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Fluorescence based strategies for genetic analysis

Fluorescence based strategies for genetic analysis
Fluorescence based strategies for genetic analysis
Synthetic chemistry has been central to the design of modern methods of genetic analysis. In this article, we discuss the underlying chemistry and biophysical principles that have been used in the development of robust methods for the analysis of DNA in the diagnostic laboratory.
polymerase-chain-reaction, light-up probes, real-time pcr, nucleic-acid hybridization, resonance energy-transfer, quantitative rt-pcr, molecular beacons, scorpion primers, thiazole orange, labeledoligonucleotides
1359-7345
5487-5502
Ranasinghe, Rohan T.
b29fc8b4-2a66-430a-85fa-ff1c9c261f32
Brown, Tom
1cd7df32-b945-4ca1-8b59-a51a30191472
Ranasinghe, Rohan T.
b29fc8b4-2a66-430a-85fa-ff1c9c261f32
Brown, Tom
1cd7df32-b945-4ca1-8b59-a51a30191472

Ranasinghe, Rohan T. and Brown, Tom (2005) Fluorescence based strategies for genetic analysis. Chemical Communications, (44), 5487-5502. (doi:10.1039/b509522k).

Record type: Article

Abstract

Synthetic chemistry has been central to the design of modern methods of genetic analysis. In this article, we discuss the underlying chemistry and biophysical principles that have been used in the development of robust methods for the analysis of DNA in the diagnostic laboratory.

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More information

Published date: 28 November 2005
Keywords: polymerase-chain-reaction, light-up probes, real-time pcr, nucleic-acid hybridization, resonance energy-transfer, quantitative rt-pcr, molecular beacons, scorpion primers, thiazole orange, labeledoligonucleotides
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Identifiers

Local EPrints ID: 20894
URI: http://eprints.soton.ac.uk/id/eprint/20894
DOI: doi:10.1039/b509522k
ISSN: 1359-7345
PURE UUID: 283dbc42-0eb7-4e12-a9e8-e57a51215b50

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Date deposited: 28 Feb 2006
Last modified: 15 Mar 2024 06:26

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Contributors

Author: Rohan T. Ranasinghe
Author: Tom Brown

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