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Divergent synthetic approach to 6??-modified ?-GalCer analogues

Divergent synthetic approach to 6??-modified ?-GalCer analogues
Divergent synthetic approach to 6??-modified ?-GalCer analogues
A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6??-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6??-modified KRN7000 analogues
1477-0520
8413-8421
Pauwels, Nora
aa5e3e8f-6c86-435e-ba3a-e06235ab0b43
Aspeslagh, Sandrine
7bfd6603-8c2a-435a-b9b9-ce5b8e071621
Vanhoenacker, Gerd
e2b1b1ad-4985-4017-ad0f-e5706408285a
Sandra, Koen
dd635e7f-67c1-41b4-bc71-3c36e984512c
Yu, Esther D.
645d8a79-27b5-4cd7-b34c-2226883e2f15
Zajonc, Dirk M.
47798551-44dd-4b1f-ba3d-f0b3d40f3b86
Elewaut, Dirk
98c0d9e0-e559-4f19-8a56-573fee3da83e
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Van Calenbergh, Serge
9587a6e2-b48b-4f79-807d-b889c7a1d9d6
Pauwels, Nora
aa5e3e8f-6c86-435e-ba3a-e06235ab0b43
Aspeslagh, Sandrine
7bfd6603-8c2a-435a-b9b9-ce5b8e071621
Vanhoenacker, Gerd
e2b1b1ad-4985-4017-ad0f-e5706408285a
Sandra, Koen
dd635e7f-67c1-41b4-bc71-3c36e984512c
Yu, Esther D.
645d8a79-27b5-4cd7-b34c-2226883e2f15
Zajonc, Dirk M.
47798551-44dd-4b1f-ba3d-f0b3d40f3b86
Elewaut, Dirk
98c0d9e0-e559-4f19-8a56-573fee3da83e
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Van Calenbergh, Serge
9587a6e2-b48b-4f79-807d-b889c7a1d9d6

Pauwels, Nora, Aspeslagh, Sandrine, Vanhoenacker, Gerd, Sandra, Koen, Yu, Esther D., Zajonc, Dirk M., Elewaut, Dirk, Linclau, Bruno and Van Calenbergh, Serge (2011) Divergent synthetic approach to 6??-modified ?-GalCer analogues. Organic & Biomolecular Chemistry, 9 (24), 8413-8421. (doi:10.1039/c1ob06235b).

Record type: Article

Abstract

A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6??-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6??-modified KRN7000 analogues

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e-pub ahead of print date: 2 September 2011
Published date: September 2011
Organisations: Chemistry

Identifiers

Local EPrints ID: 205381
URI: http://eprints.soton.ac.uk/id/eprint/205381
ISSN: 1477-0520
PURE UUID: f7252ae5-19dd-4282-acbd-e123f668c9a5
ORCID for Bruno Linclau: ORCID iD orcid.org/0000-0001-8762-0170

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Date deposited: 07 Dec 2011 09:08
Last modified: 18 Feb 2021 16:55

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Contributors

Author: Nora Pauwels
Author: Sandrine Aspeslagh
Author: Gerd Vanhoenacker
Author: Koen Sandra
Author: Esther D. Yu
Author: Dirk M. Zajonc
Author: Dirk Elewaut
Author: Bruno Linclau ORCID iD
Author: Serge Van Calenbergh

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