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Activation of TrkB receptors by NGF? mimetic peptide conjugated polymersome nanoparticles

Activation of TrkB receptors by NGF? mimetic peptide conjugated polymersome nanoparticles
Activation of TrkB receptors by NGF? mimetic peptide conjugated polymersome nanoparticles
Activation of tyrosine kinase receptor B (TrkB), a neurotrophin receptor, has been shown to increase neuronal cell survival and promote regeneration. Stimulation of the Trkb receptor by neurotrophic growth factors has been identified as a possible therapeutic target for the treatment of neurodegenerative disorders. However, growth factor delivery is problematic due to a short half-life in-vivo. We have conjugated hNgf-EE, a short peptide mimetic of NGF? to the surface of polymersome nanoparticles and shown that they are capable of activating the TrkB receptor in vitro in the SHSY-G7 cell line. We propose that polymersomes could act as a scaffold for the delivery of TrkB activating moieties and that the polymersome size and polyethylene glycol surface have been shown to increase in vivo retention time. These multifunctional nanoparticles have potential for the treatment of neurodegenerative disorders by TrkB activation.
1549-9634
Roy, S.
ac99cb46-0b15-486d-bd52-8a0523d7dc39
Johnston, A.H.
c04f2567-5945-4e08-97df-7834ce234fcd
Moin, S.T.
e9be0ef3-726c-4e75-a716-38e5b8f177e6
Dudas, J.
d8c2fb5c-c0b1-4489-a299-b9c25ecf2c41
Newman, T.A.
322290cb-2e9c-445d-a047-00b1bea39a25
Hausott, B.
b05898c8-4f68-405e-89e7-17f474d092a0
Schrott-Fischer, A.
aa3bbdde-ee13-4dae-ab1f-a4bc5cdda499
Glueckert, R.
0cdb19fc-9821-4631-9189-77aa07843274
Roy, S.
ac99cb46-0b15-486d-bd52-8a0523d7dc39
Johnston, A.H.
c04f2567-5945-4e08-97df-7834ce234fcd
Moin, S.T.
e9be0ef3-726c-4e75-a716-38e5b8f177e6
Dudas, J.
d8c2fb5c-c0b1-4489-a299-b9c25ecf2c41
Newman, T.A.
322290cb-2e9c-445d-a047-00b1bea39a25
Hausott, B.
b05898c8-4f68-405e-89e7-17f474d092a0
Schrott-Fischer, A.
aa3bbdde-ee13-4dae-ab1f-a4bc5cdda499
Glueckert, R.
0cdb19fc-9821-4631-9189-77aa07843274

Roy, S., Johnston, A.H., Moin, S.T., Dudas, J., Newman, T.A., Hausott, B., Schrott-Fischer, A. and Glueckert, R. (2012) Activation of TrkB receptors by NGF? mimetic peptide conjugated polymersome nanoparticles. Nanomedicine Nanotechnology Biology and Medicine. (PMID:22206946)

Record type: Article

Abstract

Activation of tyrosine kinase receptor B (TrkB), a neurotrophin receptor, has been shown to increase neuronal cell survival and promote regeneration. Stimulation of the Trkb receptor by neurotrophic growth factors has been identified as a possible therapeutic target for the treatment of neurodegenerative disorders. However, growth factor delivery is problematic due to a short half-life in-vivo. We have conjugated hNgf-EE, a short peptide mimetic of NGF? to the surface of polymersome nanoparticles and shown that they are capable of activating the TrkB receptor in vitro in the SHSY-G7 cell line. We propose that polymersomes could act as a scaffold for the delivery of TrkB activating moieties and that the polymersome size and polyethylene glycol surface have been shown to increase in vivo retention time. These multifunctional nanoparticles have potential for the treatment of neurodegenerative disorders by TrkB activation.

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More information

Accepted/In Press date: 20 December 2011
Published date: April 2012
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 206395
URI: http://eprints.soton.ac.uk/id/eprint/206395
ISSN: 1549-9634
PURE UUID: 464054f6-937f-4f01-847b-b08248c79cfb
ORCID for T.A. Newman: ORCID iD orcid.org/0000-0002-3727-9258

Catalogue record

Date deposited: 20 Dec 2011 11:38
Last modified: 18 Feb 2021 16:46

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Contributors

Author: S. Roy
Author: A.H. Johnston
Author: S.T. Moin
Author: J. Dudas
Author: T.A. Newman ORCID iD
Author: B. Hausott
Author: A. Schrott-Fischer
Author: R. Glueckert

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