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A diversity of SERCA Ca2+ pump inhibitors

Michelangeli, Francesco and East, J.Malcolm (2011) A diversity of SERCA Ca2+ pump inhibitors Biochemical Society Transactions, 39, (3), pp. 789-797. (doi:10.1042/BST0390789). (PMID:21599650).

Record type: Article


The SERCA (sarcoplasmic/endoplasmic reticulum Ca2+-ATPase) is probably the most extensively studied membrane protein transporter. There is a vast array of diverse inhibitors for the Ca2+ pump, and many have proved significant in helping to elucidate both the mechanism of transport and gaining conformational structures. Some SERCA inhibitors such as thapsigargin have been used extensively as pharmacological tools to probe the roles of Ca2+ stores in Ca2+ signalling processes. Furthermore, some inhibitors have been implicated in the cause of diseases associated with endocrine disruption by environmental pollutants, whereas others are being developed as potential anticancer agents. The present review therefore aims to highlight some of the wide range of chemically diverse inhibitors that are known, their mechanisms of action and their binding location on the Ca2+ ATPase. Additionally, some ideas for the future development of more useful isoform-specific inhibitors and anticancer drugs are presented.

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Published date: June 2011
Organisations: Molecular and Cellular


Local EPrints ID: 208179
ISSN: 0300-5127
PURE UUID: 26586f3d-3af3-4658-81bd-2e13e1604591

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Date deposited: 18 Jan 2012 12:31
Last modified: 18 Jul 2017 10:49

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Author: Francesco Michelangeli
Author: J.Malcolm East

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