Long term respiratory consequences of intrauterine growth restriction

Pike, Katharine, Pillow, J. Jane and Lucas, Jane S. (2012) Long term respiratory consequences of intrauterine growth restriction Seminars in Fetal & Neonatal Medicine, 17, (2), pp. 92-98. (doi:10.1016/j.siny.2012.01.003). (PMID:22277109).


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Epidemiological studies demonstrate that in-utero growth restriction and low birth weight are associated with impaired lung function and increased respiratory morbidity from infancy, throughout childhood and into adulthood. Chronic restriction of nutrients and/or oxygen during late pregnancy causes abnormalities in the airways and lungs of offspring, including smaller numbers of enlarged alveoli with thicker septal walls and basement membranes. The structural abnormalities and impaired lung function seen soon after birth persist or even progress with age. These changes are likely to cause lung symptomology through life and hasten lung aging.

Item Type: Article
Digital Object Identifier (DOI): doi:10.1016/j.siny.2012.01.003
Keywords: adult, fetal, intrauterine growth restriction, lung, lung function, lung maturation
Organisations: Clinical & Experimental Sciences
ePrint ID: 209395
Date :
Date Event
January 2012e-pub ahead of print
April 2012Published
Date Deposited: 30 Jan 2012 14:22
Last Modified: 18 Apr 2017 00:30
Further Information:Google Scholar
URI: http://eprints.soton.ac.uk/id/eprint/209395

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