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CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides

Gerrard, Simon R., Edrees, Mastoura M., Bouamaied, Imenne, Fox, Keith R. and Brown, Tom (2010) CG base pair recognition within DNA triple helices by modified N-methylpyrrolo-dC nucleosides Organic & Biomolecular Chemistry, 8, (22), pp. 5087-5096. (doi:10.1039/c0ob00119h). (PMID:20835452).

Record type: Article

Abstract

3-Aminophenyl-modified analogues of the bicyclic nucleoside N-methyl-3H-pyrrolo[2,3-d]pyrimidin-2(7H)-one were synthesised and incorporated directly into triplex-forming oligonucleotides in order to utilise their extended hydrogen bonding motif for recognition of the CG base pair. All analogues demonstrated strong binding affinity and very good selectivity for CG from pH 6.2 to 7.0; a marked improvement on previous modifications.



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Published date: 6 September 2010
Organisations: Molecular and Cellular

Identifiers

Local EPrints ID: 206541
URI: http://eprints.soton.ac.uk/id/eprint/206541
ISSN: 1477-0520
PURE UUID: 6846c81f-8606-4f75-84cf-7821867549c6
ORCID for Keith R. Fox: ORCID iD orcid.org/0000-0002-2925-7315

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Date deposited: 22 Dec 2011 15:29
Last modified: 18 Jul 2017 10:51

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Contributors

Author: Mastoura M. Edrees
Author: Imenne Bouamaied
Author: Keith R. Fox ORCID iD
Author: Tom Brown

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