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Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve

Record type: Article

Polymersomes are nano-sized vesicles formed from amphiphilic block copolymers that have been identified as potential drug delivery vehicles to the inner ear. The aim of this study is to provide targeting to specific cells within the inner ear by functionalizing the polymersome surface with Tet1 peptide sequence. Tet1 peptide specifically binds to the GT1b receptor on neurons and is expected to target the polymersomes towards the cochlear nerve. The Tet1 functionalized PEG-b-PCL PMs were administered using routine drug delivery routes: transtympanic injection and cochleostomy. Delivery via cochleostomy of Tet1 functionalized polymersomes resulted in cochlear nerve targeting; in contrast this was not seen after transtympanic injection.

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Citation

Zhang, Ya, Zhang, Weikai, Johnston, Alexander H., Newman, Tracey .A., Pyykko, Ilmari and Zou, Jing (2012) Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve International Journal of Nanomedicine (PMID:22403485).

More information

Accepted/In Press date: 6 December 2011
Published date: 23 February 2012
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 205415
URI: http://eprints.soton.ac.uk/id/eprint/205415
ISSN: 1176-9114
PURE UUID: cd0ed730-9342-4df2-97f5-7f60268df744

Catalogue record

Date deposited: 07 Dec 2011 14:51
Last modified: 18 Jul 2017 11:04

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Contributors

Author: Ya Zhang
Author: Weikai Zhang
Author: Alexander H. Johnston
Author: Ilmari Pyykko
Author: Jing Zou

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