Natural products and combinatorial chemistry: back to the future
Natural products and combinatorial chemistry: back to the future
The introduction of high-throughput synthesis and combinatorial chemistry has precipitated a global decline in the screening of natural products by the pharmaceutical industry. Some companies terminated their natural products program, despite the unproven success of the new technologies. This was a premature decision, as natural products have a long history of providing important medicinal agents. Furthermore, they occupy a complementary region of chemical space compared with the typical synthetic compound library. For these reasons, the interest in natural products has been rekindled. Various approaches have evolved that combine the power of natural products and organic chemistry, ranging from the combinatorial total synthesis of analogues to the exploration of natural product scaffolds and the design of completely unnatural molecules that resemble natural products in their molecular characteristics.
vancomycin-resistant bacteria, drug discovery, solid-phase, privileged
structures, biological-properties, compound libraries, epothiloneanalogs, organic-synthesis, design, diversity
271-280
Ortholand, Jean-Yves
dda9e50b-cbc1-42f6-a9cc-254677e71d17
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9
1 June 2004
Ortholand, Jean-Yves
dda9e50b-cbc1-42f6-a9cc-254677e71d17
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9
Ortholand, Jean-Yves and Ganesan, A.
(2004)
Natural products and combinatorial chemistry: back to the future.
Current Opinion in Chemical Biology, 8 (3), .
(doi:10.1016/j.cbpa.2004.04.011).
Abstract
The introduction of high-throughput synthesis and combinatorial chemistry has precipitated a global decline in the screening of natural products by the pharmaceutical industry. Some companies terminated their natural products program, despite the unproven success of the new technologies. This was a premature decision, as natural products have a long history of providing important medicinal agents. Furthermore, they occupy a complementary region of chemical space compared with the typical synthetic compound library. For these reasons, the interest in natural products has been rekindled. Various approaches have evolved that combine the power of natural products and organic chemistry, ranging from the combinatorial total synthesis of analogues to the exploration of natural product scaffolds and the design of completely unnatural molecules that resemble natural products in their molecular characteristics.
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Published date: 1 June 2004
Keywords:
vancomycin-resistant bacteria, drug discovery, solid-phase, privileged
structures, biological-properties, compound libraries, epothiloneanalogs, organic-synthesis, design, diversity
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Local EPrints ID: 20297
URI: http://eprints.soton.ac.uk/id/eprint/20297
ISSN: 1367-5931
PURE UUID: 75c20ef2-d4fc-4045-9d52-cccd63ea8ed4
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Date deposited: 20 Feb 2006
Last modified: 15 Mar 2024 06:23
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Author:
Jean-Yves Ortholand
Author:
A. Ganesan
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