Divergent synthetic approach to 6??-modified ?-GalCer analogues
Divergent synthetic approach to 6??-modified ?-GalCer analogues
A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6??-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6??-modified KRN7000 analogues
8413-8421
Pauwels, Nora
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Aspeslagh, Sandrine
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Vanhoenacker, Gerd
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Sandra, Koen
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Yu, Esther D.
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Zajonc, Dirk M.
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Elewaut, Dirk
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Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Van Calenbergh, Serge
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September 2011
Pauwels, Nora
aa5e3e8f-6c86-435e-ba3a-e06235ab0b43
Aspeslagh, Sandrine
7bfd6603-8c2a-435a-b9b9-ce5b8e071621
Vanhoenacker, Gerd
e2b1b1ad-4985-4017-ad0f-e5706408285a
Sandra, Koen
dd635e7f-67c1-41b4-bc71-3c36e984512c
Yu, Esther D.
645d8a79-27b5-4cd7-b34c-2226883e2f15
Zajonc, Dirk M.
47798551-44dd-4b1f-ba3d-f0b3d40f3b86
Elewaut, Dirk
98c0d9e0-e559-4f19-8a56-573fee3da83e
Linclau, Bruno
19b9cacd-b8e8-4c65-af36-6352cade84ba
Van Calenbergh, Serge
9587a6e2-b48b-4f79-807d-b889c7a1d9d6
Pauwels, Nora, Aspeslagh, Sandrine, Vanhoenacker, Gerd, Sandra, Koen, Yu, Esther D., Zajonc, Dirk M., Elewaut, Dirk, Linclau, Bruno and Van Calenbergh, Serge
(2011)
Divergent synthetic approach to 6??-modified ?-GalCer analogues.
Organic & Biomolecular Chemistry, 9 (24), .
(doi:10.1039/c1ob06235b).
Abstract
A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6??-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6??-modified KRN7000 analogues
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e-pub ahead of print date: 2 September 2011
Published date: September 2011
Organisations:
Chemistry
Identifiers
Local EPrints ID: 205381
URI: http://eprints.soton.ac.uk/id/eprint/205381
ISSN: 1477-0520
PURE UUID: f7252ae5-19dd-4282-acbd-e123f668c9a5
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Date deposited: 07 Dec 2011 09:08
Last modified: 15 Mar 2024 03:05
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Contributors
Author:
Nora Pauwels
Author:
Sandrine Aspeslagh
Author:
Gerd Vanhoenacker
Author:
Koen Sandra
Author:
Esther D. Yu
Author:
Dirk M. Zajonc
Author:
Dirk Elewaut
Author:
Serge Van Calenbergh
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