The University of Southampton
University of Southampton Institutional Repository

Venous liver blood flow and regulation of human fetal growth: evidence from macrosomic fetuses

Venous liver blood flow and regulation of human fetal growth: evidence from macrosomic fetuses
Venous liver blood flow and regulation of human fetal growth: evidence from macrosomic fetuses
OBJECTIVE: Experimental studies show that fetal liver venous perfusion
is a determinant for growth in utero. Here we explore the relationship
between fetal venous blood flow to the liver and macrosomia.
STUDY DESIGN: From diameter and blood flow velocity measurements,
we derived liver venous blood flow in a longitudinal ultrasound
study of 25 macrosomic fetuses of nondiabetic mothers during the second
half of pregnancy.
RESULTS: Compared with appropriately growing fetuses, macrosomic
fetuses directed more umbilical blood to the liver tissue, with correspondingly
less contribution from the portal circulation when normalized
for fetal weight. Whereas total venous liver blood flow showed no
late gestation rise in the reference population, it continued to increase in
macrosomic fetuses and was accompanied by greater fetal weight.
CONCLUSION: The direct relationship between venous liver blood flow
and macrosomia in the fetus supports the concept that intrauterine
growth is linked to the amount and distributional pattern of venous liver
perfusion.
blood flow, Doppler ultrasound, fetus, liver, macrosomia
0002-9378
429-437
Kessler, Jörg
2112d15d-24b5-48c0-a800-40f1cd70a05b
Rasmussen, Svein
553e2196-bbb7-4a95-a583-792b2b5a65b9
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Kiserud, Torvid
a7689962-989b-4f84-ae1a-dbc10b57c5f9
Kessler, Jörg
2112d15d-24b5-48c0-a800-40f1cd70a05b
Rasmussen, Svein
553e2196-bbb7-4a95-a583-792b2b5a65b9
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Hanson, Mark A.
1952fad1-abc7-4284-a0bc-a7eb31f70a3f
Kiserud, Torvid
a7689962-989b-4f84-ae1a-dbc10b57c5f9

Kessler, Jörg, Rasmussen, Svein, Godfrey, Keith M., Hanson, Mark A. and Kiserud, Torvid (2011) Venous liver blood flow and regulation of human fetal growth: evidence from macrosomic fetuses. American Journal of Obstetrics and Gynecology, 204 (5), 429-437. (doi:10.1016/j.ajog.2010.12.038). (PMID:21354546)

Record type: Article

Abstract

OBJECTIVE: Experimental studies show that fetal liver venous perfusion
is a determinant for growth in utero. Here we explore the relationship
between fetal venous blood flow to the liver and macrosomia.
STUDY DESIGN: From diameter and blood flow velocity measurements,
we derived liver venous blood flow in a longitudinal ultrasound
study of 25 macrosomic fetuses of nondiabetic mothers during the second
half of pregnancy.
RESULTS: Compared with appropriately growing fetuses, macrosomic
fetuses directed more umbilical blood to the liver tissue, with correspondingly
less contribution from the portal circulation when normalized
for fetal weight. Whereas total venous liver blood flow showed no
late gestation rise in the reference population, it continued to increase in
macrosomic fetuses and was accompanied by greater fetal weight.
CONCLUSION: The direct relationship between venous liver blood flow
and macrosomia in the fetus supports the concept that intrauterine
growth is linked to the amount and distributional pattern of venous liver
perfusion.

This record has no associated files available for download.

More information

Published date: May 2011
Keywords: blood flow, Doppler ultrasound, fetus, liver, macrosomia
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 210958
URI: http://eprints.soton.ac.uk/id/eprint/210958
ISSN: 0002-9378
PURE UUID: 0955170a-4560-44e8-8483-9c3968dd92e3
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618
ORCID for Mark A. Hanson: ORCID iD orcid.org/0000-0002-6907-613X

Catalogue record

Date deposited: 15 Feb 2012 12:48
Last modified: 15 Mar 2024 03:07

Export record

Altmetrics

Contributors

Author: Jörg Kessler
Author: Svein Rasmussen
Author: Mark A. Hanson ORCID iD
Author: Torvid Kiserud

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×