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Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass

Lewis, R.M., Cleal, J.K. and Ntani, G. et al. (2012) Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass Bone, 50, (1), pp. 337-342. (PMID:22100507).

Record type: Article


Alterations in expression of the imprinted gene PHLDA2 are linked to low birth weight in both humans and the mouse. However birth weight is a summary measure of fetal growth and provides little information on the growth rate of the fetus in early and late pregnancy. To examine the relation of PHLDA2expression with rates of fetal growth and explore associations with the infant's body composition in early childhood, we measured PHLDA2 mRNA levels in the term placenta of 102 infants whose mothers were participating in the Southampton Women's Survey (SWS). Higher PHLDA2expression was associated with a lower fetal femur growth velocity between 19 and 34 weeks gestation. In addition, higher placentalPHLDA2 gene expression was associated with a lower child's bone mineral content at four years of age, measured using dual-energy X-ray absorptiometry. The results suggest that placentalPHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction

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e-pub ahead of print date: 10 November 2011
Published date: January 2012
Keywords: phlda2, fetal growth, bone mineral content, imprinted genes, placenta
Organisations: Faculty of Health Sciences


Local EPrints ID: 208775
ISSN: 8756-3282
PURE UUID: 94dbc0bb-f3c4-49af-9a2e-f3ca92f08dba
ORCID for R.M. Lewis: ORCID iD
ORCID for S.M. Robinson: ORCID iD
ORCID for C. Cooper: ORCID iD
ORCID for H.M. Inskip: ORCID iD
ORCID for K.M. Godfrey: ORCID iD

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Date deposited: 23 Jan 2012 12:12
Last modified: 29 Aug 2017 02:04

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Author: R.M. Lewis ORCID iD
Author: J.K. Cleal
Author: G. Ntani
Author: S.R. Crozier
Author: Pamela A. Mahon
Author: S.M. Robinson ORCID iD
Author: N.C. Harvey
Author: C. Cooper ORCID iD
Author: H.M. Inskip ORCID iD
Author: K.M. Godfrey ORCID iD
Author: Mark A. Hanson
Author: R.M. John

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