Long term respiratory consequences of intrauterine growth restriction
Long term respiratory consequences of intrauterine growth restriction
Epidemiological studies demonstrate that in-utero growth restriction and low birth weight are associated with impaired lung function and increased respiratory morbidity from infancy, throughout childhood and into adulthood. Chronic restriction of nutrients and/or oxygen during late pregnancy causes abnormalities in the airways and lungs of offspring, including smaller numbers of enlarged alveoli with thicker septal walls and basement membranes. The structural abnormalities and impaired lung function seen soon after birth persist or even progress with age. These changes are likely to cause lung symptomology through life and hasten lung aging.
adult, fetal, intrauterine growth restriction, lung, lung function, lung maturation
92-98
Pike, Katharine
10be90c8-73de-416e-a2d0-0bb7e7276bd3
Pillow, J. Jane
0ed15124-e9bf-4651-9faf-346766ff3d4e
Lucas, Jane S.
5cb3546c-87b2-4e59-af48-402076e25313
April 2012
Pike, Katharine
10be90c8-73de-416e-a2d0-0bb7e7276bd3
Pillow, J. Jane
0ed15124-e9bf-4651-9faf-346766ff3d4e
Lucas, Jane S.
5cb3546c-87b2-4e59-af48-402076e25313
Pike, Katharine, Pillow, J. Jane and Lucas, Jane S.
(2012)
Long term respiratory consequences of intrauterine growth restriction.
Seminars in Fetal and Neonatal Medicine, 17 (2), .
(doi:10.1016/j.siny.2012.01.003).
(PMID:22277109)
Abstract
Epidemiological studies demonstrate that in-utero growth restriction and low birth weight are associated with impaired lung function and increased respiratory morbidity from infancy, throughout childhood and into adulthood. Chronic restriction of nutrients and/or oxygen during late pregnancy causes abnormalities in the airways and lungs of offspring, including smaller numbers of enlarged alveoli with thicker septal walls and basement membranes. The structural abnormalities and impaired lung function seen soon after birth persist or even progress with age. These changes are likely to cause lung symptomology through life and hasten lung aging.
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e-pub ahead of print date: January 2012
Published date: April 2012
Keywords:
adult, fetal, intrauterine growth restriction, lung, lung function, lung maturation
Organisations:
Clinical & Experimental Sciences
Identifiers
Local EPrints ID: 209395
URI: http://eprints.soton.ac.uk/id/eprint/209395
PURE UUID: caf60d47-700d-41bc-b71d-e3896a6c61c1
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Date deposited: 30 Jan 2012 14:22
Last modified: 15 Mar 2024 03:12
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Contributors
Author:
Katharine Pike
Author:
J. Jane Pillow
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