The University of Southampton
University of Southampton Institutional Repository

Spontaneous LH surges prior to hCG administration in unstimulated-cycle frozen-thawed embryo transfer do not influence pregnancy rates

Groenewoud, E. R., Kollen, B. J., Macklon, N. S. and Cohlen, B. J. (2011) Spontaneous LH surges prior to hCG administration in unstimulated-cycle frozen-thawed embryo transfer do not influence pregnancy rates Reproductive Biomedicine Online (doi:10.1016/j.rbmo.2011.11.003). (PMID:22197128).

Record type: Article

Abstract

LH surges are the start of a period of optimal endometrial receptivity. Missing these surges in an unstimulated-cycle frozen-thawed embryo transfer (FET) based on ultrasound alone might lead to incorrect timing of embryo transfer. This prospective, non-randomized trial established the incidence and effect of spontaneous LH surges on ongoing pregnancy rates and assessed the use of ultrasound without LH monitoring in planning FET. All patients undergoing unstimulated-cycle FET in the study centre over a 2-year period were included in this analysis (n=233). All patients had regular menstrual cycles. Serum LH analysis took place before human chorionic gonadotrophin administration. The main outcome measure was ongoing pregnancy. LH surges occurred in over half of patients. Overall pregnancy rate was 34.3%. Relative risks for ongoing pregnancy for cycles with or without a spontaneous LH surge were not significantly different (ongoing pregnancy rate 33.4% versus 34.8%; RR 1.02, 95% CI 0.7-1.5). Based on these results, it was concluded that LH surges ?10 IU/l occurred in over 50% of patients, but LH surges demonstrated no significant effect on pregnancy rates. Single LH determination prior to ovulation induction in unstimulated-cycle FET does not seem to have added clinical value. LH surges are the start of a period of fertility. Missing these surges in natural-cycle frozen-thawed embryo transfer (FET) based on ultrasound alone might lead to incorrect timing of thawing and transferring. This can subsequently lead to diminished pregnancy rates. In this trial we established both the incidence and effect of these LH surges on ongoing pregnancy rates and assessed the use of ultrasound without LH monitoring in planning natural-cycle FET. Over a 2-year period, all patients undergoing natural-cycle FET in our centre were included in this analysis (n=233). All patients had a regular menstrual cycle. Analyses of the LH concentration took place before ovulation induction with human chorionic gonadotrophin in natural-cycle FET. The main outcome measure was ongoing pregnancy. LH surges occurred in over half of all patients. The overall pregnancy rate was 34.3%. No difference was found in pregnancy rates between patients with and without an LH surge. Based on these results, we concluded that LH surges occurred in over 50% of all patients, but these surges demonstrated no significant effect on pregnancy rates. Regular ultrasound evaluation of the dominant follicle alone seems to be an accurate method to plan natural-cycle FET.

Full text not available from this repository.

More information

e-pub ahead of print date: 10 November 2011
Keywords: embryo transfer, frozen embryo transfer, LH, unstimulated cycle
Organisations: Human Development & Health

Identifiers

Local EPrints ID: 208919
URI: http://eprints.soton.ac.uk/id/eprint/208919
ISSN: 1472-6483
PURE UUID: 652cc54c-55e7-4577-a457-1ddca371db5d

Catalogue record

Date deposited: 24 Jan 2012 12:50
Last modified: 18 Jul 2017 10:47

Export record

Altmetrics

Contributors

Author: E. R. Groenewoud
Author: B. J. Kollen
Author: N. S. Macklon
Author: B. J. Cohlen

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×