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Effect of swab type on the analytical sensitivity of five point-of-care tests for group A streptococci

Lasseter, G.M., McNulty, C.A.M. and Hobbs, F.D.R. et al. for the PRImary care Streptococcal Management (PRISM) Investigators Group (2011) Effect of swab type on the analytical sensitivity of five point-of-care tests for group A streptococci British Journal of Biomedical Science, 68, (2), pp. 91-94. (PMID:21706921).

Record type: Article


The majority of point-of-care rapid antigen detection tests (RADTs) for group A b-haemolytic streptococci (GABHS) are sold by manufacturers with kit swabs provided. This is convenient for the purchaser but may have unexpected effects on kit performance. Most clinical validation studies compare the performance of RADTs against culture and in these studies the clinical throat samples are often collected using various swab types; usually swabs provided with bacteriology transport media. It is widely assumed that swab type has no impact on RADT performance, and despite the fact that manufacturers often provide swabs with their kit that have been specifically validated for use with a RADT, many clinical validation studies routinely disregard these recommendations by using a variety of swab types.

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Published date: 2011
Keywords: humans, pharyngitis, point-of-care systems, reagent kits, diagnostic, sensitivity and specificity, specimen handling, streptococcal infections, streptococcus pyogenes
Organisations: Primary Care & Population Sciences


Local EPrints ID: 206467
ISSN: 0967-4845
PURE UUID: 4e251b1f-852e-4c82-aea9-268c4fc4617a
ORCID for M Moore: ORCID iD

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Date deposited: 21 Dec 2011 11:18
Last modified: 18 Jul 2017 10:51

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Author: G.M. Lasseter
Author: C.A.M. McNulty
Author: F.D.R. Hobbs
Author: D. Mant
Author: P. Little
Author: J. Barnett
Author: B Delaney
Author: P Glasziou
Author: P Hawtin
Author: J. Kelly
Author: G.M. Leydon
Author: R McManus
Author: M Moore ORCID iD
Author: M. Mullee
Author: J. Raftery
Author: R. Salter
Author: S. Smith
Author: T. Thomas
Author: A. Tuck
Author: I. Williamson
Author: L. Wright

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