Intralipid therapy for recurrent implantation failure: new hope or false dawn?

Shreeve, N. and Sadek, K. (2011) Intralipid therapy for recurrent implantation failure: new hope or false dawn? Journal of Reproductive Immunology (doi:10.1016/j.jri.2011.11.003). (PMID:22196107).


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Recurrent embryo implantation failure (RIF) is a disorder with potentially devastating physiological and psychological manifestations for those affected. Although its prevalence is not uncommon, many of the mechanisms involved still require elucidation. Both organ-specific and systemic autoimmunity are associated with an increased prevalence of recurrent miscarriage and reproductive failure, rendering the role of the maternal immunological system in fertility a key concept. It is believed by some that central to this theme is the maternal cytokine profile, with particularly T-helper (Th) cells. Immune modulating therapies have therefore been mooted as potential therapeutic strategies. Recent reports of high pregnancy rates achievable in women with RIF have added fuel to the debate regarding the effectiveness of intralipid in modulating the immune system. We would like to assess if there is sufficient current evidence of acceptable quality to permit an assumption that intralipid therapy is an effective treatment for women undergoing repeated assisted reproduction cycles. We have concluded that appropriately controlled, large-scale, confirmatory studies are necessary to prove the efficacy of intralipid before it can be recommended for routine use.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.jri.2011.11.003
ISSNs: 0165-0378 (print)
Related URLs:
Keywords: recurrent implantation failure, intralipid, T-helper cells, Th1
Organisations: Faculty of Medicine
ePrint ID: 208825
Date :
Date Event
21 December 2011e-pub ahead of print
Date Deposited: 24 Jan 2012 16:03
Last Modified: 18 Apr 2017 00:32
Further Information:Google Scholar

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