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Interactions of human endothelial cells with gold nanoparticles of different morphologies

Interactions of human endothelial cells with gold nanoparticles of different morphologies
Interactions of human endothelial cells with gold nanoparticles of different morphologies
The interactions between noncancerous, primary endothelial cells and gold nanoparticles with different morphologies but the same ligand capping are investigated. The endothelial cells are incubated with gold nanospheres, nanorods, hollow gold spheres, and core/shell silica/gold nanocrystals, which are coated with monocarboxy (1-mercaptoundec-11-yl) hexaethylene glycol (OEG). Cell viability studies show that all types of gold particles are noncytotoxic. The number of particles taken up by the cells is estimated using inductively coupled plasma (ICP), and are found to differ depending on particle morphology. The above results are discussed with respect to heating efficiency. Using experimental data reported earlier and theoretical model calculations which take into account the physical properties and distribution of particles in the cellular microenvironment, it is found that collective heating effects of several cells loaded with nanoparticles must be included to explain the observed viability of the endothelial cells.
gold nanoparticles, laser treatments, endothelial, cellular uptake, cytotoxicity
1613-6810
122-130
Bartczak, Dorota
4d706d11-ee17-4e30-9ba8-1d4b3d878f71
Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Nitti, Simone
aee69803-b6d1-4bf9-9f7f-84955333cd8d
Millar, Timothy M.
ec88510c-ad88-49f6-8b2d-4277c84c1958
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7
Bartczak, Dorota
4d706d11-ee17-4e30-9ba8-1d4b3d878f71
Muskens, Otto L.
2284101a-f9ef-4d79-8951-a6cda5bfc7f9
Nitti, Simone
aee69803-b6d1-4bf9-9f7f-84955333cd8d
Millar, Timothy M.
ec88510c-ad88-49f6-8b2d-4277c84c1958
Kanaras, Antonios G.
667ecfdc-7647-4bd8-be03-a47bf32504c7

Bartczak, Dorota, Muskens, Otto L., Nitti, Simone, Millar, Timothy M. and Kanaras, Antonios G. (2012) Interactions of human endothelial cells with gold nanoparticles of different morphologies. Small, 8 (1), 122-130. (doi:10.1002/smll.201101422). (PMID:22102541)

Record type: Article

Abstract

The interactions between noncancerous, primary endothelial cells and gold nanoparticles with different morphologies but the same ligand capping are investigated. The endothelial cells are incubated with gold nanospheres, nanorods, hollow gold spheres, and core/shell silica/gold nanocrystals, which are coated with monocarboxy (1-mercaptoundec-11-yl) hexaethylene glycol (OEG). Cell viability studies show that all types of gold particles are noncytotoxic. The number of particles taken up by the cells is estimated using inductively coupled plasma (ICP), and are found to differ depending on particle morphology. The above results are discussed with respect to heating efficiency. Using experimental data reported earlier and theoretical model calculations which take into account the physical properties and distribution of particles in the cellular microenvironment, it is found that collective heating effects of several cells loaded with nanoparticles must be included to explain the observed viability of the endothelial cells.

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More information

e-pub ahead of print date: 18 November 2011
Published date: January 2012
Keywords: gold nanoparticles, laser treatments, endothelial, cellular uptake, cytotoxicity
Organisations: Clinical & Experimental Sciences

Identifiers

Local EPrints ID: 203841
URI: https://eprints.soton.ac.uk/id/eprint/203841
ISSN: 1613-6810
PURE UUID: 642cef69-e1bc-4761-9d30-b3a6b90584f4
ORCID for Otto L. Muskens: ORCID iD orcid.org/0000-0003-0693-5504
ORCID for Timothy M. Millar: ORCID iD orcid.org/0000-0002-4539-2445
ORCID for Antonios G. Kanaras: ORCID iD orcid.org/0000-0002-9847-6706

Catalogue record

Date deposited: 22 Nov 2011 10:21
Last modified: 19 Nov 2019 01:45

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Contributors

Author: Dorota Bartczak
Author: Otto L. Muskens ORCID iD
Author: Simone Nitti

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