Yin, H.B., Brown, T., Greef, R., Wilkinson, J.S. and Melvin, T.
Chemical modification and micropatterning of Si(100) with oligonucleotides
Microelectronic Engineering, 73-73, . (doi:10.1016/j.mee.2004.03.060).
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A method for the reliable attachment. of oligonucleotides to silicon (10 0) surfaces in patterns is described. LTV light exposure of silicon (10 0) coated with alkenes functionalized with carboxylic acid groups and derivatives results in covalent attachment to the silicon surface. The carboxyl-terminated (and derivatives) surfaces act as a substrate for the chemistry of the subsequent attachment of oligonucleotides. Illustrated are our results gained for optimisation of the surface attachment chemistry and the characterisation of the surface with scanning electron microscopy, epifluorescence microscopy and ellipsometry.
|Digital Object Identifier (DOI):
||silicon functionalisation, oligonucleotide, conjugation, surface
attachment chemistryself-assembled monolayers, alkyl monolayers, surfaces, silicon, 1-alkenes, proteins, cells, gold
|1 June 2004||Published|
||16 Feb 2006
||16 Apr 2017 22:59
|Further Information:||Google Scholar|
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