Experimental design and the optimization of a polymer supported palladium complex for use in the Heck reaction
Experimental design and the optimization of a polymer supported palladium complex for use in the Heck reaction
Optimization of the Heck reaction of 4-bromoacetophenone with styrene by a polymer supported, sulfur-containing palladacycle, varying 6 factors at a total of 28 different levels, corresponding to 5760 different possibilities was undertaken. Conversion improved from 34%, with large observable leaching to 88% with no leaching. This was accomplished using a Design of Experiments approach facilitated by the Statistical Design Package, MODDE 7.0(TM).
design, polymer, supported, palladium, recoverable catalysts, statistical design, chemistry, reagents, efficiency
8239-8243
McNamara, Catherine A.
30929cbe-5547-4dd4-871a-59d6dc45731c
King, Frank
657c50d7-5cbd-408a-a581-f9e286ed4d3a
Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900
25 October 2004
McNamara, Catherine A.
30929cbe-5547-4dd4-871a-59d6dc45731c
King, Frank
657c50d7-5cbd-408a-a581-f9e286ed4d3a
Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900
McNamara, Catherine A., King, Frank and Bradley, Mark
(2004)
Experimental design and the optimization of a polymer supported palladium complex for use in the Heck reaction.
Tetrahedron Letters, 45 (44), .
(doi:10.1016/j.tetlet.2004.09.016).
Abstract
Optimization of the Heck reaction of 4-bromoacetophenone with styrene by a polymer supported, sulfur-containing palladacycle, varying 6 factors at a total of 28 different levels, corresponding to 5760 different possibilities was undertaken. Conversion improved from 34%, with large observable leaching to 88% with no leaching. This was accomplished using a Design of Experiments approach facilitated by the Statistical Design Package, MODDE 7.0(TM).
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Published date: 25 October 2004
Keywords:
design, polymer, supported, palladium, recoverable catalysts, statistical design, chemistry, reagents, efficiency
Identifiers
Local EPrints ID: 20287
URI: http://eprints.soton.ac.uk/id/eprint/20287
ISSN: 0040-4039
PURE UUID: c03c8aaf-9196-464d-9d4e-e033e133e19f
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Date deposited: 20 Feb 2006
Last modified: 15 Mar 2024 06:23
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Author:
Catherine A. McNamara
Author:
Frank King
Author:
Mark Bradley
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