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Evolution of chlamydia trachomatis

Clarke, I.N. (2011) Evolution of chlamydia trachomatis In, Nahmias, Andre, Danielsson, Dan and Beckman Nahmais, Susa (eds.) The Evolution of Infectious Agents in Relation to Sex. Chichester, GB, Wiley E11-E18. (Annals of the New York Academy of Sciences, 1, 1230). (doi:10.1111/j.1749-6632.2011.06194.x).

Record type: Book Section

Abstract

We know surprisingly little about the evolutionary origins of Chlamydia trachomatis. It causes both ocular (trachoma) and sexually transmitted infections in humans, it is an obligate intracellular pathogen, and there are only a few “isolates” that have been well characterized. From the first few genomes analyzed, it seems that the C. trachomatis genome is highly conserved. The genomes possess high synteny and, in some cases, the sequence variation between genomes is as little as 20 SNPs. Recent indications from partial genome analyses suggest that recombination is the mechanism for generating diversity. There is no accurate molecular clock by which to measure the evolution of C. trachomatis. The origins of both sexually transmitted and ocular C. trachomatis are unclear, but it seems likely that they evolved with humans and shared a common ancestor with environmental chlamydiae some 700 million years ago. Subsequently, evolution within mammalian cells has been accompanied by radical reduction in the C. trachomatis genome

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Published date: August 2011
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 204899
URI: http://eprints.soton.ac.uk/id/eprint/204899
ISBN: 978-1-57331-819-8
PURE UUID: d0555360-0d9e-4064-a2ff-95ee687bb393
ORCID for I.N. Clarke: ORCID iD orcid.org/0000-0002-4938-1620

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Date deposited: 02 Dec 2011 15:03
Last modified: 18 Jul 2017 11:05

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Contributors

Author: I.N. Clarke ORCID iD
Editor: Andre Nahmias
Editor: Dan Danielsson
Editor: Susa Beckman Nahmais

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