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Voltammetry and determination of metronidazole at a carbon fiber microdisk electrode

Voltammetry and determination of metronidazole at a carbon fiber microdisk electrode
Voltammetry and determination of metronidazole at a carbon fiber microdisk electrode
The electrochemistry of metronidazole, 1-(hydroxyethyl)-2-methyl-5-nitroimidazole, was investigated at a carbon fiber microdisk electrode in pH 9 Britton Robinson buffer. Under these conditions, the reduction of metronidazole is controlled by both mass transport to the microdisk and adsorption with an equilibrium constant of 4 x 10(3) mol(-1) dm(3) and a saturation coverage of 0.88 x 10(-8) mol cm(-2). The adsorption and accumulation of metronidazole on the surface of the carbon fiber allows its determination at low concentrations by square wave adsorptive stripping voltammetry. A detection limit for metronidazole of 5 x 10(-7) mol dm(-3) and a R.S.D. of 3.7 % at 1 x 10(-6) mol dm(-3) (n = 4) were obtained with a two electrode system with no stirring during the accumulation step. Based on this method, a simple procedure for the determination of metronidazole in urine is described which requires no pre-treatment of the sample before analysis.
metronidazole, carbon fiber microdisk, stripping voltammetry anodic-stripping voltammetry, performance liquid-chromatography, pharmaceutical dosage forms, aqueous alkaline-solution, electrochemicalreduction, nitroimidazole drugs, selective toxicity, gold electrode, human serum, microelectrode
0039-9140
869-874
Bartlett, P.N.
d99446db-a59d-4f89-96eb-f64b5d8bb075
Ghoneim, E.
815cf10f-3afa-42e5-9b31-666480a484b2
El-Hefnawy, G.
50a5ca3a-a0d3-4f96-8a38-5f6fa1b10c77
El-Hallag, I.
e14160d5-e6af-4f31-aa2a-cc194adc1412
Bartlett, P.N.
d99446db-a59d-4f89-96eb-f64b5d8bb075
Ghoneim, E.
815cf10f-3afa-42e5-9b31-666480a484b2
El-Hefnawy, G.
50a5ca3a-a0d3-4f96-8a38-5f6fa1b10c77
El-Hallag, I.
e14160d5-e6af-4f31-aa2a-cc194adc1412

Bartlett, P.N., Ghoneim, E., El-Hefnawy, G. and El-Hallag, I. (2005) Voltammetry and determination of metronidazole at a carbon fiber microdisk electrode. Talanta, 66 (4), 869-874. (doi:10.1016/j.talanta.2004.12.048).

Record type: Article

Abstract

The electrochemistry of metronidazole, 1-(hydroxyethyl)-2-methyl-5-nitroimidazole, was investigated at a carbon fiber microdisk electrode in pH 9 Britton Robinson buffer. Under these conditions, the reduction of metronidazole is controlled by both mass transport to the microdisk and adsorption with an equilibrium constant of 4 x 10(3) mol(-1) dm(3) and a saturation coverage of 0.88 x 10(-8) mol cm(-2). The adsorption and accumulation of metronidazole on the surface of the carbon fiber allows its determination at low concentrations by square wave adsorptive stripping voltammetry. A detection limit for metronidazole of 5 x 10(-7) mol dm(-3) and a R.S.D. of 3.7 % at 1 x 10(-6) mol dm(-3) (n = 4) were obtained with a two electrode system with no stirring during the accumulation step. Based on this method, a simple procedure for the determination of metronidazole in urine is described which requires no pre-treatment of the sample before analysis.

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More information

Published date: 15 May 2005
Keywords: metronidazole, carbon fiber microdisk, stripping voltammetry anodic-stripping voltammetry, performance liquid-chromatography, pharmaceutical dosage forms, aqueous alkaline-solution, electrochemicalreduction, nitroimidazole drugs, selective toxicity, gold electrode, human serum, microelectrode

Identifiers

Local EPrints ID: 20710
URI: http://eprints.soton.ac.uk/id/eprint/20710
ISSN: 0039-9140
PURE UUID: 7f6249e2-beac-4f8e-b031-a8a949eadb33
ORCID for P.N. Bartlett: ORCID iD orcid.org/0000-0002-7300-6900

Catalogue record

Date deposited: 28 Feb 2006
Last modified: 08 Oct 2019 00:55

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