The University of Southampton
University of Southampton Institutional Repository

Molecular phylogenetic evidence for an extracellular Cu Zn superoxide dismutase gene in insects

Parker, J.D., Parker, K.M. and Keller, L. (2004) Molecular phylogenetic evidence for an extracellular Cu Zn superoxide dismutase gene in insects Journal of Insect Molecular Biology, 13, (6), pp. 587-594. (doi:10.1111/j.0962-1075.2004.00515.x).

Record type: Article


Representatives of three ancient gene families of the antioxidant enzyme superoxide dismutase (SOD) can be found in most metazoans. In mammals and Caenorhabditis elegans, there is at least one gene each of the cytoplasmic, mitochondrial and extracellular lineages of SOD genes. The cytoplasmic SOD was one of the first enzymes to be implicated in ageing due to its protection against damaging oxygen free radicals. In contrast to other metazoans, insects were thought to lack a gene for the extracellular SOD. We have cloned and sequenced an SOD mRNA in the ant Lasius niger that appears to belong to this extracellular family. Subsequent searches and analyses of SOD gene sequences in insect databases revealed that insects do indeed express all three SOD genes including the extracellular form. We conclude that insects as well as other metazoans appear to have the full repertoire of the three families of SOD.

PDF parker2004_IMB.pdf - Version of Record
Restricted to Registered users only
Download (307kB)

More information

Submitted date: 21 April 2004
Published date: December 2004
Keywords: extracellular superoxide dismutase, ec sod, sod3, sod5, phylogeny


Local EPrints ID: 24043
ISSN: 0962-1075
PURE UUID: dc5fc4b8-02eb-4055-967f-534cbd20d3f7

Catalogue record

Date deposited: 20 Mar 2006
Last modified: 17 Jul 2017 16:15

Export record



Author: J.D. Parker
Author: K.M. Parker
Author: L. Keller

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton:

ePrints Soton supports OAI 2.0 with a base URL of

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.