Chemical modification and micropatterning of Si(100) with oligonucleotides

Yin, H.B., Brown, T., Greef, R., Wilkinson, J.S. and Melvin, T. (2004) Chemical modification and micropatterning of Si(100) with oligonucleotides Microelectronic Engineering, 73-73, pp. 830-836. (doi:10.1016/j.mee.2004.03.060).


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A method for the reliable attachment. of oligonucleotides to silicon (10 0) surfaces in patterns is described. LTV light exposure of silicon (10 0) coated with alkenes functionalized with carboxylic acid groups and derivatives results in covalent attachment to the silicon surface. The carboxyl-terminated (and derivatives) surfaces act as a substrate for the chemistry of the subsequent attachment of oligonucleotides. Illustrated are our results gained for optimisation of the surface attachment chemistry and the characterisation of the surface with scanning electron microscopy, epifluorescence microscopy and ellipsometry.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.mee.2004.03.060
ISSNs: 0167-9317 (print)
Related URLs:
Keywords: silicon functionalisation, oligonucleotide, conjugation, surface attachment chemistryself-assembled monolayers, alkyl monolayers, surfaces, silicon, 1-alkenes, proteins, cells, gold

ePrint ID: 20345
Date :
Date Event
1 June 2004Published
Date Deposited: 16 Feb 2006
Last Modified: 16 Apr 2017 22:59
Further Information:Google Scholar

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