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Multifunctional redox catalysts as selective enhancers of oxidative stress

Multifunctional redox catalysts as selective enhancers of oxidative stress
Multifunctional redox catalysts as selective enhancers of oxidative stress
Certain cancer cells proliferate under conditions of oxidative stress (OS) and might therefore be selectively targeted by redox catalysts. Among these catalysts, compounds containing a chalcogen and a quinone redox centre are particularly well suited to respond to the presence of OS. These catalysts combine the specific electrochemical features of quinones and chalcogens. They exhibit high selectivity and efficiency against oxidatively stressed rat PC12, human Jurkat and human Daudi cells in cell culture, where their mode of action most likely involves the catalytic activation of existent and the generation of new reactive oxygen species. The high efficiency and selectivity shown by these catalysts makes them interesting for the development of anti-cancer drugs.
superoxide-dismutase, glutathione content, enzyme levels, free-radicals, pc12 cells, in-vitro, antioxidant, selenium, culture, cancer
1477-0520
2579-2587
Fry, Fiona H.
5437ab6b-9b39-4332-ab49-76d851b8d61e
Holme, Andrea L.
361cd045-cb1a-4d59-8328-1a5e14cd482f
Giles, Niroshini M.
76ac536a-4f3a-4370-a0f0-51646006f940
Giles, Gregory I.
0e3c10cd-6d8c-4f95-8fd8-45259415226d
Collins, Catriona
32421b9e-0024-4f72-a2c5-fded98366e74
Holt, Kim
735c3b42-c526-4d52-808e-73cc5ade5338
Pariagh, Sandra
61f3ed25-2a1f-423f-9b69-a0cb42e9944b
Gelbrich, Thomas
42309d69-eaf1-4bb7-ba2e-db61f338e370
Hursthouse, Michael B.
a65b4d35-2ea0-47e7-938a-d744f4d9ba28
Gutowski, Nick J.
01ec4cd7-8e92-4e73-b202-1f2891223e2f
Jacob, Claus
251df526-1185-4598-bb11-a9ee0654f1bb
Fry, Fiona H.
5437ab6b-9b39-4332-ab49-76d851b8d61e
Holme, Andrea L.
361cd045-cb1a-4d59-8328-1a5e14cd482f
Giles, Niroshini M.
76ac536a-4f3a-4370-a0f0-51646006f940
Giles, Gregory I.
0e3c10cd-6d8c-4f95-8fd8-45259415226d
Collins, Catriona
32421b9e-0024-4f72-a2c5-fded98366e74
Holt, Kim
735c3b42-c526-4d52-808e-73cc5ade5338
Pariagh, Sandra
61f3ed25-2a1f-423f-9b69-a0cb42e9944b
Gelbrich, Thomas
42309d69-eaf1-4bb7-ba2e-db61f338e370
Hursthouse, Michael B.
a65b4d35-2ea0-47e7-938a-d744f4d9ba28
Gutowski, Nick J.
01ec4cd7-8e92-4e73-b202-1f2891223e2f
Jacob, Claus
251df526-1185-4598-bb11-a9ee0654f1bb

Fry, Fiona H., Holme, Andrea L., Giles, Niroshini M., Giles, Gregory I., Collins, Catriona, Holt, Kim, Pariagh, Sandra, Gelbrich, Thomas, Hursthouse, Michael B., Gutowski, Nick J. and Jacob, Claus (2005) Multifunctional redox catalysts as selective enhancers of oxidative stress. Organic & Biomolecular Chemistry, 3 (14), 2579-2587. (doi:10.1039/b502197a).

Record type: Article

Abstract

Certain cancer cells proliferate under conditions of oxidative stress (OS) and might therefore be selectively targeted by redox catalysts. Among these catalysts, compounds containing a chalcogen and a quinone redox centre are particularly well suited to respond to the presence of OS. These catalysts combine the specific electrochemical features of quinones and chalcogens. They exhibit high selectivity and efficiency against oxidatively stressed rat PC12, human Jurkat and human Daudi cells in cell culture, where their mode of action most likely involves the catalytic activation of existent and the generation of new reactive oxygen species. The high efficiency and selectivity shown by these catalysts makes them interesting for the development of anti-cancer drugs.

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Published date: 20 May 2005
Keywords: superoxide-dismutase, glutathione content, enzyme levels, free-radicals, pc12 cells, in-vitro, antioxidant, selenium, culture, cancer

Identifiers

Local EPrints ID: 20799
URI: http://eprints.soton.ac.uk/id/eprint/20799
ISSN: 1477-0520
PURE UUID: fa56a852-5a92-4ab6-9365-09727cf5841d

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Date deposited: 01 Mar 2006
Last modified: 15 Jul 2019 19:25

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Contributors

Author: Fiona H. Fry
Author: Andrea L. Holme
Author: Niroshini M. Giles
Author: Gregory I. Giles
Author: Catriona Collins
Author: Kim Holt
Author: Sandra Pariagh
Author: Thomas Gelbrich
Author: Michael B. Hursthouse
Author: Nick J. Gutowski
Author: Claus Jacob

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