The University of Southampton
University of Southampton Institutional Repository

The effect of introducing an in-theatre intra-operative specimen radiography (IOSR) system on the management of palpable breast cancer within a single unit

Layfield, D. M, May, D. J., Cutress, R. I., Richardson, C., Agrawal, A., Wise, M and Yiangou, C. (2011) The effect of introducing an in-theatre intra-operative specimen radiography (IOSR) system on the management of palpable breast cancer within a single unit The Breast (doi:10.1016/j.breast.2011.10.010). (PMID:22119488).

Record type: Article

Abstract

Introduction: Intra-operative specimen radiography (IOSR) is used to screen specimens during breastconserving
surgery and attempt to identify incompletely excised lesions. Universal use of IOSR during
surgery for impalpable breast cancer is advocated by current guidelines. This study evaluates the role of
IOSR during breast-conserving surgery for palpable breast cancer.
Methods: Two cohorts of patients who underwent wide local excision for palpable breast cancer were
identified. Retrospective analysis of histological margins, intra-operative cavity shaves, secondary reexcision
rates and specimen weight was completed comparing performance prior to the introduction
of IOSR (October 2003eApril 2005) with that since its introduction (April 2006eOctober 2007).
Results: 224 Patients were included, 111 in the pre-IOSR cohort (PF) and 113 in the IOSR cohort (F). Patient
demographics, tumour size and histology were comparable. No difference in margin involvement prior to
intra-operative cavity shaving was noted, PFe26, Fe31 (p ¼ 0.60). Intra-operative cavity shaves were
carried out more frequently in the IOSR group, PFe9, Fe32 (p ¼ 0.001). When compared with histological
findings, IOSR identified margin compromise with sensitivity¼ 58.1%, specificity ¼ 80.8%, positivepredictive
value ¼ 56.25% and negative predictive value ¼ 81.9%. Re-operation ratewas similar between the
2 groups, PFe26, Fe31 (p ¼ 0.65). Significantly less tissue was excised following use of IOSR; PFe110 g,
Fe70 g (p ¼ 0.001).
Conclusion: Introduction of IOSR significantly reduced specimen weights without increasing re-excision
rates. As volume of breast tissue removed is the most significant determinant of cosmetic outcome
following breast-conserving surgery, the use of IOSR should be advocated in the surgical management of
palpable breast cancer.

Full text not available from this repository.

More information

e-pub ahead of print date: 25 November 2011
Keywords: breast, cancer, intra-operative specimen radiography, treatment, surgery
Organisations: Cancer Sciences

Identifiers

Local EPrints ID: 204805
URI: http://eprints.soton.ac.uk/id/eprint/204805
ISSN: 0960-9776
PURE UUID: 8f335c35-2488-4b55-a66f-4887bad66cc7

Catalogue record

Date deposited: 30 Nov 2011 10:44
Last modified: 18 Jul 2017 11:05

Export record

Altmetrics

Contributors

Author: D. M Layfield
Author: D. J. May
Author: R. I. Cutress
Author: C. Richardson
Author: A. Agrawal
Author: M Wise
Author: C. Yiangou

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×