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Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass

Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass
Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass
Alterations in expression of the imprinted gene PHLDA2 are linked to low birth weight in both humans and the mouse. However birth weight is a summary measure of fetal growth and provides little information on the growth rate of the fetus in early and late pregnancy. To examine the relation of PHLDA2expression with rates of fetal growth and explore associations with the infant's body composition in early childhood, we measured PHLDA2 mRNA levels in the term placenta of 102 infants whose mothers were participating in the Southampton Women's Survey (SWS). Higher PHLDA2expression was associated with a lower fetal femur growth velocity between 19 and 34 weeks gestation. In addition, higher placentalPHLDA2 gene expression was associated with a lower child's bone mineral content at four years of age, measured using dual-energy X-ray absorptiometry. The results suggest that placentalPHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction
phlda2, fetal growth, bone mineral content, imprinted genes, placenta
8756-3282
337-342
Lewis, R.M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Cleal, J.K.
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Ntani, G.
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Crozier, S.R.
a97b1967-f6af-413a-8eb0-69fa25534d68
Mahon, Pamela A.
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Robinson, S.M.
ba591c98-4380-456a-be8a-c452f992b69b
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, K.M.
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Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
John, R.M.
acbedd2c-fa18-4295-92f4-9595a3bf10ab
Lewis, R.M.
caaeb97d-ea69-4f7b-8adb-5fa25e2d3502
Cleal, J.K.
18cfd2c1-bd86-4a13-b38f-c321af56da66
Ntani, G.
9b009e0a-5ab2-4c6e-a9fd-15a601e92be5
Crozier, S.R.
a97b1967-f6af-413a-8eb0-69fa25534d68
Mahon, Pamela A.
5a824126-9030-4e8a-9a0e-dafb8aa280f9
Robinson, S.M.
ba591c98-4380-456a-be8a-c452f992b69b
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Inskip, H.M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, K.M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
John, R.M.
acbedd2c-fa18-4295-92f4-9595a3bf10ab

Lewis, R.M., Cleal, J.K. and Ntani, G. et al. (2012) Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass. Bone, 50 (1), 337-342. (doi:10.1016/j.bone.2011.11.003). (PMID:22100507)

Record type: Article

Abstract

Alterations in expression of the imprinted gene PHLDA2 are linked to low birth weight in both humans and the mouse. However birth weight is a summary measure of fetal growth and provides little information on the growth rate of the fetus in early and late pregnancy. To examine the relation of PHLDA2expression with rates of fetal growth and explore associations with the infant's body composition in early childhood, we measured PHLDA2 mRNA levels in the term placenta of 102 infants whose mothers were participating in the Southampton Women's Survey (SWS). Higher PHLDA2expression was associated with a lower fetal femur growth velocity between 19 and 34 weeks gestation. In addition, higher placentalPHLDA2 gene expression was associated with a lower child's bone mineral content at four years of age, measured using dual-energy X-ray absorptiometry. The results suggest that placentalPHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction

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More information

e-pub ahead of print date: 10 November 2011
Published date: January 2012
Keywords: phlda2, fetal growth, bone mineral content, imprinted genes, placenta
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 208775
URI: http://eprints.soton.ac.uk/id/eprint/208775
ISSN: 8756-3282
PURE UUID: 94dbc0bb-f3c4-49af-9a2e-f3ca92f08dba
ORCID for R.M. Lewis: ORCID iD orcid.org/0000-0003-4044-9104
ORCID for J.K. Cleal: ORCID iD orcid.org/0000-0001-7978-4327
ORCID for S.M. Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for N.C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for H.M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for K.M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

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Date deposited: 23 Jan 2012 12:12
Last modified: 18 Mar 2024 02:58

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Contributors

Author: R.M. Lewis ORCID iD
Author: J.K. Cleal ORCID iD
Author: G. Ntani
Author: S.R. Crozier
Author: Pamela A. Mahon
Author: S.M. Robinson ORCID iD
Author: N.C. Harvey ORCID iD
Author: C. Cooper ORCID iD
Author: H.M. Inskip ORCID iD
Author: K.M. Godfrey ORCID iD
Author: Mark A. Hanson ORCID iD
Author: R.M. John

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