Favorable outcome of allogeneic hematopoietic cell transplantation for 8p11 myeloproliferative syndrome associated with BCR-FGFR1 gene fusion

Dolan, Michelle, Cioc, Adina, Cross, Nicholas C. P., Neglia, Joseph P. and Tolar, Jakub (2012) Favorable outcome of allogeneic hematopoietic cell transplantation for 8p11 myeloproliferative syndrome associated with BCR-FGFR1 gene fusion. Pediatric Blood and Cancer, 59 (1), 194-196. (doi:10.1002/pbc.23404). (PMID:22106025)

Abstract

We report the case of a child who presented with nonspecific
symptoms suggestive of a rheumatologic disorder, whose bone
marrow had a complex translocation involving the FGFR1 locus.
Hematopathologic findings were subtle and did not definitively
indicate malignancy. Because he responded poorly to initial treatment
with hydroxyurea, and in light of the progressive clinical
course associated with the 8p11 myeloproliferative syndrome, he
underwent an unrelated-donor hematopoietic stem cell transplant.
This patient’s atypical presentation highlights the importance of
obtaining cytogenetic analysis at the time of bone marrow sampling
and considering this uncommon entity in the differential diagnosis
of hematologic disorders.

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Contributors

Author: Nicholas C. P. Cross

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