Animal models of maternal nutrition and altered offspring bone structure
Animal models of maternal nutrition and altered offspring bone structure
It is widely accepted that the likelihood of offspring developing heart disease, stroke, or diabetes in later life, is influenced by the their in utero environment and maternal nutrition. There is increasing epidemiological evidence that osteoporosis in the offspring may also be influenced by the mother’s nutrition during pregnancy. This review provides evidence from a range of animal models that supports the epidemiological data; suggesting that lifelong bone development and growth in offspring is determined during gestation.
animal models, bone, bone development, epidemiology, epigenetics
321-332
Lanham, S.A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Bertram, C.
9af371e3-b87a-4108-b787-64119094731b
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Oreffo, R.O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
24 November 2011
Lanham, S.A.
28fdbbef-e3b6-4fdf-bd0f-4968eeb614d6
Bertram, C.
9af371e3-b87a-4108-b787-64119094731b
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Oreffo, R.O.
ff9fff72-6855-4d0f-bfb2-311d0e8f3778
Lanham, S.A., Bertram, C., Cooper, C. and Oreffo, R.O.
(2011)
Animal models of maternal nutrition and altered offspring bone structure.
European Cells & Materials, 22, .
(PMID:22116650)
Abstract
It is widely accepted that the likelihood of offspring developing heart disease, stroke, or diabetes in later life, is influenced by the their in utero environment and maternal nutrition. There is increasing epidemiological evidence that osteoporosis in the offspring may also be influenced by the mother’s nutrition during pregnancy. This review provides evidence from a range of animal models that supports the epidemiological data; suggesting that lifelong bone development and growth in offspring is determined during gestation.
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Published date: 24 November 2011
Keywords:
animal models, bone, bone development, epidemiology, epigenetics
Organisations:
Faculty of Health Sciences
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Local EPrints ID: 208643
URI: http://eprints.soton.ac.uk/id/eprint/208643
PURE UUID: 38aef051-e571-4174-b7e2-e76f97f1c2e1
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Date deposited: 23 Jan 2012 11:49
Last modified: 18 Mar 2024 02:51
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Author:
S.A. Lanham
Author:
C. Bertram
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