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Chemical modification and micropatterning of Si(100) with oligonucleotides

Yin, H.B., Brown, T., Greef, R., Wilkinson, J.S. and Melvin, T. (2004) Chemical modification and micropatterning of Si(100) with oligonucleotides Microelectronic Engineering, 73-73, pp. 830-836. (doi:10.1016/j.mee.2004.03.060).

Record type: Article


A method for the reliable attachment. of oligonucleotides to silicon (10 0) surfaces in patterns is described. LTV light exposure of silicon (10 0) coated with alkenes functionalized with carboxylic acid groups and derivatives results in covalent attachment to the silicon surface. The carboxyl-terminated (and derivatives) surfaces act as a substrate for the chemistry of the subsequent attachment of oligonucleotides. Illustrated are our results gained for optimisation of the surface attachment chemistry and the characterisation of the surface with scanning electron microscopy, epifluorescence microscopy and ellipsometry.

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Published date: 1 June 2004
Keywords: silicon functionalisation, oligonucleotide, conjugation, surface attachment chemistryself-assembled monolayers, alkyl monolayers, surfaces, silicon, 1-alkenes, proteins, cells, gold


Local EPrints ID: 20345
ISSN: 0167-9317
PURE UUID: bd33686a-36ab-4840-a809-1860675273c0
ORCID for J.S. Wilkinson: ORCID iD

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Date deposited: 16 Feb 2006
Last modified: 17 Jul 2017 16:29

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Author: H.B. Yin
Author: T. Brown
Author: R. Greef
Author: J.S. Wilkinson ORCID iD
Author: T. Melvin

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