Natural products as a hunting ground for combinatorial chemistry
Natural products as a hunting ground for combinatorial chemistry
Natural products have a long history of success as biologically active leads for therapeutic agents. The ability to prepare analogues and to discover structure-activity relationships is necessary to truly harness the potential of natural products. Recently, combinatorial chemistry has risen to this challenge, and even fairly complex natural products can be targeted for parallel synthesis. Academic and industrial efforts have employed natural products from the peptide, alkaloid, polyketide, and terpenoid and steroid classes in combinatorial chemistry approaches for the production of medicinally important compounds.
solid-phase synthesis, biological evaluation, parallel synthesis, libraries, analogs, design, drugs, strategies, molecules, discovery
584-590
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9
1 December 2004
Ganesan, A.
62aa5a87-9308-4383-8686-99726b6bcfb9
Ganesan, A.
(2004)
Natural products as a hunting ground for combinatorial chemistry.
Current Opinion in Biotechnology, 15 (6), .
(doi:10.1016/j.copbio.2004.09.002).
Abstract
Natural products have a long history of success as biologically active leads for therapeutic agents. The ability to prepare analogues and to discover structure-activity relationships is necessary to truly harness the potential of natural products. Recently, combinatorial chemistry has risen to this challenge, and even fairly complex natural products can be targeted for parallel synthesis. Academic and industrial efforts have employed natural products from the peptide, alkaloid, polyketide, and terpenoid and steroid classes in combinatorial chemistry approaches for the production of medicinally important compounds.
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Published date: 1 December 2004
Keywords:
solid-phase synthesis, biological evaluation, parallel synthesis, libraries, analogs, design, drugs, strategies, molecules, discovery
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Local EPrints ID: 20807
URI: http://eprints.soton.ac.uk/id/eprint/20807
ISSN: 0958-1669
PURE UUID: 70f8d46e-b267-4594-9f50-463b8382d7ae
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Date deposited: 28 Feb 2006
Last modified: 15 Mar 2024 06:26
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Author:
A. Ganesan
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