The University of Southampton
University of Southampton Institutional Repository

Can lycopene be delivered into semen via prostasomes? In vitro incorporation and retention studies

Can lycopene be delivered into semen via prostasomes? In vitro incorporation and retention studies
Can lycopene be delivered into semen via prostasomes? In vitro incorporation and retention studies
Lycopene (C40 H56) is a highly lipophilic antioxidant found in human semen in nanomolar concentrations. It has been shown to be one of the most potent carotenoid antioxidant in various human studies. Prostasomes are organelles secreted by glandular prostatic epithelial cells and are known to play an important role in fertility and prostate cancer. They are also known to possess antioxidant activity and aid the functioning of sperm. We studied the ability of these vesicles to adsorb and retain lycopene into their rich lipid environment in vitro. High-performance liquid chromatography analysis confirmed micrograms of lycopene per milligram of prostasomal protein. In view of the prostasomes' lipid-rich nature it is highly likely that these organelles act as delivery vehicles for this highly lipophilic antioxidant substance into human semen.
high-performance liquid chromatography, in vitro studies, lycopene, prostasomes, semen
0105-6263
528-533
Goyal, A.
e3236f2e-22ea-4367-84e4-b2d51f06129e
Delves, G.H.
6148e70a-8575-40e5-a875-2eda6577391c
Chopra, M.
348330de-e71c-42cb-b616-c931e3e9ba95
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Cooper, A.J.
8a21c297-eda3-4479-8e81-1de258c8e2a1
Goyal, A.
e3236f2e-22ea-4367-84e4-b2d51f06129e
Delves, G.H.
6148e70a-8575-40e5-a875-2eda6577391c
Chopra, M.
348330de-e71c-42cb-b616-c931e3e9ba95
Lwaleed, B.A.
e7c59131-82ad-4a14-a227-7370e91e3f21
Cooper, A.J.
8a21c297-eda3-4479-8e81-1de258c8e2a1

Goyal, A., Delves, G.H., Chopra, M., Lwaleed, B.A. and Cooper, A.J. (2006) Can lycopene be delivered into semen via prostasomes? In vitro incorporation and retention studies. International Journal of Andrology, 29 (5), 528-533. (doi:10.1111/j.1365-2605.2006.00690.x).

Record type: Article

Abstract

Lycopene (C40 H56) is a highly lipophilic antioxidant found in human semen in nanomolar concentrations. It has been shown to be one of the most potent carotenoid antioxidant in various human studies. Prostasomes are organelles secreted by glandular prostatic epithelial cells and are known to play an important role in fertility and prostate cancer. They are also known to possess antioxidant activity and aid the functioning of sperm. We studied the ability of these vesicles to adsorb and retain lycopene into their rich lipid environment in vitro. High-performance liquid chromatography analysis confirmed micrograms of lycopene per milligram of prostasomal protein. In view of the prostasomes' lipid-rich nature it is highly likely that these organelles act as delivery vehicles for this highly lipophilic antioxidant substance into human semen.

This record has no associated files available for download.

More information

Published date: 2006
Keywords: high-performance liquid chromatography, in vitro studies, lycopene, prostasomes, semen

Identifiers

Local EPrints ID: 24040
URI: http://eprints.soton.ac.uk/id/eprint/24040
ISSN: 0105-6263
PURE UUID: c311e491-a4f7-4258-8708-01784261f1b9

Catalogue record

Date deposited: 24 Nov 2006
Last modified: 15 Mar 2024 06:51

Export record

Altmetrics

Contributors

Author: A. Goyal
Author: G.H. Delves
Author: M. Chopra
Author: B.A. Lwaleed
Author: A.J. Cooper

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×