Tunable transmembrane chloride transport by bis-indolylureas
Tunable transmembrane chloride transport by bis-indolylureas
A series of bis-indolylureas have been found to mediate chloride transport across vesicle bilayers. The anion transport activity of these receptors may be readily modulated by small structural changes to the receptor scaffold as shown by the combination of experimental chloride efflux studies and molecular dynamics simulations in water and POPC bilayer
1436-1444
Haynes, Cally J.E.
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Moore, Stephen J.
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Hiscock, Jennifer R.
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Marques, Igor
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Costa, Paulo Jorge
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Félix, Vítor
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Gale, Philip A.
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Haynes, Cally J.E.
c56ceaa2-ca95-4ef6-bcce-c5cb825c2ca0
Moore, Stephen J.
34bf8d61-0e01-4e6c-95e9-3e2cad590a1b
Hiscock, Jennifer R.
99a8a34c-a869-48e2-b713-1e69e4741032
Marques, Igor
97cbc26e-6d94-43e6-a934-1d69dad8de06
Costa, Paulo Jorge
8e79020e-1827-4a96-bc89-64f5f5ecc13e
Félix, Vítor
b4098ac2-b86b-48f3-af11-c767e24fac6e
Gale, Philip A.
c840b7e9-6847-4843-91af-fa0f8563d943
Haynes, Cally J.E., Moore, Stephen J., Hiscock, Jennifer R., Marques, Igor, Costa, Paulo Jorge, Félix, Vítor and Gale, Philip A.
(2012)
Tunable transmembrane chloride transport by bis-indolylureas.
Chemical Science, 3, .
(doi:10.1039/C2SC20041D).
Abstract
A series of bis-indolylureas have been found to mediate chloride transport across vesicle bilayers. The anion transport activity of these receptors may be readily modulated by small structural changes to the receptor scaffold as shown by the combination of experimental chloride efflux studies and molecular dynamics simulations in water and POPC bilayer
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e-pub ahead of print date: 9 February 2012
Identifiers
Local EPrints ID: 210962
URI: http://eprints.soton.ac.uk/id/eprint/210962
ISSN: 1478-6524
PURE UUID: b2e400ed-4cf4-4382-b23f-dce945a29a80
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Date deposited: 16 Feb 2012 15:26
Last modified: 15 Mar 2024 03:06
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Contributors
Author:
Cally J.E. Haynes
Author:
Stephen J. Moore
Author:
Jennifer R. Hiscock
Author:
Igor Marques
Author:
Paulo Jorge Costa
Author:
Vítor Félix
Author:
Philip A. Gale
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