PS-IIDQ: an efficient polymer-supported amide coupling reagent
PS-IIDQ: an efficient polymer-supported amide coupling reagent
Polystyrene-IIDQis a polymer-supported coupling reagent that couples carboxylic acids to amines in good yields and high purity without the requirement of a pre-activation step. Importantly the order of addition of the amine, acid or coupling agent makes no difference to the efficiency of the coupling reaction and the reagent can be readily regenerated.
chloride bop-cl, peptide-synthesis, racemization, pybop, acids
1164-1166
Valeur, Eric
2c7b8b91-aa40-4d6f-8d25-7fc0296d7335
Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900
2005
Valeur, Eric
2c7b8b91-aa40-4d6f-8d25-7fc0296d7335
Bradley, Mark
562b9add-34c4-4620-bfa1-c7c83a0f0900
Valeur, Eric and Bradley, Mark
(2005)
PS-IIDQ: an efficient polymer-supported amide coupling reagent.
Chemical Communications, (9), .
(doi:10.1039/b414889d).
Abstract
Polystyrene-IIDQis a polymer-supported coupling reagent that couples carboxylic acids to amines in good yields and high purity without the requirement of a pre-activation step. Importantly the order of addition of the amine, acid or coupling agent makes no difference to the efficiency of the coupling reaction and the reagent can be readily regenerated.
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Published date: 2005
Additional Information:
ChemComm
Keywords:
chloride bop-cl, peptide-synthesis, racemization, pybop, acids
Identifiers
Local EPrints ID: 20921
URI: http://eprints.soton.ac.uk/id/eprint/20921
ISSN: 1359-7345
PURE UUID: 09d8af6f-8f70-4db7-9b6c-cd452742d67c
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Date deposited: 01 Mar 2006
Last modified: 15 Mar 2024 06:26
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Author:
Eric Valeur
Author:
Mark Bradley
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