Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study


Helmersson-Karlqvist, Johanna, Miles, Elizabeth A., Vlachava, Maria, Kremmyda, Lefkothea-Stella, Noakes, Paul S., Diaper, Norma D., Godfrey, Keith M., Calder, Philip C. and Basu, Samar (2011) Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study Prostaglandins, Leukotrienes and Essential Fatty Acids, 86, (1-2), pp. 35-38. (doi:10.1016/j.plefa.2011.10.008). (PMID:22047909).

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Description/Abstract

Oily fish intake during pregnancy may reduce the risk of allergic diseases in infancy possibly by shifts in the fatty acid balance and subsequent altered prostaglandin (PG) formation. This intervention is the first study to evaluate if increased oily fish intake affects in vivo PGF2α formation during pregnancy. British pregnant women were randomised to two portions of farmed salmon weekly (n=47), or maintenance of their normal diet low in fish (n=41), from pregnancy week 20 until parturition. The concentrations of eicosapentaenoic and docosahexaenoic acids in plasma phosphatidylcholine (PC) were higher and the concentration of arachidonic acid in plasma PC was lower in the salmon group than the control group at weeks 34 and 38 of pregnancy. PGF2α formation was evaluated by urinary measurement of 15-keto-dihydro-PGF2α, a major PGF2α metabolite, at 20, 34 and 38 weeks. In both the salmon and control groups urinary 15-keto-dihydro-PGF2α concentrations increased significantly during pregnancy, which may be of physiological importance. Oily fish intervention altered fatty acid concentrations but did not affect urinary 15-keto-dihydro-PGF2α concentrations in pregnant women.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.plefa.2011.10.008
Keywords: prostaglandin F2a, pregnancy, salmon, n-3 long chain polyunsaturated fatty acidsAllergyCOX
Subjects:
Organisations: Faculty of Health Sciences
ePrint ID: 208359
Date :
Date Event
1 November 2011e-pub ahead of print
January 2012Published
Date Deposited: 19 Jan 2012 10:00
Last Modified: 18 Apr 2017 00:33
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/208359

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