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Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve

Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve
Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve
Polymersomes are nano-sized vesicles formed from amphiphilic block copolymers that have been identified as potential drug delivery vehicles to the inner ear. The aim of this study is to provide targeting to specific cells within the inner ear by functionalizing the polymersome surface with Tet1 peptide sequence. Tet1 peptide specifically binds to the GT1b receptor on neurons and is expected to target the polymersomes towards the cochlear nerve. The Tet1 functionalized PEG-b-PCL PMs were administered using routine drug delivery routes: transtympanic injection and cochleostomy. Delivery via cochleostomy of Tet1 functionalized polymersomes resulted in cochlear nerve targeting; in contrast this was not seen after transtympanic injection.
1176-9114
Zhang, Ya
1820fb16-8a49-4749-9964-12bcbded2641
Zhang, Weikai
d742f246-a5f8-4b4f-b249-7676d4769fa7
Johnston, Alexander H.
b3325b84-67c4-4d9c-ba97-57f2fdf017ba
Newman, Tracey .A.
322290cb-2e9c-445d-a047-00b1bea39a25
Pyykko, Ilmari
4eedf122-1a40-466d-b69d-9b183958c7fc
Zou, Jing
00c594ea-0fc7-447c-88af-014ee31f1454
Zhang, Ya
1820fb16-8a49-4749-9964-12bcbded2641
Zhang, Weikai
d742f246-a5f8-4b4f-b249-7676d4769fa7
Johnston, Alexander H.
b3325b84-67c4-4d9c-ba97-57f2fdf017ba
Newman, Tracey .A.
322290cb-2e9c-445d-a047-00b1bea39a25
Pyykko, Ilmari
4eedf122-1a40-466d-b69d-9b183958c7fc
Zou, Jing
00c594ea-0fc7-447c-88af-014ee31f1454

Zhang, Ya, Zhang, Weikai, Johnston, Alexander H., Newman, Tracey .A., Pyykko, Ilmari and Zou, Jing (2012) Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve. International Journal of Nanomedicine. (PMID:22403485)

Record type: Article

Abstract

Polymersomes are nano-sized vesicles formed from amphiphilic block copolymers that have been identified as potential drug delivery vehicles to the inner ear. The aim of this study is to provide targeting to specific cells within the inner ear by functionalizing the polymersome surface with Tet1 peptide sequence. Tet1 peptide specifically binds to the GT1b receptor on neurons and is expected to target the polymersomes towards the cochlear nerve. The Tet1 functionalized PEG-b-PCL PMs were administered using routine drug delivery routes: transtympanic injection and cochleostomy. Delivery via cochleostomy of Tet1 functionalized polymersomes resulted in cochlear nerve targeting; in contrast this was not seen after transtympanic injection.

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More information

Accepted/In Press date: 6 December 2011
Published date: 23 February 2012
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 205415
URI: http://eprints.soton.ac.uk/id/eprint/205415
ISSN: 1176-9114
PURE UUID: cd0ed730-9342-4df2-97f5-7f60268df744
ORCID for Tracey .A. Newman: ORCID iD orcid.org/0000-0002-3727-9258

Catalogue record

Date deposited: 07 Dec 2011 14:51
Last modified: 18 Feb 2021 16:46

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Contributors

Author: Ya Zhang
Author: Weikai Zhang
Author: Alexander H. Johnston
Author: Ilmari Pyykko
Author: Jing Zou

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