The University of Southampton
University of Southampton Institutional Repository

The association between hip morphology parameters and nineteen-year risk of end-stage osteoarthritis of the hip: a nested case-control study.

The association between hip morphology parameters and nineteen-year risk of end-stage osteoarthritis of the hip: a nested case-control study.
The association between hip morphology parameters and nineteen-year risk of end-stage osteoarthritis of the hip: a nested case-control study.
Objective. Subtle deformities of the hip joint are
implicated in the etiology of osteoarthritis (OA) of the
hip. Parameters that quantify these deformities may aid
understanding of these associations. We undertook this
study to examine relationships between such parameters
and the 19-year risk of total hip arthroplasty
(THA) for end-stage OA.
Methods. A new software program designed for
measuring morphologic parameters around the hip was
developed and validated in a reliability study. THA was
the outcome measure for end-stage OA. A nested case–
control study was used with individuals from a cohort of
1,003 women who were recruited at year 1 in 1989 and
followed up to year 20 (the Chingford Study). All hips
with THA by year 20 and 243 randomly selected control
hips were studied. Pelvis radiographs obtained at year 2
were analyzed for variations in hip morphology. Measurements
were compared between the THA case group
and the control group.
Results. Patients with THA had a higher prevalence
of cam deformity than did their respective controls
(median alpha angle 62.4° versus 45.8° [P ? 0.001];
mean modified triangular index height 28.5 mm versus
26.9 mm [P ? 0.001]) as well as a higher prevalence of
acetabular dysplasia (mean lateral center edge angle
29.5° versus 34.3° [P ? 0.001]; median extrusion index
0.25 versus 0.185 [P ? 0.009]). Logistic regression
analyses clustering by subject and adjusting for radiographic
hip OA at year 2 showed that these morphologic
parameters were still significantly associated with THA
by year 20. The alpha angle and lateral center edge
angle predicted the risk of THA independently when
included in the same model.
Conclusion. This investigation describes measurements
that predict the risk of THA for end-stage OA
by year 20, independently of the presence of radiographic
hip OA at year 2. These measurements can be
made on an anteroposterior pelvis radiograph, which is
an inexpensive and commonly used clinical method of
investigation.
0004-3591
3392-3400
Nicolls, Alex S.
c5b03d7f-affd-4492-b212-1f798daa4879
Kiran, Amit
4b4006e4-c155-408b-ac66-6342c7b3d0ee
Pollard, Thomas C. B.
4a69e2f5-0001-48bb-8efa-8b27848acafc
Hart, Deborah J.
4f5ca470-3877-4d29-b0ab-4127bdf8b361
Arden, Charlotte P. A.
3f44ac65-3e4c-4fc4-ab16-3a96dadb634d
Spector, Tim
b8289355-8b82-4ec4-bfd7-56e85af732ca
Gill, H. S.
f727d249-2008-4c7b-8b33-959b8a6a416a
Murray, David W.
fa0e1764-e600-42bd-937d-6d7e5d623bbc
Carr, Andrew J.
f37df723-ef0e-4c91-92f2-733145030178
Arden, Nigel K.
23af958d-835c-4d79-be54-4bbe4c68077f
Nicolls, Alex S.
c5b03d7f-affd-4492-b212-1f798daa4879
Kiran, Amit
4b4006e4-c155-408b-ac66-6342c7b3d0ee
Pollard, Thomas C. B.
4a69e2f5-0001-48bb-8efa-8b27848acafc
Hart, Deborah J.
4f5ca470-3877-4d29-b0ab-4127bdf8b361
Arden, Charlotte P. A.
3f44ac65-3e4c-4fc4-ab16-3a96dadb634d
Spector, Tim
b8289355-8b82-4ec4-bfd7-56e85af732ca
Gill, H. S.
f727d249-2008-4c7b-8b33-959b8a6a416a
Murray, David W.
fa0e1764-e600-42bd-937d-6d7e5d623bbc
Carr, Andrew J.
f37df723-ef0e-4c91-92f2-733145030178
Arden, Nigel K.
23af958d-835c-4d79-be54-4bbe4c68077f

Nicolls, Alex S., Kiran, Amit, Pollard, Thomas C. B., Hart, Deborah J., Arden, Charlotte P. A., Spector, Tim, Gill, H. S., Murray, David W., Carr, Andrew J. and Arden, Nigel K. (2011) The association between hip morphology parameters and nineteen-year risk of end-stage osteoarthritis of the hip: a nested case-control study. Arthritis & Rheumatism, 63 (11), 3392-3400. (doi:10.1002/art.30523). (PMID:21739424)

Record type: Article

Abstract

Objective. Subtle deformities of the hip joint are
implicated in the etiology of osteoarthritis (OA) of the
hip. Parameters that quantify these deformities may aid
understanding of these associations. We undertook this
study to examine relationships between such parameters
and the 19-year risk of total hip arthroplasty
(THA) for end-stage OA.
Methods. A new software program designed for
measuring morphologic parameters around the hip was
developed and validated in a reliability study. THA was
the outcome measure for end-stage OA. A nested case–
control study was used with individuals from a cohort of
1,003 women who were recruited at year 1 in 1989 and
followed up to year 20 (the Chingford Study). All hips
with THA by year 20 and 243 randomly selected control
hips were studied. Pelvis radiographs obtained at year 2
were analyzed for variations in hip morphology. Measurements
were compared between the THA case group
and the control group.
Results. Patients with THA had a higher prevalence
of cam deformity than did their respective controls
(median alpha angle 62.4° versus 45.8° [P ? 0.001];
mean modified triangular index height 28.5 mm versus
26.9 mm [P ? 0.001]) as well as a higher prevalence of
acetabular dysplasia (mean lateral center edge angle
29.5° versus 34.3° [P ? 0.001]; median extrusion index
0.25 versus 0.185 [P ? 0.009]). Logistic regression
analyses clustering by subject and adjusting for radiographic
hip OA at year 2 showed that these morphologic
parameters were still significantly associated with THA
by year 20. The alpha angle and lateral center edge
angle predicted the risk of THA independently when
included in the same model.
Conclusion. This investigation describes measurements
that predict the risk of THA for end-stage OA
by year 20, independently of the presence of radiographic
hip OA at year 2. These measurements can be
made on an anteroposterior pelvis radiograph, which is
an inexpensive and commonly used clinical method of
investigation.

This record has no associated files available for download.

More information

e-pub ahead of print date: 28 October 2011
Published date: November 2011
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 209617
URI: http://eprints.soton.ac.uk/id/eprint/209617
ISSN: 0004-3591
PURE UUID: 431cdbe5-820d-404a-b7df-3700f42f84be

Catalogue record

Date deposited: 31 Jan 2012 12:46
Last modified: 14 Mar 2024 04:46

Export record

Altmetrics

Contributors

Author: Alex S. Nicolls
Author: Amit Kiran
Author: Thomas C. B. Pollard
Author: Deborah J. Hart
Author: Charlotte P. A. Arden
Author: Tim Spector
Author: H. S. Gill
Author: David W. Murray
Author: Andrew J. Carr
Author: Nigel K. Arden

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×