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Chemical modification and micropatterning of Si(100) with oligonucleotides

Chemical modification and micropatterning of Si(100) with oligonucleotides
Chemical modification and micropatterning of Si(100) with oligonucleotides
A method for the reliable attachment. of oligonucleotides to silicon (10 0) surfaces in patterns is described. LTV light exposure of silicon (10 0) coated with alkenes functionalized with carboxylic acid groups and derivatives results in covalent attachment to the silicon surface. The carboxyl-terminated (and derivatives) surfaces act as a substrate for the chemistry of the subsequent attachment of oligonucleotides. Illustrated are our results gained for optimisation of the surface attachment chemistry and the characterisation of the surface with scanning electron microscopy, epifluorescence microscopy and ellipsometry.
silicon functionalisation, oligonucleotide, conjugation, surface attachment chemistryself-assembled monolayers, alkyl monolayers, surfaces, silicon, 1-alkenes, proteins, cells, gold
0167-9317
830-836
Yin, H.B.
80f33a1f-d886-4f09-adab-bc65e9125c29
Brown, T.
a64aae36-bb30-42df-88a2-11be394e8c89
Greef, R.
91063544-ed89-4738-b5f4-28a984bf5866
Wilkinson, J.S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Melvin, T.
fd87f5eb-2bb9-48fa-b7be-7100ace9c50f
Yin, H.B.
80f33a1f-d886-4f09-adab-bc65e9125c29
Brown, T.
a64aae36-bb30-42df-88a2-11be394e8c89
Greef, R.
91063544-ed89-4738-b5f4-28a984bf5866
Wilkinson, J.S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Melvin, T.
fd87f5eb-2bb9-48fa-b7be-7100ace9c50f

Yin, H.B., Brown, T., Greef, R., Wilkinson, J.S. and Melvin, T. (2004) Chemical modification and micropatterning of Si(100) with oligonucleotides. Microelectronic Engineering, 73-73, 830-836. (doi:10.1016/j.mee.2004.03.060).

Record type: Article

Abstract

A method for the reliable attachment. of oligonucleotides to silicon (10 0) surfaces in patterns is described. LTV light exposure of silicon (10 0) coated with alkenes functionalized with carboxylic acid groups and derivatives results in covalent attachment to the silicon surface. The carboxyl-terminated (and derivatives) surfaces act as a substrate for the chemistry of the subsequent attachment of oligonucleotides. Illustrated are our results gained for optimisation of the surface attachment chemistry and the characterisation of the surface with scanning electron microscopy, epifluorescence microscopy and ellipsometry.

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More information

Published date: 1 June 2004
Keywords: silicon functionalisation, oligonucleotide, conjugation, surface attachment chemistryself-assembled monolayers, alkyl monolayers, surfaces, silicon, 1-alkenes, proteins, cells, gold

Identifiers

Local EPrints ID: 20345
URI: http://eprints.soton.ac.uk/id/eprint/20345
ISSN: 0167-9317
PURE UUID: bd33686a-36ab-4840-a809-1860675273c0
ORCID for J.S. Wilkinson: ORCID iD orcid.org/0000-0003-4712-1697

Catalogue record

Date deposited: 16 Feb 2006
Last modified: 07 Oct 2020 02:11

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