Structure of yeast 5-aminolaevulinic acid
dehydratase complexed with the inhibitor
5-hydroxylaevulinic acid
Structure of yeast 5-aminolaevulinic acid
dehydratase complexed with the inhibitor
5-hydroxylaevulinic acid
The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase (ALAD) from yeast complexed with the competitive inhibitor 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 Å . The structure shows that the inhibitor is bound by a Schiff-base link to one of the invariant active-site lysine residues (Lys263). The inhibitor appears to bind in two well defined conformations and the interactions made by it suggest that it is a very close analogue of the substrate 5-aminolaevulinic acid (ALA).
5-aminolaevulinicacid dehydratase, 1w31, r1w31sf.
1222-1226
Erskine, P.T.
c77b60c5-b80c-4e6a-a103-bf57ecfcbcf6
Coates, L.
2be36c11-8cb2-4518-a001-953051aa6a23
Newbold, R.
fa67a143-11e2-4e5d-8870-56db80d2f713
Brindley, A.A.
638ed87e-b0f7-4e74-9433-13bcde83aafc
Stauffer, F.
69658c3a-ac98-4259-994e-efab08e13fcd
Beaven, G.D.E
bfba062d-06fd-4c94-821c-23cfdf438304
Gill, R.
95656ecb-604f-425e-ac66-7dd36e47d94d
Coker, A.
c64a7d9b-3a0d-4e79-a3eb-aaa64920116a
Wood, S.P.
430faabf-7f5c-4cf6-9bcc-5955f5e09566
Warren, M.J.
6dc30bb6-c290-490e-8aab-44ad27c7c609
Shoolingin-Jordan, P.M.
ac0bf2cc-ee36-4b30-bcef-525cee2559f7
Neier, R.
8dbdc1db-e80b-4f92-a608-dd97577793d6
Cooper, J.B.
d9f0f6a8-1260-48fc-aa5c-3dbc650e3ec0
2005
Erskine, P.T.
c77b60c5-b80c-4e6a-a103-bf57ecfcbcf6
Coates, L.
2be36c11-8cb2-4518-a001-953051aa6a23
Newbold, R.
fa67a143-11e2-4e5d-8870-56db80d2f713
Brindley, A.A.
638ed87e-b0f7-4e74-9433-13bcde83aafc
Stauffer, F.
69658c3a-ac98-4259-994e-efab08e13fcd
Beaven, G.D.E
bfba062d-06fd-4c94-821c-23cfdf438304
Gill, R.
95656ecb-604f-425e-ac66-7dd36e47d94d
Coker, A.
c64a7d9b-3a0d-4e79-a3eb-aaa64920116a
Wood, S.P.
430faabf-7f5c-4cf6-9bcc-5955f5e09566
Warren, M.J.
6dc30bb6-c290-490e-8aab-44ad27c7c609
Shoolingin-Jordan, P.M.
ac0bf2cc-ee36-4b30-bcef-525cee2559f7
Neier, R.
8dbdc1db-e80b-4f92-a608-dd97577793d6
Cooper, J.B.
d9f0f6a8-1260-48fc-aa5c-3dbc650e3ec0
Erskine, P.T., Coates, L., Newbold, R., Brindley, A.A., Stauffer, F., Beaven, G.D.E, Gill, R., Coker, A., Wood, S.P., Warren, M.J., Shoolingin-Jordan, P.M., Neier, R. and Cooper, J.B.
(2005)
Structure of yeast 5-aminolaevulinic acid
dehydratase complexed with the inhibitor
5-hydroxylaevulinic acid.
Acta Crystallographica Section D: Biological Crystallography, 61, .
(doi:10.1107/S0907444905018834).
Abstract
The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase (ALAD) from yeast complexed with the competitive inhibitor 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 Å . The structure shows that the inhibitor is bound by a Schiff-base link to one of the invariant active-site lysine residues (Lys263). The inhibitor appears to bind in two well defined conformations and the interactions made by it suggest that it is a very close analogue of the substrate 5-aminolaevulinic acid (ALA).
Text
Coker2_05.pdf
- Other
Restricted to Repository staff only
Request a copy
More information
Submitted date: 21 July 2004
Published date: 2005
Keywords:
5-aminolaevulinicacid dehydratase, 1w31, r1w31sf.
Identifiers
Local EPrints ID: 24094
URI: http://eprints.soton.ac.uk/id/eprint/24094
ISSN: 0907-4449
PURE UUID: 72afa51e-3314-46a3-a849-6eb80f9cc4e4
Catalogue record
Date deposited: 22 Mar 2006
Last modified: 15 Mar 2024 06:52
Export record
Altmetrics
Contributors
Author:
P.T. Erskine
Author:
L. Coates
Author:
R. Newbold
Author:
A.A. Brindley
Author:
F. Stauffer
Author:
G.D.E Beaven
Author:
R. Gill
Author:
A. Coker
Author:
S.P. Wood
Author:
M.J. Warren
Author:
R. Neier
Author:
J.B. Cooper
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics