Chemical modification and micropatterning of Si(100) with oligonucleotides
Chemical modification and micropatterning of Si(100) with oligonucleotides
A method for the reliable attachment. of oligonucleotides to silicon (10 0) surfaces in patterns is described. LTV light exposure of silicon (10 0) coated with alkenes functionalized with carboxylic acid groups and derivatives results in covalent attachment to the silicon surface. The carboxyl-terminated (and derivatives) surfaces act as a substrate for the chemistry of the subsequent attachment of oligonucleotides. Illustrated are our results gained for optimisation of the surface attachment chemistry and the characterisation of the surface with scanning electron microscopy, epifluorescence microscopy and ellipsometry.
silicon functionalisation, oligonucleotide, conjugation, surfaceattachment chemistryself-assembled monolayers, alkyl monolayers, surfaces, silicon, 1-alkenes, proteins, cells, gold
830-836
Yin, H.B.
80f33a1f-d886-4f09-adab-bc65e9125c29
Brown, T.
a64aae36-bb30-42df-88a2-11be394e8c89
Greef, R.
91063544-ed89-4738-b5f4-28a984bf5866
Wilkinson, J.S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Melvin, T.
fd87f5eb-2bb9-48fa-b7be-7100ace9c50f
1 June 2004
Yin, H.B.
80f33a1f-d886-4f09-adab-bc65e9125c29
Brown, T.
a64aae36-bb30-42df-88a2-11be394e8c89
Greef, R.
91063544-ed89-4738-b5f4-28a984bf5866
Wilkinson, J.S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Melvin, T.
fd87f5eb-2bb9-48fa-b7be-7100ace9c50f
Yin, H.B., Brown, T., Greef, R., Wilkinson, J.S. and Melvin, T.
(2004)
Chemical modification and micropatterning of Si(100) with oligonucleotides.
Microelectronic Engineering, 73-73, .
(doi:10.1016/j.mee.2004.03.060).
Abstract
A method for the reliable attachment. of oligonucleotides to silicon (10 0) surfaces in patterns is described. LTV light exposure of silicon (10 0) coated with alkenes functionalized with carboxylic acid groups and derivatives results in covalent attachment to the silicon surface. The carboxyl-terminated (and derivatives) surfaces act as a substrate for the chemistry of the subsequent attachment of oligonucleotides. Illustrated are our results gained for optimisation of the surface attachment chemistry and the characterisation of the surface with scanning electron microscopy, epifluorescence microscopy and ellipsometry.
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Published date: 1 June 2004
Keywords:
silicon functionalisation, oligonucleotide, conjugation, surfaceattachment chemistryself-assembled monolayers, alkyl monolayers, surfaces, silicon, 1-alkenes, proteins, cells, gold
Identifiers
Local EPrints ID: 20345
URI: http://eprints.soton.ac.uk/id/eprint/20345
ISSN: 0167-9317
PURE UUID: bd33686a-36ab-4840-a809-1860675273c0
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Date deposited: 16 Feb 2006
Last modified: 16 Mar 2024 02:33
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Contributors
Author:
H.B. Yin
Author:
R. Greef
Author:
T. Melvin
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