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Intrauterine growth and postnatal skeletal development: findings from the Southampton Women's Survey

Intrauterine growth and postnatal skeletal development: findings from the Southampton Women's Survey
Intrauterine growth and postnatal skeletal development: findings from the Southampton Women's Survey
We have previously demonstrated associations between fetal growth in late pregnancy
and postnatal bone mass. However, the relationships between the intrauterine and
early postnatal skeletal growth trajectory remain unknown. We addressed this in a
large population-based mother–offspring cohort study.A total of 628 mother–offspring
pairs were recruited from the SouthamptonWomen’s Survey. Fetal abdominal circumference
was measured at 11, 19 and 34 weeks gestation using high-resolution ultrasound
with femur length assessed at 19 and 34 weeks. Bone mineral content was
measured postnatally in the offspring using dual-energy X-ray absorptiometry at birth
and 4 years; postnatal linear growth was assessed at birth, 6, 12, 24, 36 and 48 months.
Late pregnancy abdominal circumference growth (19–34 weeks) was strongly (P < 0.01)
related to bone mass at birth, but less robustly associated with bone mass at 4 years.
Early pregnancy growth (11–19 weeks) was more strongly related to bone mass at 4
years than at birth. Postnatal relationships between growth and skeletal indices at 4
years were stronger for the first and second postnatal years, than the period aged 2–4
years. The proportion of children changing their place in the distribution of growth
velocities progressively reduced with each year of postnatal life. The late intrauterine
growth trajectory is a better predictor of skeletal growth and mineralisation at birth,
while the early intrauterine growth trajectory is a more powerful determinant of
skeletal status at age 4 years. The perturbations in this trajectory which influence
childhood bone mass warrant further research.
fetal growth, Southampton Women’s Survey, neonatal bone mineralisation, childhood bone mineralisation, childhood growth
0269-5022
34-44
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Mahon, Pamela A.
5a824126-9030-4e8a-9a0e-dafb8aa280f9
Kim, Miranda
c2e4ad50-0a64-4da9-8335-78531d88e93d
Cole, Zoe A.
6802e58a-59b3-4518-bb7d-6f721732cd61
Robinson, Sian M.
ba591c98-4380-456a-be8a-c452f992b69b
Javaid, Kassim
69bf78c2-9bb1-48b8-8c26-157a823b3421
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Mahon, Pamela A.
5a824126-9030-4e8a-9a0e-dafb8aa280f9
Kim, Miranda
c2e4ad50-0a64-4da9-8335-78531d88e93d
Cole, Zoe A.
6802e58a-59b3-4518-bb7d-6f721732cd61
Robinson, Sian M.
ba591c98-4380-456a-be8a-c452f992b69b
Javaid, Kassim
69bf78c2-9bb1-48b8-8c26-157a823b3421
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6

Harvey, Nicholas C., Mahon, Pamela A., Kim, Miranda, Cole, Zoe A., Robinson, Sian M., Javaid, Kassim, Inskip, Hazel M., Godfrey, Keith M., Dennison, Elaine M. and Cooper, Cyrus (2012) Intrauterine growth and postnatal skeletal development: findings from the Southampton Women's Survey. Paediatric and Perinatal Epidemiology, 26 (1), 34-44. (doi:10.1111/j.1365-3016.2011.01237.x). (PMID:22150706)

Record type: Article

Abstract

We have previously demonstrated associations between fetal growth in late pregnancy
and postnatal bone mass. However, the relationships between the intrauterine and
early postnatal skeletal growth trajectory remain unknown. We addressed this in a
large population-based mother–offspring cohort study.A total of 628 mother–offspring
pairs were recruited from the SouthamptonWomen’s Survey. Fetal abdominal circumference
was measured at 11, 19 and 34 weeks gestation using high-resolution ultrasound
with femur length assessed at 19 and 34 weeks. Bone mineral content was
measured postnatally in the offspring using dual-energy X-ray absorptiometry at birth
and 4 years; postnatal linear growth was assessed at birth, 6, 12, 24, 36 and 48 months.
Late pregnancy abdominal circumference growth (19–34 weeks) was strongly (P < 0.01)
related to bone mass at birth, but less robustly associated with bone mass at 4 years.
Early pregnancy growth (11–19 weeks) was more strongly related to bone mass at 4
years than at birth. Postnatal relationships between growth and skeletal indices at 4
years were stronger for the first and second postnatal years, than the period aged 2–4
years. The proportion of children changing their place in the distribution of growth
velocities progressively reduced with each year of postnatal life. The late intrauterine
growth trajectory is a better predictor of skeletal growth and mineralisation at birth,
while the early intrauterine growth trajectory is a more powerful determinant of
skeletal status at age 4 years. The perturbations in this trajectory which influence
childhood bone mass warrant further research.

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More information

e-pub ahead of print date: 13 December 2011
Published date: January 2012
Keywords: fetal growth, Southampton Women’s Survey, neonatal bone mineralisation, childhood bone mineralisation, childhood growth
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 208343
URI: http://eprints.soton.ac.uk/id/eprint/208343
ISSN: 0269-5022
PURE UUID: 63d73992-2d2b-46b6-943b-3757cb4754fe
ORCID for Nicholas C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for Sian M. Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for Hazel M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for Elaine M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

Catalogue record

Date deposited: 18 Jan 2012 14:32
Last modified: 18 Mar 2024 02:58

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Contributors

Author: Pamela A. Mahon
Author: Miranda Kim
Author: Zoe A. Cole
Author: Sian M. Robinson ORCID iD
Author: Kassim Javaid
Author: Hazel M. Inskip ORCID iD
Author: Cyrus Cooper ORCID iD

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