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Venous liver blood flow and regulation of human fetal growth: evidence from macrosomic fetuses

Record type: Article

OBJECTIVE: Experimental studies show that fetal liver venous perfusion
is a determinant for growth in utero. Here we explore the relationship
between fetal venous blood flow to the liver and macrosomia.
STUDY DESIGN: From diameter and blood flow velocity measurements,
we derived liver venous blood flow in a longitudinal ultrasound
study of 25 macrosomic fetuses of nondiabetic mothers during the second
half of pregnancy.
RESULTS: Compared with appropriately growing fetuses, macrosomic
fetuses directed more umbilical blood to the liver tissue, with correspondingly
less contribution from the portal circulation when normalized
for fetal weight. Whereas total venous liver blood flow showed no
late gestation rise in the reference population, it continued to increase in
macrosomic fetuses and was accompanied by greater fetal weight.
CONCLUSION: The direct relationship between venous liver blood flow
and macrosomia in the fetus supports the concept that intrauterine
growth is linked to the amount and distributional pattern of venous liver
perfusion.

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Citation

Kessler, Jörg, Rasmussen, Svein, Godfrey, Keith M., Hanson, Mark A. and Kiserud, Torvid (2011) Venous liver blood flow and regulation of human fetal growth: evidence from macrosomic fetuses American Journal of Obstetrics and Gynecology, 204, (5), pp. 429-437. (doi:10.1016/j.ajog.2010.12.038). (PMID:21354546).

More information

Published date: May 2011
Keywords: blood flow, Doppler ultrasound, fetus, liver, macrosomia
Organisations: Faculty of Health Sciences

Identifiers

Local EPrints ID: 210958
URI: http://eprints.soton.ac.uk/id/eprint/210958
ISSN: 0002-9378
PURE UUID: 0955170a-4560-44e8-8483-9c3968dd92e3
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 15 Feb 2012 12:48
Last modified: 18 Jul 2017 10:44

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Contributors

Author: Jörg Kessler
Author: Svein Rasmussen
Author: Mark A. Hanson
Author: Torvid Kiserud

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