Carbohydrate-based therapeutics
Carbohydrate-based therapeutics
In recent years there has been a resurgence of interest in the biological roles of carbohydrates and as a result it is now known that carbohydrates are involved in a vast array of disease processes. This review summarises progress in the development of carbohydrate-based therapeutics that involve: inhibition of carbohydrate-lectin interactions; immunisation, using monoclonal antibodies for carbohydrate antigens; inhibition of enzymes that synthesise disease-associated carbohydrates; replacement of carbohydrate-processing enzymes; targeting of drugs to specific disease cells via carbohydrate-lectin interactions; carbohydrate based anti-thrombotic agents.
phase oligosaccharide synthesis, glycosidase inhibitors, capsular polysaccharide, advanced malignancies, clinical-applications, antiinfective agents, tumor-metastasis, anticancer drugs, cancer vaccines, cells
691-702
Osborn, H.M.I.
8de5773c-01a0-41a6-9d43-b14695a65b20
Evans, P.G.
46ce0fbf-d5a5-4aa5-b072-821e53d38296
Gemmell, N.
132018aa-5584-495c-a120-659431a932db
Osborne, S.D.
c97af1e5-d416-4e75-b729-84a190ae1fc6
1 June 2004
Osborn, H.M.I.
8de5773c-01a0-41a6-9d43-b14695a65b20
Evans, P.G.
46ce0fbf-d5a5-4aa5-b072-821e53d38296
Gemmell, N.
132018aa-5584-495c-a120-659431a932db
Osborne, S.D.
c97af1e5-d416-4e75-b729-84a190ae1fc6
Osborn, H.M.I., Evans, P.G., Gemmell, N. and Osborne, S.D.
(2004)
Carbohydrate-based therapeutics.
Journal of Pharmacy and Pharmacology, 56 (6), .
(doi:10.1211/0022357023619).
Abstract
In recent years there has been a resurgence of interest in the biological roles of carbohydrates and as a result it is now known that carbohydrates are involved in a vast array of disease processes. This review summarises progress in the development of carbohydrate-based therapeutics that involve: inhibition of carbohydrate-lectin interactions; immunisation, using monoclonal antibodies for carbohydrate antigens; inhibition of enzymes that synthesise disease-associated carbohydrates; replacement of carbohydrate-processing enzymes; targeting of drugs to specific disease cells via carbohydrate-lectin interactions; carbohydrate based anti-thrombotic agents.
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Published date: 1 June 2004
Additional Information:
Review article
Keywords:
phase oligosaccharide synthesis, glycosidase inhibitors, capsular polysaccharide, advanced malignancies, clinical-applications, antiinfective agents, tumor-metastasis, anticancer drugs, cancer vaccines, cells
Identifiers
Local EPrints ID: 20298
URI: http://eprints.soton.ac.uk/id/eprint/20298
ISSN: 0022-3573
PURE UUID: 3ea0392a-a26a-43c5-a310-d7c4209ab3dc
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Date deposited: 17 Feb 2006
Last modified: 15 Mar 2024 06:23
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Contributors
Author:
H.M.I. Osborn
Author:
P.G. Evans
Author:
N. Gemmell
Author:
S.D. Osborne
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