox centres and acid-base residues in a family of small multihaem cytochromes are analysed. The distance dependent attenuation of the interactions between non-surface charges, for separations that range from 8 to 23 (A) over circle, can be described by a simple function derived from the DebyeHuckel formalism, fit to 9.5 and 7.6 as values for the relative dielectric constant and Debye length, respectively. However, there is considerable scatter in the data despite the structural similarities among the proteins, which is discussed in the framework of using such simple models in predicting properties of novel proteins.
electrostatic interactions, redox potentials, dielectric furction, debye-huckel, hill factor, cytochromesvulgaris miyazaki-f, cytochrome c(3), shewanella-frigidimarina, desulfovibrio-africanus, ionizable groups, heme-proteins, atomic detail, ooperativity
77-80
Louro, Ricardo O.
8014cf88-eb58-4ecd-8e04-8ce90a4e43f6
Catarino, Teresa
608a4400-1611-4798-bf27-7472e7c6a476
Paquete, Catarina M.
505734a6-bb69-4243-be1e-b78df93870c2
Turner, David L.
6c4c1ccb-a6f2-47cf-944e-e69269198a29
8 October 2004
Louro, Ricardo O.
8014cf88-eb58-4ecd-8e04-8ce90a4e43f6
Catarino, Teresa
608a4400-1611-4798-bf27-7472e7c6a476
Paquete, Catarina M.
505734a6-bb69-4243-be1e-b78df93870c2
Turner, David L.
6c4c1ccb-a6f2-47cf-944e-e69269198a29
Louro, Ricardo O., Catarino, Teresa, Paquete, Catarina M. and Turner, David L.
(2004)
Distance dependence of interactions between charged centres in proteins with common structural features.
FEBS Letters, 576 (1-2), .
(doi:10.1016/j.febslet.2004.08.066).
Abstract
Data collected for interactions among redox centres, and interactions between redox centres and acid-base residues in a family of small multihaem cytochromes are analysed. The distance dependent attenuation of the interactions between non-surface charges, for separations that range from 8 to 23 (A) over circle, can be described by a simple function derived from the DebyeHuckel formalism, fit to 9.5 and 7.6 as values for the relative dielectric constant and Debye length, respectively. However, there is considerable scatter in the data despite the structural similarities among the proteins, which is discussed in the framework of using such simple models in predicting properties of novel proteins.
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Published date: 8 October 2004
Keywords:
electrostatic interactions, redox potentials, dielectric furction, debye-huckel, hill factor, cytochromesvulgaris miyazaki-f, cytochrome c(3), shewanella-frigidimarina, desulfovibrio-africanus, ionizable groups, heme-proteins, atomic detail, ooperativity
Identifiers
Local EPrints ID: 20278
URI: http://eprints.soton.ac.uk/id/eprint/20278
ISSN: 0014-5793
PURE UUID: 3eec20b3-27dc-4679-a40f-032364c7b4ec
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Date deposited: 20 Feb 2006
Last modified: 15 Mar 2024 06:23
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Contributors
Author:
Ricardo O. Louro
Author:
Teresa Catarino
Author:
Catarina M. Paquete
Author:
David L. Turner
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