Synthesis of P-chirogenic diarylphosphinoacetic acids and their proline derivatives for palladium-catalysed allylic alkylation reactions

Lam, Hubert, Horton, Peter N., Hursthouse, Michael B., Aldous, D.avid J. and Hii, King Kuok (Mimi) (2005) Synthesis of P-chirogenic diarylphosphinoacetic acids and their proline derivatives for palladium-catalysed allylic alkylation reactions. Tetrahedron Letters, 46 (47), 8145-8148. (doi:10.1016/j.tetlet.2005.09.136).

Abstract

The synthesis of P-chirogenic diarylphosphinocarboxylic acids was achieved, from which a new class of amido- and amino -diphosphine ligands (PNP*) were derived, containing an L-proline backbone. The catalytic activities of the novel ligands were evaluated in the palladium-catalysed allylic alkylation reaction of 1,3-diphenylpropenyl acetate.

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