The University of Southampton
University of Southampton Institutional Repository

Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study

Helmersson-Karlqvist, Johanna, Miles, Elizabeth A., Vlachava, Maria, Kremmyda, Lefkothea-Stella, Noakes, Paul S., Diaper, Norma D., Godfrey, Keith M., Calder, Philip C. and Basu, Samar (2012) Enhanced prostaglandin F2α formation in human pregnancy and the effect of increased oily fish intake: results from the Salmon in Pregnancy Study Prostaglandins, Leukotrienes and Essential Fatty Acids, 86, (1-2), pp. 35-38. (PMID:22047909).

Record type: Article


Oily fish intake during pregnancy may reduce the risk of allergic diseases in infancy possibly by shifts in the fatty acid balance and subsequent altered prostaglandin (PG) formation. This intervention is the first study to evaluate if increased oily fish intake affects in vivo PGF2α formation during pregnancy. British pregnant women were randomised to two portions of farmed salmon weekly (n=47), or maintenance of their normal diet low in fish (n=41), from pregnancy week 20 until parturition. The concentrations of eicosapentaenoic and docosahexaenoic acids in plasma phosphatidylcholine (PC) were higher and the concentration of arachidonic acid in plasma PC was lower in the salmon group than the control group at weeks 34 and 38 of pregnancy. PGF2α formation was evaluated by urinary measurement of 15-keto-dihydro-PGF2α, a major PGF2α metabolite, at 20, 34 and 38 weeks. In both the salmon and control groups urinary 15-keto-dihydro-PGF2α concentrations increased significantly during pregnancy, which may be of physiological importance. Oily fish intervention altered fatty acid concentrations but did not affect urinary 15-keto-dihydro-PGF2α concentrations in pregnant women.

Full text not available from this repository.

More information

e-pub ahead of print date: 1 November 2011
Published date: January 2012
Keywords: prostaglandin F2a, pregnancy, salmon, n-3 long chain polyunsaturated fatty acidsAllergyCOX
Organisations: Faculty of Health Sciences


Local EPrints ID: 208359
PURE UUID: 9ce3a8c8-39c4-4ff6-bb36-7559ff223f5c
ORCID for Elizabeth A. Miles: ORCID iD
ORCID for Keith M. Godfrey: ORCID iD

Catalogue record

Date deposited: 19 Jan 2012 10:00
Last modified: 28 Aug 2017 22:41

Export record


Author: Johanna Helmersson-Karlqvist
Author: Elizabeth A. Miles ORCID iD
Author: Maria Vlachava
Author: Lefkothea-Stella Kremmyda
Author: Paul S. Noakes
Author: Norma D. Diaper
Author: Samar Basu

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.