The University of Southampton
University of Southampton Institutional Repository

Evolution of chlamydia trachomatis

Clarke, I.N. (2011) Evolution of chlamydia trachomatis In, Nahmias, Andre, Danielsson, Dan and Beckman Nahmais, Susa (eds.) The Evolution of Infectious Agents in Relation to Sex. Chichester, GB, Wiley E11-E18. (Annals of the New York Academy of Sciences, 1, 1230). (doi:10.1111/j.1749-6632.2011.06194.x).

Record type: Book Section


We know surprisingly little about the evolutionary origins of Chlamydia trachomatis. It causes both ocular (trachoma) and sexually transmitted infections in humans, it is an obligate intracellular pathogen, and there are only a few “isolates” that have been well characterized. From the first few genomes analyzed, it seems that the C. trachomatis genome is highly conserved. The genomes possess high synteny and, in some cases, the sequence variation between genomes is as little as 20 SNPs. Recent indications from partial genome analyses suggest that recombination is the mechanism for generating diversity. There is no accurate molecular clock by which to measure the evolution of C. trachomatis. The origins of both sexually transmitted and ocular C. trachomatis are unclear, but it seems likely that they evolved with humans and shared a common ancestor with environmental chlamydiae some 700 million years ago. Subsequently, evolution within mammalian cells has been accompanied by radical reduction in the C. trachomatis genome

Full text not available from this repository.

More information

Published date: August 2011
Organisations: Faculty of Medicine


Local EPrints ID: 204899
ISBN: 978-1-57331-819-8
PURE UUID: d0555360-0d9e-4064-a2ff-95ee687bb393
ORCID for I.N. Clarke: ORCID iD

Catalogue record

Date deposited: 02 Dec 2011 15:03
Last modified: 18 Jul 2017 11:05

Export record



Author: I.N. Clarke ORCID iD
Editor: Andre Nahmias
Editor: Dan Danielsson
Editor: Susa Beckman Nahmais

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.