A diversity of SERCA Ca2+ pump inhibitors

Michelangeli, Francesco and East, J.Malcolm (2011) A diversity of SERCA Ca2+ pump inhibitors Biochemical Society Transactions, 39, (3), pp. 789-797. (doi:10.1042/BST0390789). (PMID:21599650).


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The SERCA (sarcoplasmic/endoplasmic reticulum Ca2+-ATPase) is probably the most extensively studied membrane protein transporter. There is a vast array of diverse inhibitors for the Ca2+ pump, and many have proved significant in helping to elucidate both the mechanism of transport and gaining conformational structures. Some SERCA inhibitors such as thapsigargin have been used extensively as pharmacological tools to probe the roles of Ca2+ stores in Ca2+ signalling processes. Furthermore, some inhibitors have been implicated in the cause of diseases associated with endocrine disruption by environmental pollutants, whereas others are being developed as potential anticancer agents. The present review therefore aims to highlight some of the wide range of chemically diverse inhibitors that are known, their mechanisms of action and their binding location on the Ca2+ ATPase. Additionally, some ideas for the future development of more useful isoform-specific inhibitors and anticancer drugs are presented.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1042/BST0390789
ISSNs: 0300-5127 (print)
Related URLs:
Subjects: Q Science > QD Chemistry
Q Science > QH Natural history > QH301 Biology
Organisations: Molecular and Cellular
ePrint ID: 208179
Date :
Date Event
June 2011Published
Date Deposited: 18 Jan 2012 12:31
Last Modified: 18 Apr 2017 00:35
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/208179

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